Plasma timolol concentrations of timolol maleate: Timolol gel-forming solution (TIMOPTIC-XE®) once daily versus timolol maleate ophthalmic solution twice daily

Documenta Ophthalmologica

Volumn 103, Issue 1, 2001, Pages 73-79

  Shedden, Arthur H ^a,b   Laurence, Jean ^a   Barrish, Andrea ^a   Olah, Timothy V ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Shedden and Associates LLC   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Gel; Gellan gum; Plasma levels; Timolol

Indexed keywords

TIMOLOL MALEATE;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG FORMULATION; GEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OBSERVATION; QUANTITATIVE ASSAY; RANDOMIZED CONTROLLED TRIAL; SOLUTION AND SOLUBILITY;

ABSORPTION; ADRENERGIC BETA-ANTAGONISTS; ADULT; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG DELIVERY SYSTEMS; GELS; HUMANS; MALE; OPHTHALMIC SOLUTIONS; TIMOLOL;

EID: 0034815175     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017962731813     Document Type: Article

References (7)

1. Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit
2. Timolol maleate in gel-forming solution: A novel formulation of timolol maleate
3. A double-masked, placebo-controlled evaluation of timolol in gel vehicle
4. The ocular hypotensive effect of once daily administration of timolol-in-Gelrite (TG) vs. timolol solution (TS)
5. Absorption of ocular timolol
6. Plasma timolol in glaucoma patients
7. Improving the therapeutic index of topically applied ocular drugs