Associations of HLA-shared epitope, anti-citrullinated peptide antibodies and lifestyle-related factors in Hungarian patients with rheumatoid arthritis: Data from the first Central-Eastern European cohort

Joint Bone Spine

Volumn 78, Issue 6, 2011, Pages 652-653

  Besenyei, Timea ^a   Gyetvai, Ágnes ^a   Szabó, Zoltán ^a   Fekete, Andrea ^a   Kapitány, Anikó ^a   Szodoray, Péter ^b   Laki, Judit ^c   Soós, Lilla ^a   Sipka, Sándor ^a   Szegedi, Gyula ^d   Lakos, Gabriella ^a,e   Szekanecz, Zoltán ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF OSLO   (Norway)

^c NATIONAL MEDICAL CENTER   (Hungary)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e Thera Test laboratories Inc   (United States)

Author keywords

Alcohol; Anti CCP; Anti citrullinated protein antibodies; Rheumatoid arthritis; Rheumatoid factor; Shared epitope; Smoking

Indexed keywords

AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HLA ANTIGEN; HLA DRB1 ANTIGEN; IMMUNOGLOBULIN G; ORAL CONTRACEPTIVE AGENT;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ANTIBODY DETECTION; CIGARETTE SMOKING; COFFEE; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EUROPE; FEMALE; HUMAN; HUNGARY; LETTER; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; ORAL CONTRACEPTION; POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RISK FACTOR;

EID: 84855928565     PISSN: 1297319X     EISSN: 17787254     Source Type: Journal    
DOI: 10.1016/j.jbspin.2011.05.018     Document Type: Letter

References (10)

1. van der Helm-van Mil A.H., Wesoly J.Z., Huizinga T.W. Understanding the genetic contribution to rheumatoid arthritis. Curr Opin Rheumatol 2005, 17:299-304.
2. Padyukov L., Silva C., Stolt P., et al. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004, 50:3085-3092.
3. Gregersen P.K., Silver J., Winchester R.J. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987, 30:1205-1213.
4. Szekanecz Z., Soos L., Szabo Z., et al. Anti-citrullinated protein antibodies in rheumatoid arthritis: as good as it gets?. Clin Rev Allergy Immunol 2008, 34:26-31.
5. Szodoray P, Szabo Z, Kapitany A, et al. Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis. Autoimmun Rev 2010;9(3):140-3.
6. Klareskog L., Widhe M., Hermansson M., et al. Antibodies to citrullinated proteins in arthritis: pathology and promise. Curr Opin Rheumatol 2008, 20:300-305.
7. Morgan A.W., Thomson W., Martin S.G., et al. Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum 2009, 60:2565-2576.
8. du Montcel S.T., Michou L., Petit-Teixeira E., et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005, 52:1063-1068.
9. Gyetvai A., Szekanecz Z., Soos L., et al. New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies. Rheumatology (Oxford) 2010, 49:25-33.
10. Pedersen M., Jacobsen S., Klarlund M., et al. Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Res Ther 2006, 8:R133.