MT1-MMP modulates the mechanosensitivity of osteocytes

Biochemical and Biophysical Research Communications

Volumn 417, Issue 2, 2012, Pages 824-829

  Kulkarni, Rishikesh N ^a   Bakker, Astrid D ^a   Gruber, Elisabeth V ^a,b   Chae, Thomas D ^a,c   Veldkamp, Joris B B ^a   Klein Nulend, Jenneke ^a   Everts, Vincent ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c New York Presbyterian Hospital   (United States)

Author keywords

Mechanical loading; Mechanosensitivity; MT1 MMP; Osteocytes; Pulsating fluid flow

Indexed keywords

CYCLOOXYGENASE 2; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; NITRIC OXIDE; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOMECHANICS; CELL ADHESION; CELL SIZE; CONTROLLED STUDY; DOWN REGULATION; ENZYME SYNTHESIS; GENE EXPRESSION; MECHANICAL STIMULATION; METAPHYSIS; MOUSE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; FOCAL ADHESIONS; GENE KNOCKDOWN TECHNIQUES; MATRIX METALLOPROTEINASE 14; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, MUTANT STRAINS; OSTEOCYTES; PULSATILE FLOW; RNA, SMALL INTERFERING; STRESS, MECHANICAL;

MUS;

EID: 84855822532     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.045     Document Type: Article

References (28)

1. Cowin S.C., Moss-Salentijn L., Moss M.L. Candidates for the mechanosensory system in bone. J. Biomech. Eng. 1991, 113:191-197.
2. Burger E.H., Klein-Nulend J. Responses of bone cells to biomechanical forces in vitro. Adv. Dent. Res. 1999, 13:93-98.
3. Kamioka H., Honjo T., Takano-Yamamoto T. A three dimensional-distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. Bone 2001, 28:145-149.
4. Sugawara Y., Kamioka H., Honjo T., et al. Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy. Bone 2005, 36:877-883.
5. Nicolella D.P., Moravits D.E., Gale A.M., et al. Osteocyte lacunae tissue strain in cortical bone. J. Biomech. 2006, 39:1735-1743.
6. Klein-Nulend J., van der Plas A., Semeins C.M., et al. Sensitivity of osteocytes to mechanical stress in vitro. FASEB J. 1995, 9:441-445.
7. Holmbeck K., Bianco P., Caterina J., et al. MT1-MMP deficient mice develop dwarfism, osteopenia, arthritis and connective tissue disease due to inadequate collagen turnover. Cell 1999, 99:81-92.
8. Murphy G., Knäuper V., Atkinson S., et al. Matrix metalloproteinases in arthritic disease. Arthritic Res. 2002, 4:S39-S49.
9. Kajita M., Itoh Y., Chiba T., et al. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J. Cell Biol. 2001, 153:893-904.
10. Hughes D.E., Salter D.M., Simpson R. CD44 expression in human bone: a novel marker of osteocytic differentiation. J. Bone Miner. Res. 1994, 9:39-44.
11. Holmbeck K., Bianco P., Pidoux I., et al. The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone. J. Cell Science 2005, 118:147-156.
12. Gonzalo P., Guadamillas M.C., Hernandez-Riquer M.V., et al. MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling. Dev. Cell 2010, 18:77-89.
13. Young S.R.L., Gerard-O'Riley R., Kim J.B., Pavalko F.M. Focal adhesion kinase is important for fluid shear stress-induced mechanotransduction in osteoblasts. J. Bone Min. Res. 2009, 24:411-424.
14. Santos A., Bakker A.D., Zandieh-Doulabi B., et al. Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase. Biochem. Biophys. Res. Commun. 2010, 391:364-369.
15. Eisenach P.A., Roghi C., Fogarasi M., et al. MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J. Cell Sci. 2010, 123:4182-4193.
16. Turner C.H., Pavalko F.M. Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation. J. Orthop. Sci. 1998, 3:346-355.
17. Kato Y., Windle J.J., Koop B.A., et al. Establishment of an osteocyte-like cell line, MLO-Y4. J. Bone Miner. Res. 1997, 12:2014-2023.
18. Bakker A.D., Soejima K., Klein-Nulend J., Burger E.H. The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent. J. Biomech. 2001, 34:671-677.
19. Bacabac R.G., Smit T.H., Cowin S.C., et al. Dynamic shear stress in parallel-plate flow chambers. J. Biomech. 2005, 38:159-167.
20. Kulkarni R.N., Bakker A.D., Everts V., Klein-Nulend J. Inhibition of osteoclastogenesis by mechanically loaded osteocytes: Involvement of MEPE. Calcif. Tissue Int. 2010, 87:461-468.
21. Geiger B., Bershadsky A., Pankov R., Yamada K.M. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2001, 2:793-805.
22. Chen C.S., Tan J., Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annu. Rev. Biomed. Eng. 2004, 6:275-302.
23. Takino T., Watanabe Y., Matsui M., et al. Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration. Exp. Cell Res. 2006, 312:1381-1389.
24. Robling A.G., Hinant F.M., Burr D.B., Turner C.H. Improved bone structure and strength after long-term mechanical loading is greatest if loading is separated into short bouts. J. Bone Miner. Res. 2002, 17:1545-1554.
25. Dallas S.L. Dynamics of assembly and reorganization of extracellular matrix proteins. Curr. Top. Dev. Biol. 2006, 75:1-24.
26. Tan S.D., Bakker A.D., Semeins C.M., et al. Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide. Biochem. Biophys. Res. Commun. 2008, 369:1150-1154.
27. Vatsa A., Breuls R.G., Semeins C.M., et al. Osteocyte morphology in fibula and calvaria - is there a role for mechanosensing. Bone 2008, 43:452-458.
28. H. Britz, Y. Carter, J. Jokihaara, et al., Prolonged Unloading in Growing Rats Reduces Cortical Osteocyte Lacunar Density and Volume in the Distal Tibia, Transactions of the 2011 Annual Meeting of the American Society for Bone and Mineral Research, 2011 (abstract number su0073).