The many faces of MeCP2

Neuropsychopharmacology

Volumn 37, Issue 2, 2012, Pages 313-314

  McGinty, Jacqueline F ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; HISTONE DEACETYLASE; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID; TRANSCRIPTION FACTOR SIN3A;

CALCIUM TRANSPORT; CHROMATIN; CORPUS STRIATUM; CPG ISLAND; DNA METHYLATION; GENETIC TRANSCRIPTION; HISTONE METHYLATION; HUMAN; INTERNEURON; LIMBIC CORTEX; LOCOMOTION; MEMBRANE DEPOLARIZATION; NOTE; NUCLEUS ACCUMBENS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANIMALS; BRAIN; DOPAMINE; GENE EXPRESSION REGULATION; MALE; METHYL-CPG-BINDING PROTEIN 2; SEROTONIN;

EID: 84856043779     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.246     Document Type: Note

References (8)

1. Chahrour M, Jung SY, Shaw C, Zhou X, Wong STC, Qin J et al (2008). MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320: 1224-1229. (Pubitemid 351929512)
2. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC et al (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302: 885-889. (Pubitemid 37339632)
3. Deng JV, Rodruiguez RM, Hutchinson AN, Kim I-H, Wetsel WC, West AE (2010). MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nature Neurosci 9: 1128-1138.
4. Hutchinson AN, Deng JV, Aryal DK, Wetsel WC, West AE (2011). Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology 37: 321-337.
5. Im H-I, Hollander JA, Bali P, Kenny PJ (2010). MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nature Neurosci 13: 1120-1127.
6. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y et al (2003). DNA methylation-related chromatin remodeling in activitydependent Bdnf gene regulation. Science 302: 890-893. (Pubitemid 37339633)
7. Skene PJ, Illingworth RS, Webb S, Kerr ARW, James KD, Turner DJ et al (2010). Neuronal MeCP2 Is expressed at near histoneoctamer levels and globally alters the chromatin state. Mol Cell 37: 457-468.
8. Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L et al (2006). Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52: 255-269. (Pubitemid 44548348)