In the nadr regulon, adhesins and diverse meningococcal functions are regulated in response to signals in human saliva

Journal of Bacteriology

Volumn 194, Issue 2, 2012, Pages 460-474

  Fagnocchi, Luca ^a   Pigozzi, Eva ^a   Scarlato, Vincenzo ^a,b   Delany, Isabel ^a  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYPHENYLACETIC ACID; ADHESIN; BACTERIAL DNA; BACTERIAL PROTEIN; NADA ADHESIN; NADR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; IN VITRO STUDY; MICROARRAY ANALYSIS; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULON; SALIVA; SIGNAL TRANSDUCTION;

ADHESINS, BACTERIAL; BACTERIAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MUTAGENESIS; NEISSERIA MENINGITIDIS; PHENYLACETATES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REGULON; REPRESSOR PROTEINS; SALIVA;

NEISSERIA MENINGITIDIS;

EID: 84855881498     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.06161-11     Document Type: Article

References (45)

1. Alvarez RA, Blaylock MW, Baseman JB. 2003. Surface localized glyceraldehyde-3-phosphate dehydrogenase of Mycoplasma genitalium binds mucin. Mol. Microbiol. 48:1417-1425.
2. Bentley SD, et al. 2007. Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18. PLoS Genet. 3:e23.
3. Capecchi B, et al. 2005. Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells. Mol. Microbiol. 55:687-698.
4. Cartwright KA, Stuart JM, Jones DM, Noah ND. 1987. The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamica. Epidemiol. Infect. 99:591-601.
5. Comanducci M, et al. 2002. NadA, a novel vaccine candidate of Neisseria meningitidis. J. Exp. Med. 195:1445-1454.
6. Deal CD, Krivan HC. 1990. Lacto- and ganglio-series glycolipids are adhesion receptors for Neisseria gonorrhoeae. J. Biol. Chem. 265: 12774-12777.
7. Delany I, Spohn G, Rappuoli R, Scarlato V. 2001. The Fur repressor controls transcription of iron-activated and -repressed genes in Helicobacter pylori. Mol. Microbiol. 42:1297-1309.
8. Egea L, et al. 2007. Role of secreted glyceraldehyde-3-phosphate dehydrogenase in the infection mechanism of enterohemorrhagic and enteropathogenic Escherichia coli: interaction of the extracellular enzyme with human plasminogen and fibrinogen. Int. J. Biochem. Cell Biol. 39: 1190-1203.
9. Ellison DW, Miller VL. 2006. Regulation of virulence by members of the MarR/SlyA family. Curr. Opin. Microbiol. 9:153-159.
10. Fantappiè L, et al. 2011. A novel Hfq-dependent sRNA that is under FNR control and is synthesized in oxygen limitation in Neisseria meningitidis. Mol. Microbiol. 80:507-523.
11. Giuliani MM, et al. 2006. A universal vaccine for serogroup B meningococcus. Proc. Natl. Acad. Sci. U. S. A. 103:10834-10839.
12. Gozalbo D, et al. 1998. The cell wall-associated glyceraldehyde-3- phosphate dehydrogenase of Candida albicans is also a fibronectin and laminin binding protein. Infect. Immun. 66:2052-2059.
13. Grifantini R, et al. 2002. Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat. Biotechnol. 20:914-921.
14. Hanahan D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
15. Ieva R, et al. 2005. CrgA is an inducible LysR-type regulator of Neisseria meningitidis, acting both as a repressor and as an activator of gene transcription. J. Bacteriol. 187:3421-3430.
16. Ieva R, et al. 2008. OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms. Mol. Microbiol. 70:1152-1165.
17. Kinoshita H, et al. 2008. Cell surface Lactobacillus plantarum LA 318 glyceraldehyde-3-phosphate dehydrogenase (GAPDH) adheres to human colonic mucin. J. Appl. Microbiol. 104:1667-1674.
18. Lee EH, Hill SA, Napier R, Shafer WM. 2006. Integration host factor is required for FarR repression of the farAB-encoded efflux pump of Neisseria gonorrhoeae. Mol. Microbiol. 60:1381-1400.
19. Lee EH, Rouquette-Loughlin C, Folster JP, Shafer WM. 2003. FarR regulates the farAB-encoded efflux pump of Neisseria gonorrhoeae via an MtrR regulatory mechanism. J. Bacteriol. 185:7145-7152.
20. Martin P, Makepeace K, Hill SA, Hood DW, Moxon ER. 2005. Microsatellite instability regulates transcription factor binding and gene expression. Proc. Natl. Acad. Sci. U. S. A. 102:3800-3804.
