Spontaneous staphylococcal cassette chromosome mec element excision in Staphylococcus aureus nasal carriers

Journal of Clinical Microbiology

Volumn 50, Issue 2, 2012, Pages 469-471

  Boundy, Sam ^a   Zhao, Qixun ^a   Fairbanks, Carly ^a   Folgosa, Lauren ^a   Climo, Michael ^a,b   Archer, Gordon L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAPHYLOCOCCUS PROTEIN A;

ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIUM CARRIER; BACTERIUM ISOLATE; CLINICAL ARTICLE; CONTROLLED STUDY; GENETIC VARIABILITY; GENOME SIZE; GENOMIC ISLAND; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MICROFLORA; MULTILOCUS SEQUENCE TYPING; NONHUMAN; NOSE; PILOT STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PULSED FIELD GEL ELECTROPHORESIS; STAPHYLOCOCCAL CASSETTE CHROMOSOME MEC; STAPHYLOCOCCUS AUREUS;

CARRIER STATE; CHROMOSOMES, BACTERIAL; CLUSTER ANALYSIS; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE DELETION; GENOTYPE; HUMANS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR TYPING; NASAL MUCOSA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 84856157340     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01063-11     Document Type: Article

References (14)

1. Crossley KB, Jefferson KK, Archer GL, Fowler VG, Jr (ed). 2009. Staphylococci in human disease, 2nd ed. Wiley-Blackwell, West Sussex, United Kingdom.
2. Diep BA, et al. 2008. The arginine catabolic mobile element and Staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J. Infect. Dis. 197:1523-1530. (Pubitemid 351706482)
3. Ender M, McCallum N, Adhikari R, Berger-Bachi B. 2004. Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus. Antimicrob. Agents Chemother. 48:2295-2297. (Pubitemid 38691635)
4. Fey PD, Climo MW, Archer GL. 1998. Determination of the chromosomal relationship between mecA and gyrA in methicillin-resistant coagulase-negative staphylococci. Antimicrob. Agents Chemother. 42: 306-312. (Pubitemid 28114436)
5. Fey PD, et al. 2003. Comparative molecular analysis of community- or hospital-acquired methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 47:196-203. (Pubitemid 36070364)
6. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC). 2009. Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob. Agents Chemother. 53: 4961-4967.
7. Ito T, et al. 2001. Structural comparison of three types of Staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 45:1323-1336. (Pubitemid 32374098)
8. Ito T, et al. 2004. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob. Agents Chemother. 48:2637-2651. (Pubitemid 38823437)
9. Jain R, et al. 2011. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N. Engl. J. Med. 364:1419-1430.
10. Liu C, et al. 2008. A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. Clin. Infect. Dis. 46:1637-1646. (Pubitemid 351706759)
11. Noto MJ, Fox PM, Archer GL. 2008. Spontaneous deletion of the methicillin resistance determinant, mecA, partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 52:1221-1229. (Pubitemid 351521980)
12. Orscheln RC, Hunstad DA, Fritz SA, et al. 2009. Contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections. Clin. Infect. Dis. 49:536-542.
13. Shopsin B, et al. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J. Clin. Microbiol. 37:3556-3563. (Pubitemid 29491091)
14. Wang L, Archer GL. 2010. Roles of CcrA and CcrB in excision and integration of staphylococcal cassette chromosome mec, a Staphylococcus aureus genomic island. J. Bacteriol. 192:3204-3212.