Genetic association and gene-gene interaction analyses in African American dialysis patients with nondiabetic nephropathy

American Journal of Kidney Diseases

Volumn 59, Issue 2, 2012, Pages 210-221

  Bostrom, Meredith A ^a   Kao, W H Linda ^b   Li, Man ^b   Abboud, Hanna E ^c   Adler, Sharon G ^d   Iyengar, Sudha K ^e   Kimmel, Paul L ^f   Hanson, Robert L ^f   Nicholas, Susanne B ^g   Rasooly, Rebekah S ^f   Sedor, John R ^e   Coresh, Josef ^b   Kohn, Orly F ^h   Leehey, David J ⁱ   Thornley Brown, Denyse ^j   Bottinger, Erwin P ^k   Lipkowitz, Michael S ^l   Meoni, Lucy A ^b   Klag, Michael J ^b   Lu, Lingyi ^a   Hicks, Pamela J ^a   Langefeld, Carl D ^a   Parekh, Rulan S ^b,m   Bowden, Donald W ^a   Freedman, Barry I ^a   more..

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CHICAGO   (United States)

ⁱ LOYOLA UNIVERSITY CHICAGO   (United States)

^j UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^l GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

African American; APOL1; CFH; end stage renal disease; Family Investigation of Nephropathy and Diabetes (FIND); focal segmental glomerulosclerosis (FSGS); hypertension

Indexed keywords

APOLIPOPROTEIN A1;

ADULT; AFRICAN AMERICAN; AGE; ARTICLE; CHROMOSOME 22; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENDER; GENE INTERACTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HEMODIALYSIS PATIENT; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; AGED; APOLIPOPROTEINS; CASE-CONTROL STUDIES; EPISTASIS, GENETIC; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INCIDENCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY DISEASES; LIPOPROTEINS, HDL; MALE; MEMBRANE PROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RENAL DIALYSIS;

EID: 84855849622     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2011.09.020     Document Type: Article

References (33)

1. US Renal Data System USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States 2008 National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD http://www.usrds.org 2009 Accessed December 22, 2010
2. B.I. Freedman, B.J. Spray, A.B. Tuttle et al. The familial risk of end-stage renal disease in African Americans Am J Kidney Dis 21 4 1993 387 393 (Pubitemid 23132903)
3. B.I. Freedman, C.D. Langefeld, S.S. Rich et al. A genome scan for ESRD in black families enriched for nondiabetic nephropathy J Am Soc Nephrol 15 10 2004 2719 2727 (Pubitemid 41103379)
4. J.B. Kopp, M.W. Smith, G.W. Nelson et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis Nat Genet 40 10 2008 1175 1184
5. W.H. Kao, M.J. Klag, L.A. Meoni et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans Nat Genet 40 10 2008 1185 1192
6. B.I. Freedman, P.J. Hicks, M.A. Bostrom et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans Kidney Int 75 7 2009 736 745
7. G. Genovese, D.J. Friedman, M.D. Ross et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans Science 329 5993 2010 841 845
8. S. Tzur, S. Rosset, R. Shemer et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene Hum Genet 128 3 2010 345 350
9. M.A. Bostrom, L. Lu, J. Chou et al. Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA Hum Genet 128 2 2010 195 204
10. H.R. Rubin, M. Jenckes, N.E. Fink et al. Patient's view of dialysis care: development of a taxonomy and rating of importance of different aspects of care CHOICE Study. Choices for Healthy Outcomes in Caring for ESRD Am J Kidney Dis 30 6 1997 793 801 (Pubitemid 27524342)
11. J.M. Kaplan, S.H. Kim, K.N. North et al. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis Nat Genet 24 3 2000 251 256 (Pubitemid 30132192)
12. M. Kestila, U. Lenkkeri, M. Mannikko et al. Positionally cloned gene for a novel glomerular proteinnephrinis mutated in congenital nephrotic syndrome Mol Cell 1 4 1998 575 582 (Pubitemid 128374693)
13. N. Boute, O. Gribouval, S. Roselli et al. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome Nat Genet 24 4 2000 349 354 (Pubitemid 30187431)
14. M.P. Winn, P.J. Conlon, K.L. Lynn et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis Science 308 5729 2005 1801 1804 (Pubitemid 40848011)
15. T.C. Hart, M.C. Gorry, P.S. Hart et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy J Med Genet 39 12 2002 882 892 (Pubitemid 36009149)
16. J.C. Chambers, W. Zhang, G.M. Lord et al. Genetic loci influencing kidney function and chronic kidney disease Nat Genet 42 5 2010 373 375
17. M. Kamiyama, M. Kobayashi, S. Araki et al. Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy Hum Genet 122 3-4 2007 397 407 (Pubitemid 47616548)
18. K.L. Keene, J.C. Mychaleckyj, T.S. Leak et al. Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease Hum Genet 124 2 2008 147 154
19. J.B. Harley, M.E. Arcon-Riquelme, L.A. Criswell et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet 40 2 2008 204 210 (Pubitemid 351171405)
20. X. Gao, J. Starmer, E.R. Martin A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms Genet Epidemiol 32 4 2008 361 369 (Pubitemid 351656307)
21. M.E. Talbert, C.D. Langefeld, J.T. Ziegler et al. INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study Obesity (Silver Spring) 17 8 2009 1554 1562
22. D. Reich, N. Patterson, V. Ramesh et al. Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels Am J Hum Genet 80 4 2007 716 726 (Pubitemid 46564408)
23. D.P. Gale, E.G. de Jorge, H.T. Cook et al. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis Lancet 376 9743 2010 794 801
24. G. Mollet, J. Ratelade, O. Boyer et al. Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome J Am Soc Nephrol 20 10 2009 2181 2189
25. B.G. Hinkes, B. Mucha, C.N. Vlangos et al. Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2) Pediatrics 119 4 2007 e907 e919
26. A.C. Pereira, A.B. Pereira, G.F. Mota et al. NPHS2 R229Q functional variant is associated with microalbuminuria in the general population Kidney Int 65 3 2004 1026 1030 (Pubitemid 38258280)
27. B.I. Freedman, J.B. Kopp, C.D. Langefeld et al. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans J Am Soc Nephrol 21 9 2010 1422 1426
28. A.G. Gharavi, K. Kiryluk, M. Choi et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy Nat Genet 43 4 2011 321 327
29. T.K. Maga, C.J. Nishimura, A.E. Weaver et al. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome Hum Mutat 31 6 2010 E1445 E1460
30. L. Ying, Y. Katz, M. Schlesinger et al. Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome Am J Hum Genet 65 6 1999 1538 1546 (Pubitemid 30468666)
31. C. Xing, T.A. Sivakumaran, J.J. Wang et al. Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study Genes Immun 9 3 2008 231 239 (Pubitemid 351584189)
32. S. Prakash, N. Papeta, R. Sterken et al. Identification of the nephropathy-susceptibility locus HIVAN4 J Am Soc Nephrol 22 8 2011 1497 1504
33. N. Papeta, K.T. Chan, S. Prakash et al. Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression J Clin Invest 119 5 2009 1178 1188