Detection of foot-and-mouth disease virus RNA in pharyngeal epithelium biopsy samples obtained from infected cattle: Investigation of possible sites of virus replication and persistence

Veterinary Microbiology

Volumn 154, Issue 3-4, 2012, Pages 230-239

  Stenfeldt, Carolina ^a   Belsham, Graham J ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Bovine; Foot and mouth disease; Pathogenesis; QRT PCR; Virus

Indexed keywords

VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; FOOT AND MOUTH DISEASE VIRUS; LARYNGEAL BIOPSY; LYMPH NODE; NONHUMAN; OROPHARYNX; PHARYNX MUCOSA; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOFT PALATE; VIRUS DETECTION; VIRUS GENOME; VIRUS REPLICATION;

ANIMALS; BODY FLUIDS; CATTLE; CATTLE DISEASES; EPITHELIUM; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; OROPHARYNX; PALATE, SOFT; PHARYNX; RNA; RNA, VIRAL; VIRUS REPLICATION;

ANIMALIA; BOS; BOVINAE; FOOT-AND-MOUTH DISEASE VIRUS;

EID: 84855920777     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2011.07.007     Document Type: Article

References (30)

1. Alexandersen S., Mowat N. Foot-and-mouth disease: host range and pathogenesis. Curr. Top. Microbiol. Immunol. 2005, 288:9-42.
2. Alexandersen S., Oleksiewicz M.B., Donaldson A.I. The early pathogenesis of foot-and-mouth disease in pigs infected by contact: a quantitative time-course study using TaqMan RT-PCR. J. Gen. Virol. 2001, 82:747-755.
3. Alexandersen S., Quan M., Murphy C., Knight J., Zhang Z. Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. J. Comp. Pathol. 2003, 129:268-282.
4. Alexandersen S., Zhang Z., Donaldson A.I. Aspects of the persistence of foot-and-mouth disease virus in animals-the carrier problem. Microbes Infect. 2002, 4:1099-1110.
5. Alexandersen S., Zhang Z., Donaldson A.I., Garland A.J. The pathogenesis and diagnosis of foot-and-mouth disease. J. Comp. Pathol. 2003, 129:1-36.
6. Arzt J., Juleff N., Zhang Z., Rodriguez L.L. The pathogenesis of foot-and-mouth disease I: viral pathways in cattle. Transbound. Emerg. Dis. 2011, 58:291-304.
7. Arzt J., Pacheco J.M., Rodriguez L.L. The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation: identification of the nasopharynx as the primary site of infection. Vet. Pathol. 2010, 47:1048-1063.
8. Balinda S.N., Tjornehoj K., Muwanika V.B., Sangula A.K., Mwiine F.N., Ayebazibwe C., Masembe C., Siegismund H.R., Alexandersen S. Prevalence estimates of antibodies towards foot-and-mouth disease virus in small ruminants in Uganda. Transbound. Emerg. Dis. 2009, 56:362-371.
9. Belsham G.J. Translation and replication of FMDV RNA. Curr. Top. Microbiol. Immunol. 2005, 288:43-70.
10. Brown C.C., Meyer R.F., Olander H.J., House C., Mebus C.A. A pathogenesis study of foot-and-mouth disease in cattle, using in situ hybridization. Can. J. Vet. Res. 1992, 56:189-193.
11. Brown C.C., Piccone M.E., Mason P.W., McKenna T.S., Grubman M.J. Pathogenesis of wild-type and leaderless foot-and-mouth disease virus in cattle. J. Virol. 1996, 70:5638-5641.
12. Burrows R. Studies on the carrier state of cattle exposed to foot-and-mouth disease virus. J. Hyg. (Lond.) 1966, 64:81-90.
13. Burrows R., Mann J.A., Garland A.J., Greig A., Goodridge D. The pathogenesis of natural and simulated natural foot-and-mouth disease infection in cattle. J. Comp. Pathol. 1981, 91:599-609.
