Relationship of endothelial nitric oxide synthase (eNOS) gene polymorphisms with diabetic retinopathy in Caucasians with type 2 diabetes

Ophthalmic Genetics

Volumn 33, Issue 1, 2012, Pages 23-27

  Santos, Ktia G ^a,b   Crispim, Daisy ^b   Canani, Luís H ^b   Ferrugem, Paula T ^a   Gross, Jorge L ^b   Roisenberg, Israel ^c  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

diabetic retinopathy; endothelial nitric oxide synthase (eNOS); polymorphism; Type 2 diabetes

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VARIABLE NUMBER OF TANDEM REPEAT;

BRAZIL; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPING TECHNIQUES; HUMANS; INTRONS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; NITRIC OXIDE SYNTHASE TYPE III; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84856108524     PISSN: 13816810     EISSN: 17445094     Source Type: Journal    
DOI: 10.3109/13816810.2011.620057     Document Type: Article

References (24)

1. Abhary S, Hewitt AW, Burdon KP, Craig JE. A systematic meta-analysis of genetic association studies for diabetic retinopathy. Diabetes 2009;58:2137-2147.
2. Toda N, Nakanishi-Toda M. Nitric oxide: ocular blood flow, glaucoma, and diabetic retinopathy. Prog Retin Eye Res 2007;26:205-238. (Pubitemid 46498800)
3. Li Q, Verma A, Han PY, et al. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci 2010;51:5240-5246.
4. Rao AA, Thota H, Gumpeny RS, et al. Bioinformatics analysis of diabetic retinopathy using functional protein sequences. Med Hypotheses 2008;70:148-155. (Pubitemid 350161150)
5. Chen Y, Huang H, Zhou J, et al. Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans. Mol Vis 2007;13:2142-2147. (Pubitemid 350200388)
6. Ezzidi I, Mtiraoui N, Mohamed MBH, Mahjoub T, Kacem M, Almawi WY. Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene variants with diabetic nephropathy. J Diabetes Complications 2008;22:331-338.
7. Cai H, Wang X, Colagiuri S, Wilcken DEL. A common Glu298?Asp (894G?T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes. Diabetes Care 1998;21:2195-2196. (Pubitemid 28549178)
8. Ukkola O, Erkkilä PH, Savolainen MJ, Kesäniemi YA. Lack of association between polymorphisms of catalase, copperzinc superoxide dismutase (SOD), extracellular SOD and endothelial nitric oxide synthase genes and macroangiopathy in patients with type 2 diabetes mellitus. J Intern Med 2001;249:451-459. (Pubitemid 34208949)
9. Degen B, Schmidt S, Ritz E. A polymorphism in the gene for the endothelial nitric oxide synthase and diabetic nephropathy. Nephrol Dial Transplant 2001;16:185. (Pubitemid 32051503)
10. Petrovic MG, Cilensek I, Petrovic D. Manganese superoxide dismutase gene polymorphism (V16A) is associated with diabetic retinopathy in Slovene (Caucasians) type 2 diabetes patients. Dis Markers 2008;24:59-64. (Pubitemid 350174571)
11. Mehrab-Mohseni M, Tabatabaei-Malazy O, Hasani-Ranjbar S, et al. Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with type 2 diabetes and its chronic complications. Diabetes Res Clin Pract 2011;91:348-352.
12. Suganthalakshmi B, Anand R, Kim R, et al. Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy. Mol Vis 2006;12:336-341.
13. Uthra S, Raman R, Mukesh BN, et al. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Ophthalmic Genet 2007;28:77-81. (Pubitemid 46904764)
14. Neugebauer S, Baba T, Watanabe T. Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes. Diabetes 2000;49:500-503. (Pubitemid 30131798)
15. Ohtoshi K, Yamasaki Y, Gorogawa S, et al. Association of-786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance. Diabetologia 2002;45:1594-1601. (Pubitemid 35352054)
16. Shimizu T, Onuma T, Kawamori R, Makita Y, Tomino Y. Endothelial nitric oxide synthase gene and the development of diabetic nephropathy. Diabetes Res Clin Pract 2002;58:179-185. (Pubitemid 36159014)
17. Awata T, Neda T, Iizuka H, et al. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Diabetes Care 2004;27:2184-2190. (Pubitemid 39167183)
18. De Syllos RWC, Sandrim VC, Lisboa HRK, Tres GS, Tanus- Santos JE. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. Nitric Oxide 2006;15:417-422. (Pubitemid 44649283)
19. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2005;28:S37-S42.
20. Wilkinson CP, Ferris FL 3rd, Klein RE, et al., Global Diabetic Retinopathy Project Group. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003;110:1677-1682. (Pubitemid 37025422)
21. Lahiri DK, Nurnberger JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies, Nucleic Acids Res 1991;19:5444.
22. Santos KG, Crispim D, Canani LH, Ferrugem PT, Gross JL, Roisenberg I. Association of eNOS gene polymorphisms with renal disease in Caucasians with type 2 diabetes. Diabetes Res Clin Pract 2011;91:353-362.
23. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-989. (Pubitemid 32289743)
24. Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing data imputation, Am J Hum Genet 2005;76:449-462 (Pubitemid 40250525)