Neurorepair with mesenchymal stem cells: Hope or hype?

The Lancet Neurology

Volumn 11, Issue 2, 2012, Pages 123-125

  Freedman, Mark S ^a   Uccelli, Antonio ^b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL TRANSDIFFERENTIATION; DEMYELINATION; EVOKED VISUAL RESPONSE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LETTER; MESENCHYMAL STEM CELL; MULTIPLE SCLEROSIS; OPTIC NERVE; PARACRINE SIGNALING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RECURRENT DISEASE; VISUAL SYSTEM;

FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; TRANSPLANTATION, AUTOLOGOUS; VISION DISORDERS;

EID: 84855995244     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(12)70001-7     Document Type: Letter

References (6)

1. Uccelli A, Laroni A, Freedman MS Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases. Lancet Neurol 2011, 10:649-656.
2. Connick P, Kolappan M, Crawley C, et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012, published online Jan 10. 10.1016/S1474-4422(11)70305-2.
3. Barkhof F, Calabresi PA, Miller DH, Reingold SC Imaging outcomes for neuroprotection and repair in multiple sclerosis trials. Nat Rev Neurol 2009, 5:256-266.
4. Chen JT, Kuhlmann T, Jansen GH, et al. Voxel-based analysis of the evolution of magnetization transfer ratio to quantify remyelination and demyelination with histopathological validation in a multiple sclerosis lesion. Neuroimage 2007, 36:1152-1158.
5. Uccelli A, Frassoni F, Mancardi G Stem cells for multiple sclerosis: promises and reality. Regen Med 2007, 2:7-9.
6. Freedman MS, Bar-Or A, Atkins HL, et al. The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group. Mult Scler 2010, 16:503-510.