The role of secreted frizzled-related protein 2 expression in prostate cancer

Histopathology

Volumn 59, Issue 6, 2011, Pages 1240-1248

  O'Hurley, Gillian ^a   Perry, Antoinette S ^b   O'Grady, Anthony ^a   Loftus, Barbara ^c   Smyth, Paul ^b   O'Leary, John J ^b   Sheils, Orla ^b   Fitzpatrick, John M ^d   Hewitt, Stephen M ^e   Lawler, Mark ^b   Kay, Elaine W ^a  

^a BEAUMONT HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c ADELAIDE AND MEATH HOSPITAL   (Ireland)

^d MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Immunohistochemistry; Prostate cancer; SFRP 2; Tissue microarrays; Wnt signalling

Indexed keywords

SECRETED FRIZZLED RELATED PROTEIN 2;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER MORPHOLOGY; CANCER RECURRENCE; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; TISSUE MICROARRAY;

ADULT; AGED; CARCINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84855916559     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.04073.x     Document Type: Article

References (16)

1. Verheyen EM, Gottardi CJ. Regulation of Wnt/beta-catenin signaling by protein kinases. Dev. Dyn. 2010; 239; 34-44.
2. Miller JR. The Wnts. Genome Biol. 2002; 3; reviews 3001.1-3001.15.
3. Pongracz JE, Stockley RA. Wnt signalling in lung development and diseases. Respir. Res. 2006; 7; 15.
4. Kawamoto K, Hirata H, Kikuno N, Tanaka Y, Nakagawa M, Dahiya R. DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines. Int. J. Cancer 2008; 123; 535-542.
5. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J. Cell Sci. 2008; 121; 737-746.
6. Emami KH, Corey E. When prostate cancer meets bone: control by wnts. Cancer Lett. 2007; 253; 170-179.
7. Polakis P. Wnt signaling and cancer. Genes Dev. 2000; 14; 1837-1851.
8. Suzuki H, Gabrielson E, Chen W et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat. Genet. 2002; 31; 141-149.
9. Zou H, Molina JR, Harrington JJ et al. Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Int. J. Cancer 2005; 116; 584-591.
10. Marsit CJ, Karagas MR, Andrew A et al. Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. Cancer Res. 2005; 65; 7081-7085.
11. Cheng YY, Yu J, Wong YP et al. Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br. J. Cancer 2007; 97; 895-901.
12. Nomoto S, Kinoshita T, Kato K et al. Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. Br. J. Cancer 2007; 97; 1260-1265.
13. Fukui T, Kondo M, Ito G et al. Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene 2005; 24; 6323-6327.
14. Veeck J, Noetzel E, Bektas N et al. Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancer. Mol. Cancer 2008; 7; 83.
15. Sokoloff MH, Yang XJ, Fumo M, Mhoon D, Brendler CB. Characterizing prostatic adenocarcinomas in men with a serum prostate specific antigen level of <4.0ng/mL. BJU Int. 2004; 93; 499-502.
16. Veltri RW, Marlow C, Khan MA, Miller MC, Epstein JI, Partin AW. Significant variations in nuclear structure occur between and within Gleason grading patterns 3, 4, and 5 determined by digital image analysis. Prostate 2007; 67; 1202-1210.