Powerful approach to heterocyclic skeletal diversity by sequential three-component reaction of amines, isothiocyanates, and 1,2-diaza-1,3-dienes

Journal of Organic Chemistry

Volumn 77, Issue 2, 2012, Pages 1161-1167

  Attanasi, Orazio A ^a   Bartoccini, Silvia ^a   Favi, Gianfranco ^a   Giorgi, Gianluca ^b   Perrulli, Francesca Romana ^a   Santeusanio, Stefania ^a  

^a UNIVERSITY OF URBINO   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CORE FORMATION; HETEROCYCLES; HYDRAZONES; ISOTHIOCYANATES; KEY FEATURE; MICHAEL ADDITIONS; ONE POT; PRIMARY AMINES; REGIO-SELECTIVE; SIDE-CHAINS; THREE COMPONENT REACTIONS;

ADDITION REACTIONS; OLEFINS;

AMINES;

1 (1 ALLYL 3 BENZYL 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL)ETHAN 1 ONE SEMICARBAZONE; 1 (1 BENZYL 3 BUTYL 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL)ETHAN 1 ONE SEMICARBAZONE; 1 (3 ALLYL 1 BENZYL 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL)ETHAN 1 ONE; 1 (3 BENZYL 1 BUTYL 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL)ETHAN 1 ONE SEMICARBAZONE; 1 (5 OXO 1 PHENY1 3 PROPYL 2 THIOXOIMIDAZOLIDIN 4 YL)ETHAN 1 ONE SEMICARBAZONE; 1 [3 ALLYL 1 (4 CHLOROPHENYL) 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL)] ETHAN 1 ONE SEMICARBAZONE; 1 [3 BENZYL 1 (4 CHLOROPHENYL) 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL] ETHAN 1-ONE N PHENYLSEMICARBAZONE; 1 BUTYL 5 (1 HYDROXYETHYLIDENE) 3 PHENYL 2 THIOXOIMIDAZOLIDIN 4 ONE; 1,2 DIAZA 1,3 DIENE DERIVATIVE; 2 [1 [3 ALLYL 2 [(4 CHLOROPHENYL)IMINO] 4 OXO 1,3 THIAZOLIDIN 5 YLIDENE]ETHYL]HYDRAZINECARBOXAMIDE; 2 [1 [3 BENZYL 2 [(1 (4 CHLOROPHENYL)IMINO] 4 OXO 1,3 THIAZOLIXOIMIDAZOLIDIN 4 ONE; 2 IMINOTHIAZOLIDIN 4 ONE; 3 BENZYL 5 (1 HYDROXYETHYLIDENE) 2 [(4 METHOXYPHENYL)IMINO] 1,3 THIAZOLIDIN 4 ONE; 3 BUTYL 5 (1 HYDROXYETHYLIDENE) 2 (PHENYLIMINO) 1,3 THIAZOLIDIN 4 ONE; 5 HYDRAZINOETHYLIDENE 2 IMINOTHIAZOLIDIN 4 ONE; 5 HYDROXYETHYLIDENE THIOHYDANTOIN DERIVATIVE; AMINE; ISOTHIOCYANIC ACID DERIVATIVE; METHYL 2 [1 (3 BUTYL 5 OXO 1 PHENYL 2 THIOXOIMIDAZOLIDIN 4 YL) ETHYLIDENE]HYDRAZINECARBOXYLATE; METHYL 2 [1 [3 ALLYL 1 (4 METHOXYPHENYL) 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL]ETHYLIDENE]HYDRAZINECARBOXYLATE; METHYL 2 [1 [3 BUTYL 4 OXO 2 (PHENYLIMINO) 1,3 THIAZOLIDIN 5 YLIDENE]ETHYL]HYDRAZINECARBOXYLATE; REAGENT; TERT BUTYL 2 [(3 BENZYL 5 OXO 1 PHENYL 2 THIOXOIMIDAZOLIDIN 4 YL)(PHENYL)METHYLENE]HYDRAZINECARBOXYLATE; TERT BUTYL 2 [1 [3 BENZYL 1 (4 METHOXYPHENYL) 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL]ETHYLIDENE]HYDRAZINECARBOXYLATE; TERT BUTYL 2 [1 [3 BENZYL 2 [(4 METHOXYPHENYL)IMINO] 4 OXO 1,3 THIAZOLIDIN 5 YLIDENE]ETHYL]HYDRAZINECARBOXYLATE; TERT BUTYL 2 [1 [3 BUTYL 1 (4 CHLOROPHENYL) 5 OXO 2 THIOXOIMIDAZOLIDIN 4 YL]ETHYLILENE]HYDRAZINECARBOXYLATE; THIAZOLE; THIOHYDANTOIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; MICHAEL ADDITION; ONE POT SYNTHESIS;

AMINES; CHEMISTRY TECHNIQUES, SYNTHETIC; HETEROCYCLIC COMPOUNDS; HYDANTOINS; ISOTHIOCYANATES; MOLECULAR STRUCTURE; POLYENES; STEREOISOMERISM;

EID: 84856091901     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo2021949     Document Type: Article

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