Overexpression of ROM-1 in the cone-dominant retina

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 633-639

  Chakraborty, Dibyendu ^a   Conley, Shannon M ^a   Nash, Zack ^a   Ding, Xi Qin ^a   Naash, Muna I ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Cone; Mouse Models; Nrl; RDS; ROM 1; Transgene

Indexed keywords

ROD OUTER SEGMENT MEMBRANE PROTEIN 1; TETRASPANIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL VACUOLE; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRORETINOGRAPHY; GEL ELECTROPHORESIS; MOUSE; NONHUMAN; PHOTOPIC VISION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA CONE; RETINA DEGENERATION; RETINA ROD OUTER SEGMENT; TISSUE STRUCTURE; TRANSGENIC MOUSE; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; DISEASE MODELS, ANIMAL; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL DISEASES; ROD CELL OUTER SEGMENT; TRANSGENES;

EID: 84855975887     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_80     Document Type: Conference Paper

References (18)

1. Bascom RA, Manara S, Collins L et al (1992) Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies. Neuron 8:1171-1184
2. Chakraborty D, Ding XQ, Fliesler SJ et al (2008) Outer segment oligomerization of rds: evidence from mouse models and subcellular fractionation. Biochemistry 47:1144-1156 (Pubitemid 351161871)
3. Chakraborty D, Conley SM, Stuck MW et al (2010) Differences in RDS trafficking, assembly, and function in cones vs. rods: Insights from studies of C150S-RDS. Hum Mol Genet 19:4799-4812
4. Chakraborty D, Ding XQ, Conley SM et al (2009) Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet 18:797-808
5. Cheng T, Peachey NS, Li S et al (1997) The effect of peripherin/rds haploinsufficiency on rod and cone photoreceptors. J Neurosci 17:8118-8128 (Pubitemid 27461036)
6. Clarke G, Goldberg AF, Vidgen D et al (2000) Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Nat Genet 25:67-73 (Pubitemid 30257039)
7. Ding XQ, Nour M, Ritter LM et al (2004) The R172W mutation in peripherin/rds causes a conerod dystrophy in transgenic mice. Hum Mol Genet 13:2075-2087 (Pubitemid 39377830)
8. Farjo R, Skaggs JS, Nagel BA et al (2006) Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors. J Cell Biology 173:59-68
9. Goldberg AF, Molday RS (1996) Subunit composition of the peripherin/rds-rom-1 disk rim complex from rod photoreceptors: hydrodynamic evidence for a tetrameric quaternary structure. Biochemistry 35:6144-6149 (Pubitemid 26147587)
10. Goldberg AF, Moritz OL, Molday RS (1995) Heterologous expression of photoreceptor peripherin/rds and Rom-1 in COS-1 cells: assembly, interactions, and localization of multisubunit complexes. Biochemistry 34:14213-14219
11. Goldberg AF, Loewen CJ, Molday RS (1998) Cysteine residues of photoreceptor peripherin/rds: role in subunit assembly and autosomal dominant retinitis pigmentosa. Biochemistry 37: 680-685 (Pubitemid 28123802)
12. Kedzierski W, Moghrabi WN, Allen AC et al (1996) Three homologs of rds/peripherin in Xenopus laevis photoreceptors that exhibit covalent and non-covalent interactions. J Cell Sci 109 ( Pt 10): 2551-2560 (Pubitemid 26377530)
13. Li C, Ding XQ, O'Brien J et al (2003) Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues. Invest Ophthalmol Vis Sci 44:2433-2441 (Pubitemid 36618398)
14. Loewen CJ, Molday RS (2000) Disulfide-mediated oligomerization of Peripherin/Rds and Rom-1 in photoreceptor disk membranes. Implications for photoreceptor outer segment morphogenesis and degeneration. J Biol Chem 275:5370-5378 (Pubitemid 30115167)
15. Moritz OL, Molday RS (1996) Molecular cloning, membrane topology, and localization of bovine rom-1 in rod and cone photoreceptor cells. Invest Ophthalmol Vis Sci 37:352-362 (Pubitemid 26057061)
16. Naash MI, Hollyfield JG, al-Ubaidi MR et al (1993) Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci USA 90:5499-5503 (Pubitemid 23176188)
17. Nour M, Ding XQ, Stricker H et al (2004) Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression. Invest Ophthalmol Vis Sci 45:2514-2521 (Pubitemid 38998844)
18. Stricker HM, Ding XQ, Quiambao A et al (2005) The Cys214 - > Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem J 388:605-613 (Pubitemid 40839938)