Quantification of airway deposition of intact and fragmented pollens

International Journal of Environmental Health Research

Volumn 21, Issue 6, 2011, Pages 427-440

  Horváth, Alpár ^a   Balásházy, Imre ^b,c   Farkas, Árpád ^b   Sárkány, Zoltán ^d   Hofmann, Werner ^e   Czitrovszky, Aladár ^f   Dobos, Erik ^g  

^a GLAXOSMITHKLINE   (United Kingdom)

^b KFKI ATOMIC ENERGY RESEARCH INSTITUTE   (Hungary)

^c Respirisk Scientific Research Ltd   (Hungary)

^d UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^e UNIVERSITY OF SALZBURG   (Austria)

^f WIGNER RESEARCH CENTRE FOR PHYSICS   (Hungary)

^g UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Airway deposition of pollens; Asthma modelling; Monte Carlo simulations

Indexed keywords

ALLERGY; ASTHMA; ATMOSPHERIC DEPOSITION; COMPUTER SIMULATION; FRAGMENTATION; MONTE CARLO ANALYSIS; NUMERICAL MODEL; POLLEN; THUNDERSTORM;

AIRWAY DYNAMICS; ARTICLE; ASTHMA; COMPUTER SIMULATION; DISEASE EXACERBATION; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PARTICLE SIZE; POLLEN; SEASONAL VARIATION;

AIR POLLUTANTS; ASTHMA; COMPUTER SIMULATION; HUMANS; INHALATION EXPOSURE; LUNG; MONTE CARLO METHOD; PARTICLE SIZE; POLLEN; RAIN; RISK FACTORS; STOCHASTIC PROCESSES;

EID: 84856147846     PISSN: 09603123     EISSN: 13691619     Source Type: Journal    
DOI: 10.1080/09603123.2011.574269     Document Type: Article

References (56)

