A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib

Tetrahedron Letters

Volumn 53, Issue 8, 2012, Pages 948-951

  Fussell, Steven J ^a   Luan, Amy ^a   Peach, Philip ^a   Scotney, Gemma ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Hydrogenation; Iodination; Nucleophilic aromatic substitution; Palladium; Piperidine

Indexed keywords

4 (4 IODO 1H PYRAZOL 1 YL)PIPERIDINE; CRIZOTINIB; IODINE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; HYDROGENATION; IODINATION; NUCLEOPHILICITY; PROCESS OPTIMIZATION; REACTION ANALYSIS; SCALE UP; SUBSTITUTION REACTION; SYNTHESIS;

EID: 84855953136     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.12.044     Document Type: Article

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