Lung histopathological findings in fatal pandemic influenza A (H1N1)

Medicina Intensiva

Volumn 36, Issue 1, 2012, Pages 24-31

  Nin, N ^a,b   Sanchez Rodriguez C ^a,b   Ver, L S ^b,c   Cardinal, P ^d   Ferruelo, A ^a,b   Soto, L ^e   Deicas, A ^d   Campos, N ^f   Rocha, O ^g   Ceraso, D H ^h   El Assar, M ^a,b   Ortin J ^b,c   Fernandez Segoviano P ^a,b   Esteban, A ^a,b   Lorente, J A ^a,b  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d Sanatorio Casmu   (Uruguay)

^e Instituto Nacional de Tórax   (Chile)

^f Hospital Regional de Salto   (Uruguay)

^g Sanatorio GREMEDA   (Uruguay)

^h HOSPITAL JUAN A FERNÁNDEZ   (Argentina)

Author keywords

ARDS; H1N1; Lung pathology; Mechanical ventilation

Indexed keywords

3 NITROTYROSINE; ANTIVIRUS AGENT; DIHYDROETHYDIUM; INDUCIBLE NITRIC OXIDE SYNTHASE; NUCLEOPROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

2009 H1N1 INFLUENZA; ADOLESCENT; ADULT; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS REACTION; DIFFUSE ALVEOLAR DAMAGE; FEMALE; HISTOPATHOLOGY; HOSPITALIZATION; HUMAN; HUMAN TISSUE; HYPOXEMIA; IMMUNOFLUORESCENCE TEST; INTENSIVE CARE UNIT; LENGTH OF STAY; LUNG ALVEOLUS CELL; LUNG DISEASE; LUNG FIBROSIS; MACROPHAGE; MALE; MORPHOLOGY; NITRATION; NITROOXIDATIVE STRESS; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE PREPARATION;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; CONSENSUS SEQUENCE; CROSS REACTIONS; FATAL OUTCOME; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; LUNG; MACROPHAGES; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PNEUMOCYTES; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA-BINDING PROTEINS; TYROSINE; VIRAL CORE PROTEINS; YOUNG ADULT;

EID: 84855850765     PISSN: 02105691     EISSN: 15786749     Source Type: Journal    
DOI: 10.1016/j.medin.2011.10.005     Document Type: Article

References (23)

1. Perez-Padilla R., de la Rosa-Zamboni D., Ponce de Leon S., Hernandez M., Quiñones-Falconi F., Bautista E., et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009, 361:680-689.
2. González-Vélez A.E., Díaz-Agero-Pérez C., Robustillo-Rodela A., Cornejo-Gutiérrez A.M., Pita-López M.J., Oliva-Iñiguez L., et al. Factors associated to admission to intensive care in patients hospitalized due to pandemic Influenza A/H1N1 2009. Med Intensiva 2011, 35:463-469.
3. Rello J., Rodríguez A., Ibañez P., Socias L., Cebrian J., Marques A., et al. H1N1 SEMICYUC Working Group Intensive care adult patients with severe respiratory failure caused by influenza A (H1N1) in Spain. Crit Care 2009, 13:R148.
4. Rodríguez A., Martin-Loeches I., Bonastre J., Olaechea P., Alvarez-Lerma F., Zaragoza R., et al. SEMICYUC-CIBERES-REIPI working group. First influenza season after the 2009 pandemic influenza: report of the first 300 ICU admissions in Spain. Med Intensiva 2011, 35:208-216.
5. Rodríguez A., Socías L., Guerrero J.E., Figueira J.C., González N., Maraví-Poma E., et al. Pandemic influenza A in the ICU: experience in Spain and Latin America GETGAG/SEMICYUC/(Spanish Work Group on Severe Pandemic Influenza A/SEMICYUC). Med Intensiva 2010, 34:87-94.
6. Domínguez-Cherit G., Lapinsky S.E., Macias A.E. Critically ill patients with 2009 influenza A (H1N1) in Mexico. JAMA 2009, 302:E1-E8.
7. Mauad T., Hajjar L.A., Callegari G.D., da Silva L.F., Schout D., Galas F.R., et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med 2010, 181:72-79.
8. Mukhopadhyay S., Philip A.T., Stoppacher R. Pathologic findings in novel influenza A (H1N1) virus (" swine flu" ) infection: contrasting clinical manifestations and lung pathology in two fatal cases. Am J Clin Pathol 2010, 133:380-387.
9. Soto-Abraham M.V., Soriano-Rosas J., Díaz-Quiñónez A., Silva-Pereyra J., Vazquez-Hernandez P., Torres-López O., et al. Pathological changes associated with the 2009 H1N1 virus. N Engl J Med 2009, 361:2001-2003.
10. Taubenberger J.K., Morens D.M. The pathology of influenza virus infections. Annu Rev Pathol 2008, 3:499-522.
11. Gill J.R., Sheng Z.M., Ely S.F., Guinee D.G., Beasley M.B., Suh J., et al. Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Arch Pathol Lab Med 2010, 134:235-243.
12. Gole M.D., Souza J.M., Choi I., Hertkorn C., Malcolm S., Foust R.F., 3rd, et al. Plasma proteins modified by tyrosine nitration in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2000, 278:961-967.
13. Lamb N.J., Gutteridge J.M., Baker C., Evans T.W., Quinlan G.J. Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination. Crit Care Med 1999, 27:1738-1744.
14. Martínez-Caro L., Lorente J.A., Marín-Corral J., Sánchez-Rodríguez C., Sánchez-Ferrer A., Nin N., et al. Role of free radicals in vascular dysfunction induced by high tidal volume ventilation. Intensive Care Med 2009, 35:1110-1119.
15. Peiró C., Lafuente N., Matesanz N., Cercas E., Llergo J.L., Vallejo S., et al. High glucose induces cell death of cultured human aortic smooth muscle cells through the formation of hydrogen peroxide. Br J Pharmacol 2001, 133(August):967-974.
16. Peiro C., Matesanz N., Nevado J., Lafuente N., Cercas E., Azcutia V., et al. Glycosylated human oxyhaemoglobin activates nuclear factor-kappaB and activator protein-1 in cultured human aortic smooth muscle. Br J Pharmacol 2003, 140(October):681-690.
17. Nakajima M., Kawanami O., Jin E.J., Ghazizadeh M., Honda M., Asano G., et al. Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways. Pathol Int 1998, 48:944-953.
18. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 1999, 41:95-98.
19. Jorba N., Juarez S., Torreira E., Gastaminza P., Zamarreño N., Albar J.P., et al. Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics 2008, 8:2077-2088.
20. Bernard G.R., Artigas A., Brigham K.L., Carlet J., Falke K., Hudson L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824.
21. Katzenstein A.L., Myers J.L. Nonspecific interstitial pneumonia and the other idiopathic interstitial pneumonias: classification and diagnostic criteria. Am J Surg Pathol 2000, 24:1-3.
22. Bruder D., Srikiatkhachorn A., Enelow R.L. Cellular immunity and lung injury in respiratory virus infection. Viral Immunol 2006, 19:147-155.
23. Wong J.P., Christopher M.E., Viswanathan S., Karpoff N., Dai X., Das D., et al. Activation of toll like receptor signaling pathway for protection against influenza virus infection. Vaccine 2009, 27:3481-3483.