1. Asgharian B, Menache MG, Miller FJ. 2004. Modeling age-related particle deposition in humans. J Aerosol Med. 17(3):213-224. (Pubitemid 39299322)
2. Balásházy I, Hofmann W, Farkas Á. 2008. Three-dimensional model for aerosol transport and deposition in expanding and contracting alveoli. Inhal Toxicol. 20(6):1-11.
3. Balásházy I, Hofmann W, Heistracher T. 2003. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol. 94(5):1719-1725. (Pubitemid 36457417)
4. Bauman A. 1996. Asthma associated with thunderstorm. BMJ. 312:590-591.
5. Beigelman-Aubry C, Capderou A, Grenier PA, Straus C, Becquemin MH, Similowski T, Zelter M. 2002. Mild intermittent asthma: CT assessment of bronchial cross-sectional area and lung attenuation at controlled lung volume. Radiology 223:181-187. (Pubitemid 34258207)
6. Björkstén B, Clayton T, Ellwood P, Stewart A, Strachan D. 2008. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immu. 19(2):110-124. (Pubitemid 351197288)
7. Cassee FR, Freijer JI, Subramaniam R, Asgharian B, Miller JF, van Bree L, Rombout PJA. 1999. Development of a model for human and rat airway particle deposition: Implications for risk assessment.. National Institute of Public Health and Environment, Bilthoven, The Netherlands. 34 pp. Report No. 624029001. Available from the website: http://rivm.openrepository.com/rivm/bitstream/ 10029/10229/1/650010018.pdf
8. Cecchi L, Malaspina TT, Albertini R, Zanca M, Ridolo M, Usberti I, Morabito M, Dall'Aglio P, Orlandini S. 2007. The contribution of long-distance transport to the presence of Ambrosia pollen in central northern Italy. Aerobiologia. 23(2):145-151. (Pubitemid 47300263)
9. Celenza A, Fathergill J, Kupek R, Shaw RJ. 1996. Thunderstorm associated asthma: A detailed analysis of environmental factors. BMJ. 312:604-607. (Pubitemid 26079595)
10. Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. 2004. Ultrafine particle deposition in subjects with asthma. Environ Health Persp. 112(8):879-882. (Pubitemid 38811931)
11. D'Amato G, Spiekshma FT, Liccardi G, Jäger S, Russo M, Kontou-Fill K, Nikkels H, Wüthrich B, Bonini S. 1998. Pollen-related allergy in Europe. Allergy. 53(6):567-578. (Pubitemid 28307924)
12. Darquenne C, Paiva M. 1996. Two-and three-dimensional simulations of aerosol transport and deposition in alveolar zone of human lung. J Appl Physiol. 80(4):1401-1414. (Pubitemid 26118548)
13. Driessen MN, Quanjer PH. 1991. Pollen deposition in intrathoracic airways. Eur Respir J. 4(3):359-363.
14. Farkas Á, Balásházy I, Szocs K. 2006. Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. J Aerosol Med. 19(3):329-343. (Pubitemid 44739780)
15. Farkas Á, Balásházy I. 2007. Simulation of the effect of local obstructions and blockage on airflow and aerosol deposition in central human airways. J Aerosol Sci. 38(8):865-884. (Pubitemid 47268461)
16. Farkas Á, Balásházy I. 2008. Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Comput Biol Med. 38(4):508-518.
17. Feliziani V. 1986. Pollini di interesse allergologico: Guida al loro riconoscimento. Milano: Elsevier. 212 pp.
18. Frey U, Suki B. 2008. Complexity of chronic asthma and chronic obstructive pulmonary disease: Implications for risk assessment, and disease progression and control. Lancet. 372(9643):1088-1089.
19. Guerico JP, Birch S, Fernandez RJ, Sackner MA. 1980. Deposition of ragweed pollen and extract on nasal mucosa of patients with allergic rhinitis: Effect on nasal airflow resistance and nasal mucus velocity. J Allergy Clin Immun. 66(1):61-69. (Pubitemid 10056830)
20. Haefeli-Bleuer B, Weibel ER. 1988. Morphometry of the human pulmonary acinus. Anat Rec. 220(4):401-414.
21. Heyder J, Gebhart J, Rudolph G, Schiller CF, Stahlhofen W. 1986. Deposition of particles in the human respiratory tract in the size range for 0.005 to 15 mm. J Aerosol Sci. 17(5):811-825. (Pubitemid 17492310)
22. Hofmann W, Koblinger L. 1992. Monte Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their sensitivity to parameter variations. J Aerosol Sci. 21(5):675-688.
23. International Commission on Radiological Protection (ICRP). 1994. Human respiratory tract model for radiological protection. ICRP Publication 66. Annals of the ICRP 24. Oxford: Pergamon Press.
24. Joly C, Barillé L, Barreau M, Mancheron A, Visset L. 2007. Grain and annulus diameter as criteria for distinguishing pollen grains of cereals from wild grasses. Rev Palaeobot Palyno. 146:221-233. (Pubitemid 47334741)
25. Kaminsky DA, Irvin CG, Lundblad LK, Thompson-Figueroa J, Klein J, Sullivan MJ, Flynn F, Lang S, Bourassa L, Burns S, Bates JH. 2008. Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine. J Appl Physiol. 104(1):10-19.
26. Kang DY, Son MS, Eum CH, Kim WS, Lee S. 2007. Size determination of pollens using gravitational and sedimentation field-flow fractionation. Bull Korean Chem Soc. 28(4):613-618. (Pubitemid 46683268)
27. Kimbell JS, Segal RA, Asgharian B, Wong BA, Schroeter JD, Southall JP, Dickens CJ, Brace G, Miller FJ. 2007. Characterisation of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages. J Aerosol Med. 20(1):59-74. (Pubitemid 46542937)
28. Kleinstreuer C, Zhang Z, Li Z. 2008. Modeling airflow and particle transport/deposition in pulmonary airways. Resp Physiol Neurobi. 163(1-3):128-138.
