The early pathogenesis of foot-and-mouth disease in cattle after aerosol inoculation: Identification of the nasopharynx as the primary site of infection

Veterinary Pathology

Volumn 47, Issue 6, 2010, Pages 1048-1063

  Arzt, Jonathan ^a,b   Pacheco, J M ^a   Rodriguez, L L ^a  

^a PLUM ISLAND ANIMAL DISEASE CENTER   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

aerosol; bovine; cattle; foot and mouth disease; pathogenesis; virus

Indexed keywords

VIRUS RNA;

AEROSOL; ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CATTLE DISEASE; DISEASE COURSE; FLUORESCENT ANTIBODY TECHNIQUE; FOOT AND MOUTH DISEASE; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; METABOLISM; NASOPHARYNX; PATHOLOGY; VIREMIA; VIROLOGY; VIRUS LOAD;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; CATTLE; CATTLE DISEASES; DISEASE PROGRESSION; FLUORESCENT ANTIBODY TECHNIQUE; FOOT-AND-MOUTH DISEASE; LUNG; MALE; NASOPHARYNX; RNA, VIRAL; VIRAL LOAD; VIREMIA;

ANIMALIA; BOS; BOVINAE; FOOT-AND-MOUTH DISEASE VIRUS;

EID: 78649934913     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1177/0300985810372509     Document Type: Article

References (28)

1. Alexandersen S., Mowat N.: Foot-and-mouth disease: host range and pathogenesis. Curr Top Microbiol Immunol 288:9-42, 2005.
2. Alexandersen S., Zhang Z., Donaldson AI, Garland AJ: The pathogenesis and diagnosis of foot-and-mouth disease. J Comp Pathol 129:1-36, 2003.
3. Arzt J., Gregg DA, Clavijo A., Rodriguez LL: Optimization of immunohistochemical and fluorescent antibody techniques for localization of foot-and-mouth disease virus in animal tissues. J Vet Diagn Invest 21:779-792, 2009.
4. Brown CC, Meyer RF, Olander HJ, House C., Mebus CA: A pathogenesis study of foot-and-mouth disease in cattle, using in situ hybridization. Can J Vet Res 56:189-193, 1992.
5. Brown CC, Olander HJ, Meyer RF: Pathogenesis of foot-and-mouth disease in swine, studied by in-situ hybridization. J Comp Pathol 113:51-58, 1995.
6. Brown CC, Piccone ME, Mason PW, McKenna TS, Grubman MJ: Pathogenesis of wild-type and leaderless foot-and-mouth disease virus in cattle. J Virol 70:5638-5641, 1996.
7. Burrows R., Mann JA, Garland AJ, Greig A., Goodridge D.: The pathogenesis of natural and simulated natural foot-and-mouth disease infection in cattle. J Comp Pathol 91:599-609, 1981.
8. Callahan JD, Brown F., Osorio FA, Sur JH, Kramer E., Long GW, Lubroth J., Ellis SJ, Shoulars KS, Gaffney KL, Rock DL, Nelson WM: Use of a portable real-time reverse transcriptase-polymerase chain reaction assay for rapid detection of foot-and-mouth disease virus. J Am Vet Med Assoc 220:1636-1642, 2002.
9. Caswell J., Williams K. The respiratory system In: Jubb, Kennedy & Palmer's Pathology of Domestic Animals, ed. Maxie MG, 5th ed., pp. 523-653. Saunders, St. Louis, MO, 2007.
10. Eskildsen M.: Experimental pulmonary infection of cattle with foot-and-mouth disease virus. Nord Vet Med 21:86-91, 1969.
11. Frenkel HS: Histologic changes in explanted bovine epithelial tongue tissue infected with the virus of foot-and-mouth disease. Am J Vet Res 10:142-145, 1949.
12. Golde WT, Pacheco JM, Duque H., Doel T., Penfold B., Ferman GS, Gregg DR, Rodriguez LL: Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: use in emergency outbreak response. Vaccine 23:5775-5782, 2005.
13. Grubman MJ, Baxt B.: Foot-and-mouth disease. Clin Microbiol Rev 17:465-493, 2004.
14. Korn G.: Experimentelle untersuchungen zum virusnachweis im inkubationsstadium der maul-und klauenseuche und zu ihrer pathogenese. Arch Exp Veterinarmed 11:637-649, 1957.
15. McVicar JW, Graves JH, Sutmoller P.: Growth of foot-and-mouth disease virus in the bovine pharynx. In: Proceedings of the 74th Annual Meeting of the United States Animal Health Association, pp. 230-234. United States Animal Health Association, St. Joseph, MO, 1970.
16. Monaghan P., Gold S., Simpson J., Zhang Z., Weinreb PH, Violette SM, Alexandersen S., Jackson T.: The alpha(v)beta6 integrin receptor for foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle. J Gen Virol 86:2769-2780, 2005.
17. O'Donnell V., Pacheco JM, Gregg D., Baxt B.: Analysis of foot-and-mouth disease virus integrin receptor expression in tissues from naive and infected cattle. J Comp Pathol 141:98-112, 2009.
18. Pacheco JM, Arzt J., Rodriguez LL: Early events in the pathogenesis of foot-and-mouth disease in cattle after controlled aerosol exposure. Vet J 183:46-53, 2008.
19. Palmer MV, Thacker TC, Waters WR: Histology, immunohistochemistry and ultrastructure of the bovine palatine tonsil with special emphasis on reticular epithelium. Vet Immunol Immunopathol 127:277-285, 2009.
20. Prato Murphy ML, Forsyth MA, Belsham GJ, Salt JS: Localization of foot-and-mouth disease virus RNA by in situ hybridization within bovine tissues. Virus Res 62:67-76, 1999.
21. Seibold HR: A revised concept of the lingual lesions in cattle with foot-and-mouth disease. Am J Vet Res 24:1123-1130, 1963.
22. Sellers RF, Parker J.: Airborne excretion of foot-and-mouth disease virus. J Hyg (Lond) 67:671-677, 1969.
23. Stave JW, Card JL, Morgan DO: Analysis of foot-and-mouth disease virus type O1 Brugge neutralization epitopes using monoclonal antibodies. J Gen Virol 67:2083-2092, 1986.
24. Sutmoller P., McVicar JW: Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus. J Hyg (Lond) 77:235-243, 1976.
25. Swaney LM: A continuous bovine kidney cell line for routine assays of foot-and-mouth disease virus. Vet Microbiol 18:1-14, 1988.
26. Woodbury EL, Ilott MC, Brown CC, Salt JS: Optimization of an in situ hybridization technique for the detection of foot-and-mouth disease virus in bovine tissues using the digoxigenin system. J Virol Methods 51:89-93, 1995.
27. Yang M., Clavijo A., Li M., Hole K., Holland H., Wang H., Deng MY: Identification of a major antibody binding epitope in the non-structural protein 3D of foot-and-mouth disease virus in cattle and the development of a monoclonal antibody with diagnostic applications. J Immunol Methods 321:174-181, 2007.
28. Yilma T.: Morphogenesis of vesiculation in foot-and-mouth disease. Am J Vet Res 41:1537-1542, 1980.