Suppression of Gαs synthesis by simvastatin treatment of vascular endothelial cells

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2643-2651

  Kou, Ruqin ^a   Shiroto, Takashi ^a   Sartoretto, Juliano L ^a   Michel, Thomas ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRITICAL DETERMINANT; FLUORESCENCE RESONANCE ENERGY TRANSFER; GERANYLGERANYLATION; ISOPROTERENOL; MEVALONATE; PROTEIN STABILITY; SIGNALING PATHWAYS; SIMVASTATIN; SIMVASTATIN TREATMENT; STATINS; VASCULAR ENDOTHELIAL CELLS; VASCULAR WALL; VASORELAXATION;

AMINO ACIDS; BIOSENSORS; ENERGY TRANSFER; FLUORESCENCE; PHOSPHORYLATION;

ENDOTHELIAL CELLS;

CARBACHOL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIN; GERANYLGERANYL PYROPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INITIATION FACTOR 4A; INITIATION FACTOR 4E BINDING PROTEIN 1; ISOPRENALINE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MEVALONIC ACID; PROTEIN KINASE B; RAP1 PROTEIN; SERINE; SIMVASTATIN; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; BIOCHEMISTRY; BIOSENSOR; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ANIMALS; CATTLE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME STABILITY; GTP-BINDING PROTEIN ALPHA SUBUNITS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIMVASTATIN; TOR SERINE-THREONINE KINASES;

MUS;

EID: 84856078015     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.303594     Document Type: Article

References (22)

1. Ponsioen, B., Zhao, J., Riedl, J., Zwartkruis, F., van der Krogt, G., Zaccolo, M., Moolenaar, W. H., Bos, J. L., and Jalink, K. (2004) Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep. 5, 1176-1180 (Pubitemid 40103613)
2. Jain, M. K., and Ridker, P. M. (2005) Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat. Rev. Drug Discov. 4, 977-987
3. Mühlhäuser, U., Zolk, O., Rau, T., Münzel, F., Wieland, T., and Eschenhagen, T. (2006) Atorvastatin desensitizes β-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein γ-subunits. FASEB J. 20, 785-787 (Pubitemid 46671215)
4. Kou, R., Sartoretto, J., and Michel, T. (2009) Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-β. J. Biol. Chem. 284, 14734-14743
5. Igarashi, J., Bernier, S. G., and Michel, T. (2001) Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J. Biol. Chem. 276, 12420-12426
6. Michel, T., Li, G. K., and Busconi, L. (1993) Phosphorylation and subcellular translocation of endothelial nitric-oxide synthase. Proc. Natl. Acad. Sci. U.S.A. 90, 6252-6256 (Pubitemid 23191493)
7. Kou, R., Greif, D., and Michel, T. (2002) Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. J. Biol. Chem. 277, 29669-29673
8. Kou, R., Igarashi, J., and Michel, T. (2002) Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase. Biochemistry 41, 4982-4988 (Pubitemid 34298666)
9. Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) Method. Methods 25, 402-408 (Pubitemid 34164012)
10. Moens, A. L., Yang, R., Watts, V. L., and Barouch, L. A. (2010) β3-adrenoreceptor regulation of nitric oxide in the cardiovascular system. J. Mol. Cell Cardiol. 48, 1088-1095
11. Gloerich, M., and Bos, J. L. (2010) Epac: defining a new mechanism for cAMP action. Annu. Rev. Pharmacol. Toxicol. 50, 355-375
12. Namiecinska, M., Wiktorowska-Owczarek, A., Loboda, A., Dulak, J., and Nowak, J. Z. (2006) Cyclic AMP generating system in human microvascular endothelium is highly responsive to adrenaline. Pharmacol. Rep. 58, 884-889 (Pubitemid 46117740)
13. Lilja, J. J., Kivistö, K. T., and Neuvonen, P. J. (1998) Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin. Pharmacol. Ther. 64, 477-483 (Pubitemid 28531591)
14. Gingras, A. C., Raught, B., and Sonenberg, N. (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68, 913-963 (Pubitemid 29449212)
15. Bhandari, B. K., Feliers, D., Duraisamy, S., Stewart, J. L., Gingras, A. C., Abboud, H. E., Choudhury, G. G., Sonenberg, N., and Kasinath, B. S. (2001) Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney Int. 59, 866-875 (Pubitemid 32206849)
16. Senthil, D., Faulkner, J. L., Choudhury, G. G., Abboud, H. E., and Kasinath, B. S. (2001) Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E-binding protein-1 in proximal tubular epithelial cells. Biochem. J. 360, 87-95 (Pubitemid 33081952)
17. Brunn, G. J., Hudson, C. C., Sekuli, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T. (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277, 99-101 (Pubitemid 27450655)
18. Beretta, L., Gingras, A. C., Svitkin, Y. V., Hall, M. N., and Sonenberg, N. (1996) Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 15, 658-664 (Pubitemid 26044579)
19. Pause, A., Belsham, G. J., Gingras, A. C., Donzé, O., Lin, T. A., Lawrence, J. C., Jr., and Sonenberg, N. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371, 762-767
20. Comerford, K. M., Lawrence, D. W., Synnestvedt, K., Levi, B. P., and Colgan, S. P. (2002) Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J. 16, 583-585
21. Schmechel, A., Grimm, M., El-Armouche, A., Höppner, G., Schwoerer, A. P., Ehmke, H., and Eschenhagen, T. (2009) Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects. Cardiovasc Res. 82, 100-106
22. Stenestrand, U., and Wallentin, L. (2001) Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 285, 430-436 (Pubitemid 32097261)