Emergence of novel equine arteritis virus (EAV) variants during persistent infection in the stallion: Origin of the 2007 French EAV outbreak was linked to an EAV strain present in the semen of a persistently infected carrier stallion

Virology

Volumn 423, Issue 2, 2012, Pages 165-174

  Miszczak, Fabien ^a,b   Legrand, Loïc ^a,b   Balasuriya, Udeni B R ^c   Ferry Abitbol, Bénédicte ^d   Zhang, Jianqiang ^c   Hans, Aymeric ^e   Fortier, Guillaume ^a,b   Pronost, Stéphane ^a,b   Vabret, Astrid ^b,f  

^a Biology and Innovative Therapeutics for Ovarian Cancers group   (France)

^b UNIVERSITÉ DE CAEN   (France)

^c UNIVERSITY OF KENTUCKY   (United States)

^d Institut Français du Cheval et de l'Equitation IFCE   (France)

^e FRENCH AGENCY FOR FOOD   (France)

^f CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

Emergence; Equine arteritis virus; Outbreak; Persistently infected stallion; Quasispecies; Variants

Indexed keywords

NONSTRUCTURAL PROTEIN 2; SIGNAL PEPTIDE;

5' UNTRANSLATED REGION; ARTICLE; EPIDEMIC; EQUINE VIRAL ARTERITIS; EQUINE VIRAL ARTERITIS VIRUS; FRANCE; GENETIC ANALYSIS; GENETIC VARIABILITY; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SEMEN ANALYSIS; SEQUENCE ANALYSIS; STALLION; SUMMER; VIRUS CARRIER; VIRUS GENOME; VIRUS ISOLATION; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; ARTERITIS VIRUS, EQUINE; ARTERIVIRUS INFECTIONS; BASE SEQUENCE; CARRIER STATE; COMMUNICABLE DISEASES, EMERGING; DISEASE OUTBREAKS; FEMALE; FRANCE; GENETIC VARIATION; HORSE DISEASES; HORSES; MALE; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEMEN; SEQUENCE ALIGNMENT;

EQUIDAE; EQUINE ARTERITIS VIRUS;

EID: 84855813427     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2011.11.028     Document Type: Article

References (35)

