Topical timolol for infantile hemangiomas: Putting a note of caution in "cautiously optimistic"

Pediatric Dermatology

Volumn 29, Issue 1, 2012, Pages 127-130

  McMahon, Patrick ^a   Oza, Vikash ^a   Frieden, Ilona J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROPRANOLOL; TIMOLOL MALEATE;

ALOPECIA; ANGIONEUROTIC EDEMA; APNEA; ASTHMA; BEHAVIOR DISORDER; BLEPHARITIS; BRADYCARDIA; BRAIN ISCHEMIA; BRONCHOSPASM; CAPILLARY HEMANGIOMA; CEREBROVASCULAR ACCIDENT; CONFUSION; CONJUNCTIVITIS; COUGHING; CYANOSIS; DIARRHEA; DISSOCIATED BEHAVIOR; DIZZINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG POTENCY; EYE DISCOMFORT; FATIGUE; HEART ARREST; HEART ARRHYTHMIA; HEART BLOCK; HEART FAILURE; HUMAN; HYPEREMIA; HYPERTENSION; HYPOGLYCEMIA; HYPOTENSION; INSOMNIA; NAUSEA; NIGHTMARE; NONHUMAN; NOTE; PRIORITY JOURNAL; PRURITUS; PSORIASIS; RASH; RESPIRATORY FAILURE; SLEEP DISORDER; SYNCOPE; URTICARIA;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; HEMANGIOMA; HUMANS; INFANT; PATIENT SELECTION; SKIN NEOPLASMS; TIMOLOL;

EID: 84856170551     PISSN: 07368046     EISSN: 15251470     Source Type: Journal    
DOI: 10.1111/j.1525-1470.2011.01685.x     Document Type: Note

References (21)

1. Guo S, Ni N,. Topical treatment for capillary hemangioma of the eyelid using β-blocker solution. Arch Ophthalmol 2010; 128: 255-256.
2. Ni N, Langer P, Wagner R, et al., Topical timolol for periocular hemangioma: report of further study. Arch Ophthalmol 2011; 129: 377-379.
3. Pope E, Chakkittakandiyil A,. Topical timolol gel for infantile hemangiomas: a pilot study. Arch Dermatol 2010; 146: 564-565.
4. Khunger N, Pahwa M,. Dramatic response to topical timolol lotion of a large hemifacial infantile haemangioma associated with PHACE syndrome. Br J Dermatol 2011; 164: 886-888.
5. Chakkittakandiyil A, Phillips R, Frieden IJ, et al., Timolol maleate 0.5% gel forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study. Pediatr Dermatol 2011; 29: 28-31.
6. Coppens G, Stalmans I, Zeyen T, et al., The safety and efficacy of glaucoma medication in the pediatric population. J Pediatr Ophthalmol Strabismus 2009; 46: 12-18.
7. Shedden AH, Laurence J, Barrish A, et al., Plasma timolol concentrations of timolol maleate: timolol gel-forming solution (TIMOPTIC-XE) once daily versus timolol maleate ophthalmic solution twice daily. Doc Ophthalmol 2001; 103: 73-79. (Pubitemid 32926916)
8. Vlasses PH, Ribeiro LG, Rotmensch HH, et al., Initial evaluation of transdermal timolol: serum concentrations and beta-blockade. J Cardiovasc Pharmacol 1985; 7: 245-250. (Pubitemid 15083818)
9. Hao J, Yang MB, Liu H, et al., Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration. J Ocul Pharmacol Ther 2011; 27: 453-459.
10. Korte JM, Kaila T, Saari KM,. Systemic bioavailability and cardiopulmonary effects of 0.5% timolol eye drops. Graefes Arch Clin Exp Ophthalmol 2002; 240: 430-435. (Pubitemid 36097063)
11. Lohmöller G, Frohlich ED,. A comparison of timolol and propranolol in essential hypertension. Am Heart J 1975; 89: 437-442.
12. Achong MR, Piafsky KM, Ogilvie RI,. Duration of cardiac effects of timolol and propranolol. Clin Pharmacol Ther 1976; 19: 148-152.
13. Olson RJ, Bromberg BB, Zimmerman TJ,. Apneic spells associated with timolol therapy in a neonate. Am J Ophthalmol 1979; 88: 120-122. (Pubitemid 9187781)
14. Bailey PL,. Timolol and postoperative apnea in neonates and young infants. Anesthesiology 1984; 61: 622.
15. Zimmerman TJ, Kooner KS, Morgan KS,. Safety and efficacy of timolol in pediatric glaucoma. Surv Ophthalmol 1983; 28 (Suppl): 262-264.
16. McMahon CD, Hetherington J Jr, Hoskins HD Jr, et al., Timolol and pediatric glaucomas. Ophthalmology 1981; 88: 249-252. (Pubitemid 11155522)
17. Boger WP 3rd, Walton DS,. Timolol in uncontrolled childhood glaucomas. Ophthalmology 1981; 88: 253-258. (Pubitemid 11155523)
18. de Graaf M, M P J Breur J, RaphaÃl MF, et al., Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants. J Am Acad Dermatol 2011; 65: 320-327.
19. Blatt J, Morrell DS, Buck S, et al., {beta}-Blockers for infantile hemangiomas: a single-institution experience. Clin Pediatr (Phila) 2011; 50: 757-763.
20. Holland KE, Frieden IJ, Frommelt PC, et al., Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol 2010; 146: 775-778.
21. Nelson WL, et al., Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985. Am J Ophthlmol 1987; 104: 97-98.