14. Callahan J.D., Brown F., Rosario F.A., Sure J.H., Kramer E., Long G.W., Labret J., Ellis S.J., Scholars K.S., Gaffney K.L., Rock D.L., Nelson W.M. Use of a portable real-time reverse transcriptase-polymerase chain reaction assay for rapid detection of foot-and-mouth disease virus. J. Am. Vet. Med. Assoc. 2002, 220:1636-1642.
15. Doel T.R., Williams L., Barnett P.V. Emergency vaccination against foot-and-mouth disease: rate of development of immunity and its implications for the carrier state. Vaccine 1994, 12:592-600.
16. Donaldson A.I., Gibson C.F., Oliver R., Hamblin C., Kitching R.P. Infection of cattle by airborne foot-and-mouth disease virus: minimal doses with O1 and SAT 2 strains. Res. Vet. Sci. 1987, 43:339-346.
17. Juleff N., Windsor M., Reid E., Seago J., Zhang Z., Monaghan P., Morrison I.W., Charleston B. Foot-and-mouth disease virus persists in the light zone of germinal centres. PLoS One 2008, 3:e3434.
18. McVicar J.W., Sutmoller P. Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation. J. Hyg. (Lond.) 1976, 76:467-481.
19. Moonen P., Schrijver R. Carriers of foot-and-mouth disease virus: a review. Vet. Q. 2000, 22:193-197.
20. Pacheco J.M., Arzt J., Rodriguez L.L. Early events in the pathogenesis of foot-and-mouth disease in cattle after controlled aerosol exposure. Vet. J. 2010, 183:46-53.
21. Prato Murphy M.L., Meyer R.F., Mebus C., Schudel A.A., Rodriguez M. Analysis of sites of foot and mouth disease virus persistence in carrier cattle via the polymerase chain reaction. Arch. Virol. 1994, 136:299-307.
22. Reid S.M., Ferris N.P., Hutchings G.H., Zhang Z., Belsham G.J., Alexandersen S. Diagnosis of foot-and-mouth disease by real-time fluorogenic PCR assay. Vet. Rec. 2001, 149:621-623.
23. Salt J.S. The carrier state in foot and mouth disease-an immunological review. Br. Vet. J. 1993, 149:207-223.
24. Stenfeldt C., Heegaard P.M., Stockmarr A., Tjornehoj K., Belsham G.J. The acute phase responses of serum amyloid A, haptoglobin and type 1 interferon in cattle experimentally infected with foot-and-mouth disease virus serotype O. Vet. Res. 2011, 42:66. 10.1186/1297-9716-42-66.
25. Stenfeldt, C., Heegaard, P.M., Stockmarr, A., Belsham, G.J., 2011b. Modulation of cytokine mRNA expression in pharyngeal epithelial samples obtained from cattle infected with foot-and-mouth disease virus. J. Comp. Pathol., in press, doi:10.1016/j.jcpa.2011.06.005.
26. Zhang Z., Alexandersen S. Quantitative analysis of foot-and-mouth disease virus RNA loads in bovine tissues: implications for the site of viral persistence. J. Gen. Virol. 2004, 85:2567-2575.
27. Zhang Z., Alexandersen S. Detection of carrier cattle and sheep persistently infected with foot-and-mouth disease virus by a rapid real-time RT-PCR assay. J. Virol. Methods 2003, 111:95-100.
28. Zhang Z., Bashiruddin J.B., Doel C., Horsington J., Durand S., Alexandersen S. Cytokine and toll-like receptor mRNAs in the nasal-associated lymphoid tissues of cattle during foot-and-mouth disease virus infection. J. Comp. Pathol. 2006, 134:56-62.
29. Zhang Z., Murphy C., Quan M., Knight J., Alexandersen S. Extent of reduction of foot-and-mouth disease virus RNA load in oesophageal-pharyngeal fluid after peak levels may be a critical determinant of virus persistence in infected cattle. J. Gen. Virol. 2004, 85:415-421.
30. Zhang Z.D., Kitching R.P. The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx. J. Comp. Pathol. 2001, 124:89-94.