21. Martin P, et al. 2003. Experimentally revised repertoire of putative contingency loci in Neisseria meningitidis strain MC58: evidence for a novel mechanism of phase variation. Mol. Microbiol. 50:245-257.
22. Maxam AM, Gilbert W. 1977. A new method for sequencing DNA. Proc. Natl. Acad. Sci. U. S. A. 74:560-564.
23. Metruccio MM, et al. 2009. A novel phase variation mechanism in the meningococcus driven by a ligand-responsive repressor and differential spacing of distal promoter elements. PLoS Pathog. 5:e1000710.
24. Modun B, Morrissey J, Williams P. 2000. The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions. Trends Microbiol. 8:231-237.
25. Naumann M, Rudel T, Meyer TF. 1999. Host cell interactions and signalling with Neisseria gonorrhoeae. Curr. Opin. Microbiol. 2:62-70.
26. Nichols CE, et al. 2009. The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65:204-209.
27. Pancholi V, Fischetti VA. 1992. A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity. J. Exp. Med. 176:415-426.
28. Paruchuri DK, Seifert HS, Ajioka RS, Karlsson KA, So M. 1990. Identification and characterization of a Neisseria gonorrhoeae gene encoding a glycolipid-binding adhesin. Proc. Natl. Acad. Sci. U. S. A. 87:333-337.
29. Pizza M, et al. 2000. Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing. Science 287: 1816-1820.
30. Providenti MA, Wyndham RC. 2001. Identification and functional characterization of CbaR, a MarR-like modulator of the cbaABC-encoded chlorobenzoate catabolism pathway. Appl. Environ. Microbiol. 67: 3530-3541.
31. Rouquette-Loughlin CE, Balthazar JT, Hill SA, Shafer WM. 2004. Modulation of the mtrCDE-encoded efflux pump gene complex of Neisseria meningitidis due to a Correia element insertion sequence. Mol. Microbiol. 54:731-741.
32. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
33. Schielke S, et al. 2009. Expression of the meningococcal adhesin NadA is controlled by a transcriptional regulator of the MarR-family. Mol. Microbiol. 72:1054-1067.
34. Schielke S, et al. 2010. The transcriptional repressor FarR is not involved in meningococcal fatty acid resistance mediated by the FarAB efflux pump and dependent on lipopolysaccharide structure. Appl. Environ. Microbiol. 76:3160-3169.
35. Schielke S, et al. 2011. Characterization of FarR as a highly specialized, growth phase-dependent transcriptional regulator in Neisseria meningitidis. Int. J. Med. Microbiol. 301:325-333.
36. Shelburne SA, III, et al. 2008. Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. Mol. Microbiol. 69:436-452.
37. Shelburne SA, III, et al. 2006. Maltodextrin utilization plays a key role in the ability of group A Streptococcus to colonize the oropharynx. Infect. Immun. 74:4605-4614.
38. Siddique A, Buisine N, Chalmers R. 2011. The transposon-like Correia elements encode numerous strong promoters and provide a potential new mechanism for phase variation in the meningococcus. PLoS Genet. 7:e1001277.
39. Stephens DS. 1999. Uncloaking the meningococcus: dynamics of carriage and disease. Lancet 353:941-942.
40. Stromberg N, et al. 1988. Identification of carbohydrate structures that are possible receptors for Neisseria gonorrhoeae. Proc. Natl. Acad. Sci. U. S. A. 85:4902-4906.
41. Studier FW, Moffatt BA. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189: 113-130.
42. Swinger KK, Rice PA. 2004. IHF and HU: flexible architects of bent DNA. Curr. Opin. Struct. Biol. 14:28-35.
43. Takahama U, Oniki T, Murata H. 2002. The presence of 4-hydroxyphenylacetic acid inhumansaliva and the possibility of its nitration by salivary nitrite in the stomach. FEBS Lett. 518:116-118.
44. Tunio SA, Oldfield NJ, Ala'Aldeen DA, Wooldridge KG, Turner DP. 2010. The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells. BMC Microbiol. 10:280.
45. Wilkinson SP, Grove A. 2006. Ligand-responsive transcriptional regulation by members of the MarR family of winged helix proteins. Curr. Issues Mol. Biol. 8:51-62.