The competition of charge remote and charge directed fragmentation mechanisms in quaternary ammonium salt derivatized peptides - An isotopic exchange study

Journal of the American Society for Mass Spectrometry

Volumn 22, Issue 12, 2011, Pages 2103-2107

  Cydzik, Marzena ^a   Rudowska, Magdalena ^a   Stefanowicz, Piotr ^a   Szewczuk, Zbigniew ^a  

^a UNIVERSITY OF WROC AW   (Poland)

Author keywords

Derivatization of peptides; Peptide sequencing; Quaternary ammonium salts

Indexed keywords

COMPETING MECHANISMS; DERIVATIZATIONS; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; FRAGMENTATION MECHANISM; ISOTOPIC EXCHANGE; ISOTOPIC LABELING; MOBILE PROTONS; PEPTIDE BONDS; PEPTIDE SEQUENCING; QUATERNARY AMMONIUM SALT; QUATERNARY SALTS; SENSITIVE DETECTION;

AMIDES; DEUTERIUM; ELECTROSPRAY IONIZATION; MASS SPECTROMETRY; PEPTIDES; PROTONS; SALTS;

AMMONIUM COMPOUNDS;

ARTICLE; BINDING COMPETITION; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; DERIVATIZATION; FRAGMENTATION REACTION; ISOTOPE LABELING; PEPTIDE ANALYSIS; PROTEIN QUATERNARY STRUCTURE; PROTON TRANSPORT; REACTION ANALYSIS; STRUCTURE ANALYSIS; SURFACE CHARGE;

DEUTERIUM EXCHANGE MEASUREMENT; IONS; MODELS, MOLECULAR; PEPTIDES; QUATERNARY AMMONIUM COMPOUNDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84856183169     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0245-2     Document Type: Article

References (15)

1. Hunt, D. F., Yates, J. R., Shabanowitz, J., Winston, S., Hauer, C. R.: Protein sequencing by tandem mass spectrometry. Proc. Natl. Acad. Sci. U. S. A. 83, 6233-6237(1986) (Pubitemid 17174712)
2. Tsaprailis, G., Nair, H., Somogyi, A., Wysocki, V. H., Zhong, W., Futrell, J. H., Summerfield, S. G., Gaskell, S. J.: Influence of secondary structure on the fragmentation of protonated peptides. J. Am. Chem. Soc. 121, 5142-5154(1999) (Pubitemid 29275721)
3. Paizs, B., Suhai, S.: Fragmentation pathways of protonated peptides. Mass Spectrom. Rev. 24, 508-548(2005)
4. Dongre, A. R., Jones, J. L., Somogyi, A., Wysocki, V. H.: Influence of peptide composition, gas-phase basicity, and chemical modification on fragmentation efficiency: Evidence for the mobile proton model. J. Am. Chem. Soc. 118, 8365-8374(1996) (Pubitemid 26305258)
5. McCormack, A. L., Somogyi, A., Dongre, A. R., Wysocki, V. H.: Fragmentation of protonated peptides: Surface-induced dissociation in conjunction with a quantum mechanical approach. Anal. Chem. 65, 2859-2872(1993)
6. Tomer, K. B., Crow, F. W., Gross, M. L.: Location of double bond position in unsaturated fatty acids by negative ion MS/MS. J. Am. Chem. Soc. 105, 5487-5488(1983)
7. Cheng, C., Gross, M. L.: Applications and mechanisms of charge-remote fragmentation. Mass Spectrom. Rev. 19, 398-420(2000)
8. Adams, J.: Charge-remote fragmentations: Analytical applications and fundamental studies. Mass Spectrom. Rev. 9, 141-186(1990)
9. Syrstad, E. A., Turecek, F.: Toward a general mechanism of electron capture dissociation. J. Am. Soc. Mass Spectrom. 16, 208-224(2005) (Pubitemid 40203144)
10. Zaia, J., Biemann, K.: Comparison of charged derivatives for high energy collision-induced dissociation tandem mass spectrometry. J. Am. Soc. Mass Spectrom. 6, 428-436(1995)
11. Liao, P. C., Huang, Z. H., Allison, J.: Charge remote fragmentation of peptides following attachment of a fixed positive charge: A matrixassisted laser desorption/ionization post-source decay study. J. Am. Soc. Mass Spectrom. 8, 501-509(1997) (Pubitemid 27176183)
12. Sadagopan, N., Watson, J. T.: Mass spectrometric evidence for mechanism of fragmentation of charge-derivatized peptides. J. Am. Soc. Mass. Spectrom. 12, 399-409(2001) (Pubitemid 34546610)
13. Reid, G. E., Simpson, R. J.: Leaving group and gas phase neighboring group effects in the side chain losses from protonated serine and its derivatives. J. Am. Soc. Mass Spectrom. 11, 1047-1060(2000) (Pubitemid 34563211)
14. Cydzik, M., Rudowska, M., Stefanowicz, P., Szewczuk, Z.: Derivatization of peptides as quaternary ammonium salts for sensitive detection by ESI-MS. J. Pept. Sci. 17, 445-453(2011)
15. Laskin, J., Lifshitz, C.: Principles of Mass Spectrometry Applied to Biomolecules. Wiley, New Jersey (2006)