DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia

British Journal of Haematology

Volumn 156, Issue 3, 2012, Pages 413-414

  Shiba, Norio ^a,b   Taki, Tomohiko ^c   Park, Myoung Ja ^a   Shimada, Akira ^d   Sotomatsu, Manabu ^a   Adachi, Souichi ^e   Tawa, Akio ^f   Horibe, Keizo ^g   Tsuchida, Masahiro ^h   Hanada, Ryoji ⁱ   Tsukimoto, Ichiro ^j   Arakawa, Hirokazu ^b   Hayashi, Yasuhide ^a  

^a Gunma Children's Medical Center   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f OSAKA NATIONAL HOSPITAL   (Japan)

^g NATIONAL HOSPITAL ORGANIZATION   (Japan)

^h Ibaraki Children's Hospital   (Japan)

ⁱ SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

^j TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

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Author keywords

AML; DNMT3A; Myeloproliferative neoplasms; Paediatric

Indexed keywords

COMPLEMENTARY DNA; RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; BLOOD SAMPLING; BONE MARROW; CHILD; CHILDHOOD; CONTROLLED STUDY; DNA METHYLTRANSFERASE 3A GENE; GENE; GENE AMPLIFICATION; GENE DUPLICATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; INFANT; INTERNAL TANDEM DUPLICATION; JUVENILE MYELOMONOCYTIC LEUKEMIA; LETTER; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; MUTATION RATE; MYELODYSPLASTIC SYNDROME; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; RNA EXTRACTION; SCHOOL CHILD;

ACUTE DISEASE; ADOLESCENT; AGE OF ONSET; BONE MARROW CELLS; CHILD; CHILD, PRESCHOOL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EXONS; FEMALE; FMS-LIKE TYROSINE KINASE 3; HUMANS; INFANT; INFANT, NEWBORN; JAPAN; LEUKEMIA, MYELOID; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; MYELODYSPLASTIC SYNDROMES; NEOPLASMS, SECOND PRIMARY; NUCLEAR PROTEINS; RNA, MESSENGER; RNA, NEOPLASM;

EID: 84855801664     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08879.x     Document Type: Letter

References (10)

1. Ho, P.A., Kutny, M.A., Alonzo, T.A., Gerbing, R.B., Joaquin, J., Raimondi, S.C., Gamis, A.S. & Meshinchi, S. (2011) Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group. Pediatric Blood & Cancer, 57, 204-209.
2. Ley, T.J., Ding, L., Walter, M.J., McLellan, M.D., Lamprecht, T., Larson, D.E., Kandoth, C., Payton, J.E., Baty, J., Welch, J., Harris, C.C., Lichti, C.F., Townsend, R.R., Fulton, R.S., Dooling, D.J., Koboldt, D.C., Schmidt, H., Zhang, Q., Osborne, J.R., Lin, L., O'Laughlin, M., McMichael, J.F., Delehaunty, K.D., McGrath, S.D., Fulton, L.A., Magrini, V.J., Vickery, T.L., Hundal, J., Cook, L.L., Conyers, J.J., Swift, G.W., Reed, J.P., Alldredge, P.A., Wylie, T., Walker, J., Kalicki, J., Watson, M.A., Heath, S., Shannon, W.D., Varghese, N., Nagarajan, R., Westervelt, P., Tomasson, M.H., Link, D.C., Graubert, T.A., DiPersio, J.F., Mardis, E.R. & Wilson, R.K. (2010) DNMT3A mutations in acute myeloid leukemia. New England Journal of Medicine, 363, 2424-2433.
3. Pui, C.H., Carroll, W.L., Meshinchi, S. & Arceci, R.J. (2011) Biology, risk stratification, and therapy of pediatric acute leukemias: an update. Journal of Clinical Oncology, 29, 551-565.
4. Shimada, A., Taki, T., Kubota, C., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I. & Hayashi, Y. (2007) No nucleophosmin mutations in pediatric acute myeloid leukemia with normal karyotype: a study of the Japanese Childhood AML Cooperative Study Group. Leukemia, 21, 1307.
5. Shimada, A., Taki, T., Tabuchi, K., Taketani, T., Hanada, R., Tawa, A., Tsuchida, M., Horibe, K., Tsukimoto, I. & Hayashi, Y. (2008) Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese childhood AML Cooperative Study Group. Pediatric Blood & Cancer, 50, 264-269.
6. Stegelmann, F., Bullinger, L., Schlenk, R.F., Paschka, P., Griesshammer, M., Blersch, C., Kuhn, S., Schauer, S., Döhner, H. & Döhner, K. (2011) DNMT3A mutations in myeloproliferative neoplasms. Leukemia, 25, 1217-1219.
7. Thol, F., Heuser, M., Damm, F., Klusmann, J.H., Reinhardt, K. & Reinhardt, D. (2011) DNMT3A mutations are rare in childhood acute myeloid leukemia. Haematologica, 96, 1238-1240.
8. Walter, M.J., Ding, L., Shen, D., Shao, J., Grillot, M., McLellan, M., Fulton, R., Schmidt, H., Kalicki-Veizer, J., O'Laughlin, M., Kandoth, C., Baty, J., Westervelt, P., Dipersio, J.F., Mardis, E.R., Wilson, R.K., Ley, T.J. & Graubert, T.A. (2011) Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia, 25, 1153-1158.
9. Yamashita, Y., Yuan, J., Suetake, I., Suzuki, H., Ishikawa, Y., Choi, Y.L., Ueno, T., Soda, M., Hamada, T., Haruta, H., Takada, S., Miyazaki, Y., Kiyoi, H., Ito, E., Naoe, T., Tomonaga, M., Toyota, M., Tajima, S., Iwama, A. & Mano, H. (2010) Array-based genomic resequencing of human leukemia. Oncogene, 29, 3723-3731.
10. Yan, X.J., Xu, J., Gu, Z.H., Pan, C.M., Lu, G., Shen, Y., Shi, J.Y., Zhu, Y.M., Tang, L., Zhang, X.W., Liang, W.X., Mi, J.Q., Song, H.D., Li, K.Q., Chen, Z. & Chen, S.J. (2011) Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genetics, 43, 309-315.