High prevalence of unique recombinant forms of HIV-1 in Ghana: Molecular epidemiology from an antiretroviral resistance study

Journal of Acquired Immune Deficiency Syndromes

Volumn 48, Issue 5, 2008, Pages 599-606

  Delgado, Elena ^a   Ampofo, William Kwabena ^b   Sierra, María ^a   Torpey, Kwasi ^c   Pérez Álvarez, Lucía ^a   Bonney, Evelyn Yayra ^b   Mukadi, Ya Diul ^d   Lartey, Margaret ^b   Nyarko, Charles ^e   Amenyah, Richard Noamesi ^c   Thomson, Michael M ^a   Nájera, Rafael ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b UNIVERSITY OF GHANA   (Ghana)

^c Public Health Division   (Ghana)

^d FAMILY HEALTH INTERNATIONAL   (United States)

^e St Martin's des Porres Hospital   (Ghana)

Author keywords

Antiretroviral resistance; Ghana; HIV 1; Recombinant; Subtype

Indexed keywords

RNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEINASE INHIBITOR;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; EUKARYOTE EVOLUTION; GHANA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOLECULAR EPIDEMIOLOGY; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS RESISTANCE; VIRUS STRAIN; ANTIVIRAL RESISTANCE; CLASSIFICATION; DRUG EFFECT; EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC RECOMBINATION; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; MUTATION; PREVALENCE; STRUCTURAL GENE; VIROLOGY;

ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; EPIDEMIOLOGY, MOLECULAR; GENES, POL; GHANA; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; POLYMORPHISM, GENETIC; PREVALENCE; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 50949104038     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181806c0e     Document Type: Article

References (41)

