Combined hypertriglyceridemic and insulin-glucose clamps for the characterization of substrate oxidation and plasma elimination of a long-chain triglyceride emulsion in healthy men

Metabolism: Clinical and Experimental

Volumn 61, Issue 2, 2012, Pages 221-228

  Åberg, Viveca ^a   Thörne, Anders ^a,b   Alvestrand, Anders ^a,c   Nordenström, Jörgen ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Sodertalje Hospital   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADRENALIN; FATTY ACID; GLUCOSE; INSULIN; LACTIC ACID; LIPID EMULSION; LONG CHAIN TRIACYLGLYCEROL; NORADRENALIN;

ADULT; ARTICLE; CALORIMETRY; ENERGY EXPENDITURE; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN EXPERIMENT; HYPERTRIGLYCERIDEMIC CLAMP TECHNIQUE; LIPID OXIDATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROCEDURES; RESPIRATORY QUOTIENT; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; BASAL METABOLISM; CROSS-OVER STUDIES; EMULSIONS; ENERGY METABOLISM; GLUCOSE CLAMP TECHNIQUE; HEALTH; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN; MALE; METABOLIC CLEARANCE RATE; OXIDATION-REDUCTION; TRIGLYCERIDES; YOUNG ADULT;

EID: 84856113031     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2011.06.011     Document Type: Article

References (29)

1. J.M. Kinney Metabolic responses of the critically ill patient Crit Care Clin 11 1995 569 585
2. G. Boden, F. Jadali, and J. White Effects of fat on insulin-stimulated carbohydrate metabolism in normal men J Clin Invest 88 1991 960 966
3. G. Boden, and X. Chen Effects of fat on glucose uptake and utilization in patients with non-insulin dependent diabetes J Clin Invest 96 1995 1261 1268
4. D. Thiébaud, R. DeFronzo, and E. Jacot Effect of long chain triglyceride infusion on glucose metabolism in man Metabolism 31 1982 1128 1136 (Pubitemid 13233916)
5. E. Ferrannini, E. Barett, S. Bevilaquas, and R. DeFronzo Effect of fatty acids on glucose production and utilization in man J Clin Invest 72 1983 1737 1747 (Pubitemid 14229053)
6. B. Wolf, S. Klein, and E. Peters Effect of elevated free fatty acids on glucose oxidation in normal humans Metabolism 37 1988 323 329
7. P. Randle, P. Garland, and C. Hales The glucose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus Lancet 1 1963 785 789
8. L. Sidossis, and R. Wolfe Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed Am J Physiol 270 1996 E733 E738
9. L. Sidossis, B. Mittendorfer, and D. Chinkes Effect of hyperglycemia-hyperinsulinemia on whole body and regional fatty acid metabolism Am J Physiol 276 1999 E427 E434
10. L. Sidossis, C. Stuart, and G. Shulman Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria J Clin Invest 98 1996 2244 2250 (Pubitemid 26394197)
11. L. Groop, R. Bonadonna, and M. Shank Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man J Clin Invest 87 1991 83 89
12. W. Åberg, A. Thörne, and T. Olivecrona Fat oxidation and plasma removal capacity of an intravenous fat emulsion in elderly and young men Nutrition 22 2006 738 743 (Pubitemid 43947504)
13. J. Nordenström, A. Thörne, and W. Åberg The hypertriglyceridemic clamp technique. Studies using long-chain and structured triglyceride emulsions in healthy subjects Metabolism 55 2006 1443 1450 (Pubitemid 44559684)
14. R. DeFronzo, J. Tobin, and R. Andres Glucose clamp technique: a method for quantifying insulin secretion and resistance Am J Physiol 237 1979 E214 E223
15. J. Livessy, S. Hodgkinson, and H. Roud Effect of time, temperature and freezing on the stability of immunoreactive LH, FSH, TSH, growth hormone, prolactin and insulin in plasma Clin Biochem 13 1980 151 155 (Pubitemid 11221681)
16. A.W. Wahlefeld Triglycerides. Determination after enzymatic hydrolysis H.V. Bergmeyer, 2nd ed Methods of enzymatic analysis 4 1974 Verlag Chemie Weinheim. Academic Press, Inc New York 1831 1835
17. J. Hellmér, P. Arner, and A. Lundin Automatic luminometric kinetic assay of glycerol for lipolysis studies Anal Biochem 177 1989 132 137 (Pubitemid 19081734)
18. K. Wildenhoff A micro-method for the enzymatic determination of acetoacetate and 3-hydroxybutyrate in blood and urine Scan J Clin Lab Invest 25 1970 171 179
19. H. Hallman, L.O. Farnebo, and B. Hamberger A sensitive method for the determination of plasma catecholamines using liquid chromatography with electrochemical detection Life Sci 23 1978 1049 1052
20. J.v. Passonneau Fluorimetric method. Determination after enzymatic hydrolysis H.V. Bergmeyer, 2nd ed Methods of enzymatic analysis 3 1974 Verlag Chemie Weinheim. Academic Press, Inc New York 1468 1472
21. S.B. Nadler, J.U. Hildago, and T. Bloch Prediction of blood volume in normal human adults Surgery 51 1962 224 232
22. S. Bursztein, D. Elwyn, and J. Askanazi Energy metabolism, indirect calorimetry and nutrition 1989 Williams& Wilkins Baltimore (MD)
23. B. Goodpaster, R. Wolfe, and D. Kelley Effects of obesity on substrate utilization during exercise Obesity Res 10 2002 575 584 (Pubitemid 135688254)
24. B. Mittendorfer, B. Patterson, and S. Klein VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity Am J Physiol Endocrinol Metab 284 2003 E708 E715
25. J. Nordenström, Y. Carpentier, and J. Askanazi Free fatty acid mobilization and oxidation during total parenteral nutrition in trauma and sepsis Ann Surg 198 1983 725 735 (Pubitemid 14202749)
26. K.N. Frayn, P. Arner, and H. Yki-Järvinen Fatty acid metabolism in adipose tissue, muscle and liver in healthy and disease Essays Biochem 42 2006 89 103
27. D. Kelley, M. Mokan, and J.A. Simoneau Interaction between glucose and free fatty acid metabolism in human skeletal muscle J Clin Invest 92 1993 91 98 (Pubitemid 23208984)
28. R.R. Wolfe, and E.J. Peters Lipolytic response to glucose infusion in human subjects Am J Physiol 252 1987 E218 E223
29. U. Keller, P. Gerber, and W. Stauffacher Fatty acid-independent inhibition of hepatic ketone body production by insulin in humans Am J Physiol 254 1988 E694 E699