HIF-1α is a major and complex player in alcohol induced liver diseases

Journal of Hepatology

Volumn 56, Issue 2, 2012, Pages 311-312

  Mehal, Wajahat Z ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 9; PARACETAMOL; RANTES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ALCOHOL LIVER DISEASE; ANGIOGENESIS; DIET; EDITORIAL; FATTY ACID OXIDATION; FATTY LIVER; GENE EXPRESSION; HEPATITIS; HYPERTRIGLYCERIDEMIA; LIPID LIVER LEVEL; LIPID METABOLISM; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER WEIGHT; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ANIMALS; FATTY LIVER, ALCOHOLIC; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIPID METABOLISM; MALE;

EID: 84855932690     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.09.009     Document Type: Editorial

References (15)

1. C.S. Lieber Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis Alcohol 34 2004 9 19 (Pubitemid 40163989)
2. H. Tsukamoto, and X.P. Xi Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis Hepatology 9 1989 302 306 (Pubitemid 19063318)
3. O. Rosmorduc, and C. Housset Hypoxia: a link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease Semin Liver Dis 30 2010 258 270
4. P. Jaakkola, D.R. Mole, Y.M. Tian, M.I. Wilson, J. Gielbert, and S.J. Gaskell Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 292 2001 468 472 (Pubitemid 32335942)
5. N. Yasumasa, G. Nobuhito, K. Mai, N. Daisuke, O. Kota, and Y. Yu HIF-1a induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice J Hepatol 56 2011 441 447
6. B. Nath, I. Levin, T. Csak, J. Petrasek, C. Mueller, and K. Kodys Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice Hepatology 53 2011 1526 1537
7. M.S. Wiesener, J.S. Jurgensen, C. Rosenberger, C.K. Scholze, J.H. Horstrup, and C. Warnecke Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs FASEB J 17 2003 271 273
8. H. Nakagawa, S. Maeda, Y. Hikiba, T. Ohmae, W. Shibata, and A. Yanai Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen- induced liver injury by inhibiting c-Jun N-terminal kinase activation Gastroenterology 135 2008 1311 1321
9. M. Bourdi, J.S. Davies, and L.R. Pohl Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury Chem Res Toxicol 24 2011 794 796
10. E. Elinav, T. Strowig, A.L. Kau, J. Henao-Mejia, C.A. Thaiss, and C.J. Booth NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis Cell 145 2011 745 757
11. S.M. Yeligar, K. Machida, H. Tsukamoto, and V.K. Kalra Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol 183 2009 5964 5976
12. S. Yeligar, H. Tsukamoto, and V.K. Kalra Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol 183 2009 5232 5243
13. J.O. Moon, T.P. Welch, F.J. Gonzalez, and B.L. Copple Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice Am J Physiol Gastrointest Liver Physiol 296 2009 G582 G592
14. N. Zhang, Z. Fu, S. Linke, J. Chicher, J.J. Gorman, and D. Visk The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism Cell Metab 11 2010 364 378
15. R.J. Fontana, P.B. Watkins, H.L. Bonkovsky, N. Chalasani, T. Davern, and J. Serrano Drug-Induced Liver Injury Network (DILIN) prospective study: rationale, design and conduct Drug Saf 32 2009 55 68