1. Gao F, Bailes E, Robertson DL, et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature. 1999;397:436-441.
2. Los Alamos HIV Database. Available at: http://hiv-web.lanl.gov/content/ index. Accessed February 28, 2008.
3. Hamel DJ, Donald J, Sankale JL, et al. Twenty years of prospective molecular epidemiology in Senegal: changes in HIV diversity. AIDS Res Hum Retroviruses. 2007;23:1189-1196.
4. Tebit DM, Ganame J, Sathiandee K, et al. Diversity of HIV in rural Burkina Faso. J Acquir Immune Defic Syndr. 2006;43:144-152.
5. Vidal N, Koyalta D, Richard V, et al. High genetic diversity of HIV-1 strains in Chad, West Central Africa. J Acquir Immune Defic Syndr. 2003; 33:239-246.
6. Mamadou S, Montavon C, Ben A, et al. Predominance of CRF02-AG and CRF06-cpx in Niger, West Africa. AIDS Res Hum Retroviruses. 2002;18: 723-726.
7. Konings FA, Haman GR, Xue Y, et al. Genetic analysis of HIV-1 strains in rural eastern Cameroon indicates the evolution of second-generation recombinants to circulating recombinant forms. J Acquir Immune Defic Syndr. 2006;42:331-341.
8. Toni T, Adje-Toure C, Vidal N, et al. Presence of CRF09-cpx and complex CRF02-AG/CRF09-cpx recombinant HIV type 1 strains in Cote d'Ivoire, West Africa. AIDS Res Hum Retroviruses. 2005;21: 667-672.
9. Meloni ST, Sankalé JL, Hamel DJ, et al. Molecular epidemiology of human immunodeficiency virus type 1 sub-subtype A3 in Senegal from 1988 to 2001. J Virol. 2004;78:12455-12461.
10. Nájera R, Delgado E, Pérez-Alvarez L, et al. Genetic recombination and its role in the development of the HIV-1 pandemic. AIDS. 2002;16(Suppl 4): S3-S16.
11. Thomson MM, Nájera R. Molecular epidemiology of HIV-1 variants in the global AIDS pandemic: an update. AIDS Rev. 2005;7:210-224.
12. UNAIDS, 2006 Report of the Global AIDS Epidemic. Available at: http:// www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport. Accessed February 28, 2008.
13. Hemelaar J, Gouws E, Ghys PD, et al. Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004. AIDS. 2006;20: W13-W23.
14. Fischetti L, Opare-Sem O, Candotti D, et al. Molecular epidemiology of HIV in Ghana: dominance of CRF02-AG. J Med Virol. 2004;73: 158-166.
15. WHO. "Ghana: Summary Country Profile: HIV/AIDS Treatment Scale-Up", June 2005. Available at: http://www.who.int/hiv/HIVCP-GHA.pdf. Accessed February 28, 2008.
16. World Bank Portfolio for Ghana, as of August 2005. http://www-wds. worldbank.org. Accessed February 28, 2008.
17. Kinomoto M, Appiah-Opong R, Brandful JA, et al. HIV-1 proteases from drug-naive West African patients are differentially less susceptible to protease inhibitors. Clin Infect Dis. 2005;41:243-251.
18. Brandful JAM, Coetzer ME, Cillers T, et al. Phenotypic characterization of HIV type 1 isolates from Ghana. AIDS Res Hum Retroviruses. 2007;23: 144-152.
19. Brandful JA, Ampofo WK, Janssens W, et al. Genetic and phylogenetic analysis of HIV type 1 strains from southern Ghana. AIDS Res Hum Retroviruses. 1998;14:815-819.
20. Sagoe KWC, Dwidar M, Lartey M, et al. Variability of the human immunodeficiency virus type 1 polymerase gene from treatment näive patients in Accra, Ghana. J Clin Virol. 2007;40:163-167. Epub September 10, 2007.
21. Villahermosa ML, Thomson M, Vazquez de Parga E, et al. Improved conditions for extraction and amplification of human immunodeficiency virus type 1 RNA from plasma samples with low viral load. J Hum Virol. 2000;3:27-34.
22. Kumar S, Tamura K, Nei M. MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform. 2004;5:150-163.
23. Lole KS, Bollinger RC, Paranjape RS, et al. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol. 1999;73:152-160 (Available at: http://sray.med.som.jhmi.edu/ SCRoftware/simplot/).
24. Rhee SY, Gonzales MJ, Kantor R, et al. Human immunodeficiency virus reverse transcriptase and protease sequence database. Nucl Acids Res. 2003;31:298-303.
25. Baxter JD, Schapiro JM, Boucher CA, et al. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol. 2006;80:10794-10801.
26. Mamadou S, Vidal N, Montavon C, et al. Emergence of complex and diverse CRF02-AG/CRF06-cpx recombinant HIV type 1 strains in Niger, West Africa. AIDS Res Hum Retroviruses. 2003;19:77-82.
27. Powell RL, Zhao J, Konings FA, et al. Circulating recombinant form (CRF) 37-cpx: an old strain in Cameroon composed of diverse, genetically distant lineages of subtypes A and G. 1. AIDS Res Hum Retroviruses. 2007;23:923-933.
28. Magiorkinis G, Paraskevis D, Vandamme AM, et al. In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity. J Gen Virol. 2003;84:2715-2722.
29. Thomson MM, Sierra M, Tanuri A, et al. Analysis of near full-length genome sequences of HIV type 1 BF intersubtype recombinant viruses from Brazil reveals their independent origins and their lack of relationship to CRF12-BF. AIDS Res Hum Retroviruses. 2004;20:1126-1133.
30. McCutchan, et al. HIV-1 type 1 circulating recombinant form CRF09-cpx from West Africa combines subtypes A. F, G and may share ancestors with CRF02-AG and Z321. AIDS Res Hum Retroviruses. 2004;20:819-826.
31. Konings FA, Burda ST, Urbanski MM, et al. Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form 02-AG (CRF02-AG) has a higher in vitro replicative capacity than its parental subtypes A and G. J Med Virol. 2006;78:523-534.
32. Njai HF, Gali Y, Vanham G, et al. The predominance of human immunodeficiency virus type I (HIV-1) circulating recombinant form 02 (CRF02-AG) in West Central Africa may be related to its replicative fitness. Retrovirology. 2006;3:40.
33. Fischetti L, Opare-Sem O, Candotti D, et al. Higher viral load may explain the dominance of CRF02-AG in the molecular epidemiology of HIV in Ghana. AIDS. 2004;18:1208-1210.
34. Coté AM, Sobela F, Dzokoto A, et al. Transactional sex is the driving force in the dynamics of HIV in Accra, Ghana. AIDS. 2004;18: 917-925.
35. Delgado E, Ampofo W, Torpey K, et al. Characterisation of Near Full-Length Genomes of Subsubtype A3 and A3/CRF02-AG Recombinant Forms in Ghana. Abstract WEPE0017. XVI International AIDS Conference, Toronto, Canada, August 13-18, 2006. International AIDS Society. Geneva, Switzerland.
36. Kim EY, Winters MA, Kagan RM, et al. Functional correlates of insertion mutations in the protease gene of human immunodeficiency virus type 1 isolates from patients. J Virol. 2001;75:11227-11233.
37. Derache A, Traore O, Koita V, et al. Genetic diversity and drug resistance mutations in HIV type 1 from untreated patients in Bamako, Mali. Antivir Ther. 2007;12:123-129.
38. Kassu A, Fujino M, Matsuda M, et al. Molecular epidemiology of HIV type 1 in treatment-naive patients in north Ethiopia. AIDS Res Hum Retroviruses. 2007;23:564-568.
39. Holguín A, Paxinos E, Hertogs K, et al. Impact of frequent natural polymorphisms at the protease gene on the in vitro susceptibility to protease inhibitors in HIV-1 non-B subtypes. J Clin Virol. 2004;31: 215-220.
40. Thomson MM, Pérez-Á lvarez L, Nájera R. Molecular epidemiology of HIV-1 genetic forms and its significance for vaccine development and therapy. Lancet Infect Dis. 2002;2:461-471.
41. Nora T, Charpentier C, Tenaillon O, et al. Contribution of recombination to the evolution of human immunodeficiency viruses expressing resistance to antiretroviral treatment. J Virol. 2007;81:7620-7628. Epub May 9, 2007.