1. Balasuriya U.B., Hedges J.F., MacLachlan N.J. Molecular epidemiology and evolution of equine arteritis virus. Adv. Exp. Med. Biol. 2001, 494:19-24.
2. Balasuriya U.B., Hedges J.F., Nadler S.A., McCollum W.H., Timoney P.J., MacLachlan N.J. Genetic stability of equine arteritis virus during horizontal and vertical transmission in an outbreak of equine viral arteritis. J. Gen. Virol. 1999, 80(Pt 8):1949-1958.
3. Balasuriya U.B., Hedges J.F., Smalley V.L., Navarrette A., McCollum W.H., Timoney P.J., Snijder E.J., MacLachlan N.J. Genetic characterization of equine arteritis virus during persistent infection of stallions. J. Gen. Virol. 2004, 85:379-390.
4. Balasuriya U.B., Timoney P.J., McCollum W.H., MacLachlan N.J. Phylogenetic analysis of open reading frame 5 of field isolates of equine arteritis virus and identification of conserved and nonconserved regions in the GL envelope glycoprotein. Virology 1995, 214:690-697.
5. Cavanagh D. Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch. Virol. 1997, 142:629-633.
6. De Vries A.A., Chirnside E.D., Horzinek M.C., Rottier P.J. Structural proteins of equine arteritis virus. J. Virol. 1992, 66:6294-6303.
7. Doll E.R., Bryans J.T., McCollum W.H., Crowe M.E. Isolation of a filterable agent causing arteritis of horses and abortion by mares; its differentiation from the equine abortion (influenza) virus. Cornell Vet. 1957, 47:3-41.
8. Doll E.R., Knappenberger R.E., Bryans J.T. An outbreak of abortion caused by the equine arteritis virus. Cornell Vet. 1957, 47:69-75.
9. Domingo E. Mechanisms of viral emergence. Vet. Res. 2010, 41:38.
10. Firth A.E., Zevenhoven-Dobbe J.C., Wills N.M., Go Y.Y., Balasuriya U.B., Atkins J.F., Snijder E.J., Posthuma C.C. Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production. J. Gen. Virol. 2011, 92:1097-1106.
11. Hall T.A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for windows 95/98/NT. Nucleic Acids Symp. Ser. 1999, 41:95-98.
12. Hedges J.F., Balasuriya U.B., Timoney P.J., McCollum W.H., MacLachlan N.J. Genetic divergence with emergence of novel phenotypic variants of equine arteritis virus during persistent infection of stallions. J. Virol. 1999, 73:3672-3681.
13. Larsen L.E., Storgaard T., Holm E. Phylogenetic characterisation of the G(L) sequences of equine arteritis virus isolated from semen of asymptomatic stallions and fatal cases of equine viral arteritis in Denmark. Vet. Microbiol. 2001, 80:339-346.
14. McCollum W.H., Swerczek T.W. Studies of an epizootic of equine viral arteritis in racehorses. J. Equine Med. Surg. 1978, 2:293-299.
15. McCollum W.H., Timoney P.J., Lee J.J.W., Habacker P.L., Balasuriya U.B.R., MacLachlan N.J. Features of an Outbreak of Equine Viral Arteritis on a Breeding Farm Associated with Abortion and Fatal Interstitial Pneumonia in Neonatal Foals, the Eight International Conference on Equine Infectious Diseases 1999, 559-560. United Arab Emirates, R & W, Dubai. U. Wernery, J.F. Wade, J.A. Mumford, O.R. Kaaden (Eds.).
16. Metz G.E., Ocampos G.P., Serena M.S., Gambaro S.E., Nosetto E., Echeverria M.G. Extended phylogeny of the equine arteritis virus sequences including South American sequences. Intervirology 2011, 54:30-36.
17. Mittelholzer C., Stadejek T., Johansson I., Baule C., Ciabatti I., Hannant D., Paton D., Autorino G.L., Nowotny N., Belak S. Extended phylogeny of equine arteritis virus: division into new subgroups. J. Vet. Med. B Infect. Dis. Vet. Public Health 2006, 53:55-58.
18. Pronost S., Pitel P.H., Miszczak F., Legrand L., Marcillaud-Pitel C., Hamon M., Tapprest J., Balasuriya U.B., Freymuth F., Fortier G. Description of the first recorded major occurrence of equine viral arteritis in France. Equine Vet. J. 2010, 42:713-720.
19. Smith D.B., McAllister J., Casino C., Simmonds P. Virus "quasispecies": making a moutain out of a molehill?. J. Gen. Virol. 1997, 78:1511-1519.
20. Snijder E.J., Meulenberg J.J. The molecular biology of arteriviruses. J. Gen. Virol. 1998, 79(Pt 5):961-979.
21. Snijder E.J., Spaan W.J. Arteriviruses. Fields Virology 2006, 1337-1355. Lippincott Williams & Wilkins, Philadelphia, PA. 5th ed. D.M. Knipe, P.M. Howley, D.E. Griffin, R.A. Lamb, M.A. Martin, B. Roizman, S.E. Straus (Eds.).
22. Snijder E.J., van Tol H., Pedersen K.W., Raamsman M.J., de Vries A.A. Identification of a novel structural protein of arteriviruses. J. Virol. 1999, 73:6335-6345.
23. Tamura K., Duvdley J., Nei M., Kumar S. Molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24:1596-1599.
24. Timoney P.J. Equine viral arteritis: a disease of emerging significance?. Equine Vet. J. 1986, 18:166-168.
25. Timoney P.J., McCollum W.H. Equine viral arteritis. Vet. Clin. North Am. Equine Pract. 1993, 9:295-309.
26. Timoney P.J., McCollum W.H., Roberts A.W., Murphy T.W. Demonstration of the carrier state in naturally acquired equine arteritis virus infection in the stallion. Res. Vet. Sci. 1986, 41:279-280.
27. Van Aken D., Zevenhoven-Dobbe J., Gorbalenya A.E., Snijder E.J. Proteolytic maturation of replicase polyprotein pp 1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7. J. Gen. Virol. 2006, 87:3473-3482.
28. Van Den Born E., Gultyaev A.P., Snijder E.J. Secondary structure and function of the 5'-proximal region of the equine arteritis virus RNA genome. RNA 2004, 10:424-437.
29. Van den Born E., Posthuma C.C., Gultyaev A.P., Snijder E.J. Discontinuous subgenomic RNA synthesis in arteriviruses is guided by an RNA hairpin structure located in the genomic leader region. J. Virol. 2005, 79:6312-6324.
30. Van Dinten L.C., den Boon J.A., Wassenaar A.L., Spaan W.J., Snijder E.J. An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:991-996.
31. Van Dinten L.C., Wassenaar A.L., Gorbalenya A.E., Spaan W.J., Snijder E.J. Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains. J. Virol. 1996, 70:6625-6633.
32. Wieringa R., de Vries A.A., Raamsman M.J., Rottier P.J. Characterization of two new structural glycoproteins, GP(3) and GP(4), of equine arteritis virus. J. Virol. 2002, 76:10829-10840.
33. Zhang J., Miszczak F., Pronost S., Fortier C., Balasuriya U.B., Zientara S., Fortier G., Timoney P.J. Genetic variation and phylogenetic analysis of 22 French isolates of equine arteritis virus. Arch. Virol. 2007, 152:1977-1994.
34. Zhang J., Timoney P.J., Shuck K.M., Seoul G., Go Y.Y., Lu Z., Powell D.G., Meade B.J., Balasuriya U. Molecular epidemiology and genetic characterization of equine arteritis virus isolates associated with the 2006/2007 multi-state disease occurrence in the USA. J. Gen. Virol. 2010, 2286-2301.
35. Ziebuhr J., Snijder E.J., Gorbalenya A.E. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J. Gen. Virol. 2000, 81:853-879.