Serendipity strikes again: Scopolamine as an antidepressant agent in bipolar depressed patients

Current Psychiatry Reports

Volumn 13, Issue 6, 2011, Pages 443-445

  Janowsky, David S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adrenergic cholinergic balance hypothesis; Antidepressant; Bipolar disorder; Depression; Scopolamine

Indexed keywords

ACETYLCHOLINE; BETA ENDORPHIN; CHOLINESTERASE INHIBITOR; CORTICOTROPIN; PLACEBO; SCOPOLAMINE; SCOPOLAMINE BROMIDE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; ANTIDEPRESSANT AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT;

ADRENERGIC SYSTEM; BIPOLAR DEPRESSION; CHOLINERGIC SYSTEM; CLINICAL TRIAL (TOPIC); CORTICOTROPIN BLOOD LEVEL; DEPRESSION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESEARCH; HAMILTON ANXIETY SCALE; HUMAN; MAJOR DEPRESSION; MANIA; MONTGOMERY ASBERG DEPRESSION RATING SCALE; OUTCOME ASSESSMENT; PROTEIN BLOOD LEVEL; PSYCHOPHARMACOLOGY; REM SLEEP; REVIEW; YOUNG MANIA RATING SCALE; ARTICLE; BIPOLAR DISORDER;

ANTIDEPRESSIVE AGENTS; BIPOLAR DISORDER; HUMANS; MUSCARINIC ANTAGONISTS; SCOPOLAMINE HYDROBROMIDE;

EID: 84855872975     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-011-0239-6     Document Type: Review

References (5)

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3. Drevets WC, Furey ML. Replication of scopolamine's antidepressant efficacy in major depressive disorder: A randomized, placebocontrolled clinical trial. Biol Psychiatry. 2010;67(5):432-8.
4. Furey ML, Khanna A, Hoffman EM, Drevets WC. Scopolamine produces larger antidepressant effects and antianxiety effects in women than in men. Neuropsychopharmacology. 2010;35(12):2479-88.
5. Frankel E, Drevets W, Luckenbaugh D, Speer A, Nugent A, Zarate C, Furey M. 9th International Conference on Bipolar Disorder: Poster P58, Presented June 9, 2011, Pittsburgh, PA.