Endo-lysosome function in the retinal pigment epithelium in health and disease

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 723-729

  Lakkaraju, Aparna ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

A2E; Age Related Macular Degeneration; Apolipoprotein; Cholesterol; Late Endosome; Lipofuscin; Lysosome; Niemann Pick C1; Protein Lipid Trafficking; Retinal Pigment Epithelium

Indexed keywords

CHOLESTEROL; LIPID; LIPOFUSCIN; MEMBRANE PROTEIN;

CHOLESTEROL METABOLISM; CONFERENCE PAPER; ENDOCYTOSIS; ENDOSOME; HOMEOSTASIS; HUMAN; LIPID METABOLISM; LYSOSOME; MACROMOLECULE; MITOSIS; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT; RETINA MACULA AGE RELATED DEGENERATION; TIGHT JUNCTION; TRANS GOLGI NETWORK;

ENDOSOMES; HUMANS; LYSOSOMES; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM;

EID: 84855913894     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_92     Document Type: Conference Paper

References (30)

1. Anderson DH, Ozaki S, Nealon M et al (2001) Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: Implications for the process of drusen formation. Am J Ophthalmol 131:767-781 (Pubitemid 32522648)
2. Boesze-Battaglia K, Albert AD (1990) Cholesterol modulation of photoreceptor function in bovine retinal rod outer segments. J Biol Chem 265:20727-20730 (Pubitemid 120014069)
3. Bok D (1993) The retinal pigment epithelium: a versatile partner in vision. J Cell Sci Suppl 17:189-195 (Pubitemid 24041298)
4. Bok D (2005) Evidence for an infl ammatory process in age-related macular degeneration gains new support. Proc Natl Acad Sci USA 102:7053-7054 (Pubitemid 40696331)
5. Casserly I, Topol E (2004) Convergence of atherosclerosis and Alzheimer's disease: infl ammation, cholesterol, and misfolded proteins. Lancet 363:1139-1146 (Pubitemid 38452789)
6. Chen W, Stambolian D, Edwards AO et al (2010) Genetic variants near TIMP3 and high-density lipoprotein-associated loci infl uence susceptibility to age-related macular degeneration. Proc Natl Acad Sci USA 107:7401-7406
7. Chinchore Y, Mitra A, Dolph PJ (2009) Accumulation of Rhodopsin in Late Endosomes Triggers Photoreceptor Cell Degeneration. Plos Genetics 5: e1000377
8. Claudepierre T, Paques M, Simonutti M et al (2010) Lack of Niemann-Pick type C1 induces agerelated degeneration in the mouse retina. Mol Cell Neurosci 43:164-176
9. Curcio CA, Johnson M, Huang JD et al (2010) Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration. J Lipid Res 51:451-467
10. Feeney-Burns L, Eldred GE (1983) The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium. Trans Ophthalmol Soc UK 103 ( Pt 4):416-421 (Pubitemid 14099759)
11. Huang J, Feigenson GW (1999) A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers. Biophys J 76:2142-2157 (Pubitemid 29266367)
12. Klein R, Cruickshanks KJ, Nash SD et al (2010) The prevalence of age-related macular degeneration and associated risk factors. Arch Ophthalmol-Chic 128:750-758
13. Lakkaraju A, Rodriguez-Boulan E (2008) Itinerant exosomes: Emerging roles in cell and tissue polarity. Trends Cell Biol 18:199-209
14. Lakkaraju A, Finnemann SC, Rodriguez-Boulan E (2007) The lipofuscin fl uorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci USA 104:11026-11031 (Pubitemid 47175220)
15. Liu JP, Tang Y, Zhou SF et al (2010) Cholesterol involvement in the pathogenesis of neurodegenerative diseases. Mol Cell Neurosci 43:33-42
16. Midorikawa R, Yamamoto-Hino M, Awano W et al (2010) Autophagy-dependent rhodopsin degradation prevents retinal degeneration in drosophila. J Neurosci 30:10703-10719
17. Neale BM, Fagerness J, Reynolds R et al (2010) Genome-wide association study of advanced agerelated macular degeneration identifi es a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci USA 107:7395-7400
18. Nixon RA, Yang DS, Lee JH (2008) Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy 4:590-599
19. Nixon RA, Wegiel J, Kumar A et al (2005) Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol 64:113-122 (Pubitemid 40349309)
20. Phillips SE, Woodruff EA, 3rd, Liang P et al (2008) Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. J Neurosci 28:6569-6582
21. Rodriguez-Boulan E, Kreitzer G, Musch A (2005) Organization of vesicular traffi cking in epithelia. Nat Rev Mol Cell Biol 6:233-247 (Pubitemid 40314924)
22. Saftig P, Klumperman J (2009) Lysosome biogenesis and lysosomal membrane proteins: traffi cking meets function. Nat Rev Mol Cell Biol 10:623-635
23. Simons K, Gruenberg J (2000) Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends Cell Biol 10:459-462
24. Sparrow JR, Boulton M (2005) RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80:595-606 (Pubitemid 40602960)
25. Strauss O (2005) The retinal pigment epithelium in visual function. Physiol Rev 85:845-881 (Pubitemid 40885218)
26. van der Goot FG, Gruenberg J (2006) Intra-endosomal membrane traffi c. Trends Cell Biol 16: 514-521
27. van Meel E, Klumperman J (2008) Imaging and imagination: understanding the endo-lysosomal system. Histochem Cell Biol 129:253-266
28. Vitner EB, Platt FM, Futerman AH (2010) Common and uncommon pathogenic cascades in lysosomal storage diseases. J Biol Chem 285:20423-20427
29. Wenk MR (2005) The emerging field of lipidomics. Nat Rev Drug Discov 4:594-610 (Pubitemid 40975712)
30. Zareparsi S, Buraczynska M, Branham KE et al (2005) Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet 14:1449-1455 (Pubitemid 40834203)