Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs

Journal of Controlled Release

Volumn 157, Issue 1, 2012, Pages 112-117

  Baba, Miyuki ^a,b   Matsumoto, Yu ^a,b   Kashio, Akinori ^a   Cabral, Horacio ^b   Nishiyama, Nobuhiro ^b   Kataoka, Kazunori ^b   Yamasoba, Tatsuya ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Auditory brainstem response; Cisplatin; Guinea pig; Hair cell; Ototoxicity; Polymeric micelle

Indexed keywords

AUDITORY BRAINSTEM RESPONSE; CIS-PLATIN; GUINEA PIGS; HAIR CELLS; OTOTOXICITY; POLYMERIC MICELLE;

BRAIN; CELLS; CHEMOTHERAPY; FLUORESCENCE SPECTROSCOPY; MAMMALS; MICELLES; MICELLIZATION; PLATINUM; PLATINUM COMPOUNDS;

POLYMERS;

CISPLATIN; MACROGOL; NANOCARRIER; NC 6004; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; AUDITORY THRESHOLD SHIFT; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; CORTI ORGAN; DOSE RESPONSE; DRUG EFFICACY; DRUG MEGADOSE; EVOKED BRAIN STEM AUDITORY RESPONSE; GUINEA PIG; HAIR CELL; MALE; MICELLIZATION; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SINGLE DRUG DOSE; SURVIVAL RATE; SYNCHROTRON RADIATION; TREATMENT OUTCOME; X RAY FLUORESCENCE;

ANIMALS; CISPLATIN; DRUG CARRIERS; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GUINEA PIGS; HAIR CELLS, AUDITORY; MALE; MICELLES; NANOCAPSULES; ORGANOPLATINUM COMPOUNDS; POLYGLUTAMIC ACID;

EID: 84855827702     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.07.026     Document Type: Article

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