Dietary free glutamate prevents diarrhoea during intra-gastric tube feeding in a rat model

British Journal of Nutrition

Volumn 107, Issue 1, 2012, Pages 20-23

  Somekawa, Shinji ^a   Hayashi, Naoki ^a   Niijima, Akira ^b   Uneyama, Hisayuki ^a   Torii, Kunio ^a  

^a AJINOMOTO CO INC   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Diarrhoea; Enteral nutrition; l Glutamate; Vagal nerve

Indexed keywords

GLUTAMATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; EFFERENT NERVE; ENTERIC FEEDING; FECES ANALYSIS; MALE; NONHUMAN; PROTEIN DIET; RAT; TUBE FEEDING; VAGUS NERVE;

AFFERENT PATHWAYS; ANIMALS; DIARRHEA; DIETARY PROTEINS; DISEASE MODELS, ANIMAL; ENTERAL NUTRITION; FECES; FOOD, FORMULATED; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; SODIUM GLUTAMATE; STOMACH; TIME FACTORS; VAGUS NERVE;

RATTUS;

EID: 84855820455     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511002674     Document Type: Article

References (28)

1. Vasilevskaia LS, Rymshina MV & Shlygin GK (1993) Effect of glutamate and combined with inosine monophosphate on gastric secretion. Vopr Pitan 3, 29-33.
2. Ohara I, Otsuka S & Yugari Y (1988) Cephalic phase response of pancreatic exocrine secretion in conscious dogs. Am J Physiol 254, G424-G428.
3. Spielman AI (1990) Interaction of saliva and taste. J Dent Res 69, 838-843.
4. Raybould HE (2002) Visceral perception: sensory transduc-tion in visceral afferents and nutrients. Gut 51, Suppl. 1, i11-i14. (Pubitemid 34717712)
5. Graham TE, Sgro V, Friars D, et al. (2000) Glutamate inges-tion: the plasma and muscle free amino acid pools of resting humans. Am J Physiol Endocrinol Metab 278, E83-E89. (Pubitemid 30101923)
6. Zolotarev V, Khropycheva R, Uneyama H, et al. (2009) Effect of free dietary glutamate on gastric secretion in dogs. Ann N Y Acad Sci 1170, 87-90.
7. Uneyama H, Niijima A, San Gabriel A, et al. (2006) Luminal amino acid sensing in the rat gastric mucosa. Am J Physiol Gastrointest Liver Physiol 291, G1163-G1170. (Pubitemid 44904171)
8. Cervero F (1994) Sensory innervation of the viscera: peripheral basis of visceral pain. Physiol Rev 74, 95-138. (Pubitemid 24045675)
9. Li Y, Hao Y, Zhu J, et al. (2000) Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats. Gastroenterology 118, 1197-1207. (Pubitemid 30346997)
10. Schwartz GJ & Moran TH (1998) Duodenal nutrient exposure elicits nutrient-specific gut motility and vagal afferent signals in rat. Am J Physiol 274 (5 Pt 2), R1236-R1242.
11. Uneyama H, San Gabriel A, Kawai M, et al. (2008) Physiological role of dietary free glutamate in the food digestion. Asia Pac J Clin Nutr 17, Suppl. 1, 372-375.
12. Lefron J (2002) Management of common gastrointestinal complication in tube-fed patients. Support Line 24, 19-25.
13. Loudon JL (1977) Symposium on diarrhea. 5. Postoperative diarrhea. Can Med Assoc J 116, 748-750.
14. Kitamura A, Sato W, Uneyama H, et al. (2011) Effects of intra-gastric infusion of inosine monophosphate and L-glutamate on vagal gastric afferent activity and subsequent autonomic reflexes. J Physiol Sci 61, 65-71.
15. Giacometti T (1979) Sensory and dietary aspects of gluta-mate. In Glutamic Acid: Advances in Biochemistry and Physiology, pp. 25-34 [LJ Filter Jr, S Garattini, MR Kare and WA Raynolds, editors]. New York, NY: Raven.
16. Yamaguchi S & Takahashi C (1984) Hedonic functions of monosodium glutamate and four basic taste substances used at various concentration levels in single and complex systems. Agric Biol Chem 48, 1077-1081.
17. Trifan OC, Durham WF, Salazar VS, et al. (2002) Cyclo-oxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11. Cancer Res 62, 5778-5784. (Pubitemid 35204735)
18. Takasuna K, Hagiwara T, Watanabe K, et al. (2006) Optimal antidiarrhea treatment for antitumor agent irinotecan hydrochloride (CPT-11)-induced delayed diarrhea. Cancer Chemother Pharmacol 58, 494-503. (Pubitemid 43999798)
19. Xue H, Sawyer MB, Field CJ, et al. (2007) Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor. Clin Cancer Res 13, 7146-7154. (Pubitemid 350276901)
20. Zhang XX, Pan WS, Gan L, et al. (2008) Effects of breast cancer resistance protein inhibitors and pharmaceutical excipients on decreasing gastrointestinal toxicity of campto-thecin analogs. Acta Pharmacol Sin 29, 1391-1398.
21. Niijima A, Torii K & Uneyama H (2005) Role played by vagal chemical sensors in the hepato-portal region and duodeno-intestinal canal: an electrophysiological study. Chem Senses 30, Suppl. 1, i178-i179.
22. Toyomasu Y, Mochiki E, Yanai M, et al. (2010) Intragastric monosodium L-glutamate stimulates motility of upper gut via vagus nerve in conscious dogs. Am J Physiol Regul Integr Comp Physiol 298, R1125-R1135.
23. Zai H, Kusano M, Hosaka H, et al. (2009) Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying. Am J Clin Nutr 89, 431-435.
24. George JD & Magowan J (1971) Diarrhea after total and selective vagotomy. Am J Dig Dis 16, 635-640.
25. Boutry C, Bos C, Matsumoto H, et al. (2011) Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats. Front Biosci (Elite Ed) 3, 279-290.
26. Reeds PJ, Burrin DG, Jahoor F, et al. (1996) Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. Am J Physiol 270 (3 Pt 1), E413-E418.
27. Reeds PJ, Burrin DG & Stoll B (2000) Intestinal glutamate metabolism. J Nutr 130, Suppl. 4S, 978S-982S. (Pubitemid 30173628)
28. Zhan Z, Ou D, Piao X, et al. (2008) Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs. J Nutr 138, 1304-1309. (Pubitemid 351930994)