29. Koblinger L, Hofmann W. 1985. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys Med Biol. 30(6):541-556. (Pubitemid 15041527)
30. Koblinger L, Hofmann W. 1990. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. J Aerosol Sci. 21(5):661-674.
31. Kraft M. 1999. The distal airways: Are they important in asthma? Eur Respir J. 14(6):1403-1417. (Pubitemid 30019540)
32. Lewis RD, Sterling DA, King B, Hendershott L, Goodgold H, Hutcheson P. 1999. Evidence of large particle allergen inhalation from direct contact with surfaces. Ann Allerg Asthma Im. 83(1):41-48. (Pubitemid 30336810)
33. Longest PW, Vinchurkar S, Martonen T. 2006. Transport and deposition of respiratory aerosols in models of childhood asthma. J Aerosol Sci. 37(10):1234-1257. (Pubitemid 44468215)
34. Lutchen KR, Jensen A, Atileh H, Kaczka DW, Israel E, Suki B, Ingenito EP. 2001. Airway constriction pattern is a central component of asthma severity. Am J Respir Crit Care Med. 164(2):207-215. (Pubitemid 34001283)
35. Martonen T, O'Rourke M. 2002a. Disposition of mulberry pollen in the human respiratory systems: A mathematical model. EPA/600/J-94/065. Washington, DC: US Environmental Protection Agency.
36. Martonen T, O'Rourke M. 2002b. Deposition patterns of ragweed pollen in the human respiratory tract. EPA/600/J-92/312. Washington, DC: US Environmental Protection Agency.
37. Martonen TB, Fleming J, Schroeter J, Conway J, Hwang D. 2003. In silico modelling of asthma. Adv Drug Deliv Rev. 55(7):829-849.
38. Michel FB, Marty JP, Quet L, Cour P. 1977. Penetration of inhaled pollen into the respiratory tract. Am Rev Resp Dis. 115(4):609-616. (Pubitemid 8074574)
39. Murray V, Venables K, Laing-Morton T, Partridge M, Thurston MPJ, Williams D. 1994. Epidemic of asthma possibly related to thunderstorms. BMJ. 309:131-132. (Pubitemid 24216466)
40. Newson R, Strachan D, Archibald E, Emberlin J, Hardaker P, Collier C. 1997. Effect of thunderstorm and airborn grass pollen on the incidence of acute asthma in England, 1990-1994. Thorax. 52(8):680-685. (Pubitemid 27404980)
41. O'Leary M, Koolpiruck D, Balachandran W, Emberlin J, Lewis R. 2005. The role of electrostatic charge accumulated by respirable sized allergens with regard to thunderstorm asthma. Industry Applications Conference, 2005. 40th IAS Annual Meeting. Conference Record 2:778-783. (ISBN: 0-7803-9208-6). (Pubitemid 44042536)
42. Pearce N, Douwes J, Beasley R. 2000. The rise and rise of asthma: A new paradigm for the new millennium? J Epidemiol Biostat. 5(1):5-16.
43. Raabe OG, Yeh HC, Schum GM, Phalen RF. 1980. Tracheobronchial geometry: Human dog, rat and hamster.. Lovelace Foundation report LF-53. Available from the website: http://mae.ucdavis.edu/wexler/lungs/LF53-Raabe/text.pdf
44. Rantio-Lehtimaki A, Kauppinen E, Koivikko A. 1987. Efficiency of a new bioaerosol sampler in sampling Betula pollen for antigen analyses. Exp Suppl. 51:382-390.
45. Samee S, Altes T, Powers P, de Lange EE, Knight-Scott J, Rakes G, Mugler JP 3rd, Ciambotti JM, Alford BA, Brookeman JR, et al. 2003. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: Assessment of response to methacholine and exercise challenge. J Allergy Clin Immunol. 111(6):1201-1202.
46. Schiller CF, Gebhart J, Heyder J, Rudolf G, Stahlhofen W. 1988. Deposition of monodisperse insoluble aerosol particles in the 0.005 to 0.2 mm size range within the human respiratory tract. Ann of Occup Hyg. 32(VI):41-49.
47. Soler M, Le Bouffant L, Charpin J. 1982. Retention of pollen grains in human lung. Allergy. 37(5):373-376.
48. Stahlhofen W, Rudolf G, James AC. 1989. Intercomparison of experimental regional aerosol deposition data. J Aerosol Med. 2(3):285-308.
49. Taylor PE, Flagon RC, Valenta R, Glovsky MM. 2002. Release of allergens as respirable aerosols: A link between grass pollen and asthma. J Allergy Clin Immun. 109(1):51-56. (Pubitemid 34112129)
50. Tgavalekos NT, Tawhai M, Harris RS, Musch G, Vidal-Melo M, Venegas JG, Lutchen KR. 2005. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: An image functional modeling approach. J Appl Physiol. 99(6):2388-2397. (Pubitemid 41691662)
51. van Hout R, Katz J. 2004. A method for measuring the density of irregularly shaped biological aerosols such as pollen. J Aerosol Sci. 35(11):1369-1384. (Pubitemid 39457750)
52. Venegas JG, Winkler T, Musch G, Vidal-Melo M, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani J, Harris RS. 2005. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature. 434:777-782. (Pubitemid 44739522)
53. Wilson AF, Novey HS, Berke RA, Surprenant EL. 1973. Deposition of inhaled pollen and pollen extract in human airways. New Engl J Med. 288:1056-1058.
54. Yeh HC, Schum GM. 1980. Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol. 42(3):461-480. (Pubitemid 10092310)
55. Yu CP, Diu CK, Soong TT. 1981. Statistical analysis of aerosol deposition in nose and mouth. Am Ind Hyg Assoc J. 42(10):726-733. (Pubitemid 11014781)
56. Zhang Z, Kleinstreuer C, Donohue JF, Kim CS. 2005. Comparison of micro-and nano-size particle depositions in a human upper airway model. J Aerosol Sci. 36(2):211-233. (Pubitemid 40138840)