Promoting research in advanced dementia: Early clinical results of the Alzheimer center reina sofía foundation

Journal of Alzheimer's Disease

Volumn 28, Issue 1, 2012, Pages 211-222

  Olazarán, Javier ^a   Agüera Ortiz, Luis ^b   Osorio, Ricardo S ^a   León Salas, Beatriz ^a   Dobato, José Luis ^a   Cruz Ordua, Isabel ^a   González, Belén ^a   Valentí, Meritxell ^a   Gil Ruiz, Nuria ^a   Frades, Belén ^b   Ramos Garcia M I ^a   Martínez Martín, Pablo ^b  

^a Instituto de Salud Carlos III   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Alzheimer's disease; clinical research protocol; geriatric assessment; inpatients; nursing homes; outpatients; primary senile degenerative dementia

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; CHOLINESTERASE INHIBITOR; HYPNOTIC AGENT; MEMANTINE; NEUROLEPTIC AGENT;

AGED; AGITATION; ALZHEIMER DISEASE; APATHY; ARTICLE; CLINICAL PROTOCOL; COGNITION; DAILY LIFE ACTIVITY; DEMENTIA; DEPRESSION; FEMALE; GAIT DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RESEARCH; MOTOR PERFORMANCE; NURSING HOME PATIENT; PRIORITY JOURNAL; QUALITY OF LIFE;

EID: 84855793918     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110875     Document Type: Article

References (72)

1. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117. (Pubitemid 41797645)
2. Wimo A, Winblad B, Jönsson L (2010) The worldwide societal costs of dementia: Estimates for 2009. Alzheimers Dement 6, 98-103.
3. Martinez-Martin P, Avila J, AD Research Unit Investigators (2010) Alzheimer Center Reina Sofia Foundation: Fighting the disease and providing overall solutions. J Alzheimers Dis 21, 337-348.
4. Walker MP, Ayre GA, Cummings JL, Wesnes K, McKeith IG, OBrien JT, Ballard CG (2000) Quantifying fluctuation in dementia with Lewy bodies, Alzheimers disease, and vascular dementia. Neurology 54, 1616-1625.
5. Dubois B, SlachevskyA, Litvan I, PillonB(2000) The FAB:A Frontal Assessment Battery at bedside. Neurology 55, 1621-1626.
6. Rodriguez del Á lamo A, Catalán AlonsoMJ, CarrascoMaŕn L (2003) FAB: A preliminar Spanish application of the frontal assessment battery to 11 groups of patients]. Rev Neurol 36, 605-608. Article in Spanish].
7. Reisberg B, Ferris SH (1988) Brief Cognitive Rating Scale (BCRS). Psychopharmacol Bull 24, 629-636. (Pubitemid 19054368)
8. Reisberg B, Ferris SH, de Leon MJ, Crook T (1982) The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139, 1136-1139. (Pubitemid 12051593)
9. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140, 566-572. (Pubitemid 12124384)
10. Feldman HH, Jacova C, Robillard A, Garcia A, Chow T, Borrie M, Schipper HM, Blair M, Kertesz A, Chertkow H (2008) Diagnosis and treatment of dementia: 2 Diagnosis.CMAJ178, 825-836.
11. McKhann G, Drachman D, Folstein M, Katzman R, Price D, StadlanEM(1984) Clinical diagnosis of Alzheimers disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimers disease. Neurology 34, 939-944. (Pubitemid 14076461)
12. McKeith IG, Dickson DW, Lowe J, Emre M, OBrien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M (2005) Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology 65, 1863-1872. (Pubitemid 43970103)
13. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF (1998) Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology 51, 1546-1554.
14. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314. (Pubitemid 24382728)
15. Vilalta-Franch J, Lozano-Gallego M, Herńandez-Ferŕandiz M, Llinàs-Regĺa J, Ĺopez-Pousa S, Ĺopez OL (1999) The Neuropsychiatric Inventory: Psychometric properties of its adaptation into Spanish]. Rev Neurol 29, 15-19. Article in Spanish]. (Pubitemid 29459348)
16. Boada M, T́arraga L, Modinos G, Ĺopez OL, Cummings JL (2005) Neuropsychiatric Inventory-Nursing Home version (NPI-NH): Spanish validation]. Neurologia 20, 665-673. Article in Spanish]. (Pubitemid 43082724)
17. Folstein MF, Folstein SE, McHugh PR (1975) "Minimental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
18. Lobo A, Saz P, Marcos G, D́a JL, de la Ćamara C, Ventura T, Morales Aśn F, Fernando Pascual L, Montãńes JA, Aznar S (1999) Revalidation and standardization of the cognition mini-exam (first Spanish version of the Mini-Mental Status Examination) in the general geriatric population]. Med Clin (Barc) 112, 767-774. Article in Spanish].
19. Harrell LE, Marson D, Chatterjee A, Parrish JA (2000) The Severe Mini-Mental State Examination: A new neuropsychologic instrument for the bedside assessment of severely impaired patients with Alzheimer disease. Alzheimer Dis Assoc Disord 14, 168-175.
20. Buiza C, Navarro A, D́az-Orueta U, Gonźalez MF, Alaba J, Arriola E, Herńandez C, Zulaica A, Yanguas JJ. (2011) Short evaluation of cognitive state in advanced stages of dementia: Preliminary results of the Spanish validation of the Severe Mini-Mental State Examination]. Rev Esp Geriatr Gerontol 46, 131-138. Article in Spanish].
21. Weiner MF, Neubecker KE, Bret ME, Hynan LS (2008) Language in Alzheimers disease. J Clin Psychiatry 69, 1223-1227.
22. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimers Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimers disease. Neurology 39, 1159-1165. (Pubitemid 19239715)
23. Pẽna-Casanova J, Quĩnones-Ubeda S, Gramunt-Fombuena N, Quintana-Aparicio M, Aguilar M, Badenes D, Cerulla N, Molinuevo JL, Ruiz E, Robles A, Barquero MS, Ant́unez C, Mart́nez-Parra C, Frank-Garća A, Ferńandez M, Alfonso V, Sol JM, Blesa R (2009) Study NEURONORMA, Team, Spanish Multicenter Normative Studies (NEURONORMA Project): Norms for verbal fluency tests. Arch Clin Neuropsychol 24, 395-411.
24. Borod JC, Goodglass H, Kaplan E (1980) Normative data on the boston diagnostic aphasia examination, parietal lobe battery, and the boston naming test. J Clin Neuropsychol 6, 189-204.
25. Cacho J, Garcia-Garcia R, Arcaya J, Vicente JL, Lantada N (1999) A proposal for application and scoring of the Clock Drawing Test in Alzheimers disease]. Rev Neurol 28, 648-655. Article in Spanish]. (Pubitemid 29232748)
26. Reisberg B (1988) Functional assessment staging (FAST) Psychopharmacol Bull 24, 653-659. (Pubitemid 19054371)
27. Sano M, Egelko S, Jin S, Cummings J, Clark CM, Pawluczyk S, Thomas RJ, Schittini M, Thal LJ (2006) Alzheimers Disease Cooperative Study Group, Spanish instrument protocol: Newtreatment efficacy instruments for Spanish-speaking patients in Alzheimer disease clinical trials. Alzheimer Dis Assoc Disord 20, 232-241. (Pubitemid 44900936)
28. Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of Illness in the Aged. The Index of Adl: A standardized measure of biological and psychosocial function. JAMA 185, 914-919.
29. Alvarez Solar M, de Alaiz Rojo AT, Brun Gurpegui E, Cabã nerosVicente JJ, Calźon Frechoso M, Cośo Rodŕguez I, GarćaĹopez P, Garća-Cãnedo Ferńandez R, Pardo Gonźalez I, Súarez-Gonźalez A (1992) Functional capacity of patients over 65 according to the Katz index. Reliability of the method]. Aten Primaria 10, 812-816.
30. Nourhashemi F, Olde Rikkert MG, Burns A, Winblad B, Frisoni GB, Fitten J, VellasB(2010) Follow-up for Alzheimer patients: European Alzheimer Disease Consortium position paper. J Nutr Health Aging 14, 121-130.
31. Marinus J, Visser M, Stiggelbout AM, Rabey JM, Martinez-Martin P, Bonuccelli U, Kraus PH, van Hilten JJ (2004) A short scale for the assessment of motor impairments and disabilities in Parkinsons disease: The SPES/SCOPA. J Neurol Neurosurg Psychiatry 75, 388-395. (Pubitemid 38338767)
32. Mart́nez-Mart́n P, Benito-Léon J, Burguera JA, Castro A, Linazasoro G, Mart́nez-Castrillo JC,Valldeoriola F, V́azquez A, Vivancos F, del Val J, van Blercom N, Frades B (2005) The SCOPA-motor scale for assessment of Parkinsons disease is a consistent and valid measure. J Clin Epidemiol 58, 674-679.
33. Podsiadlo D, Richardson S (1991) The timed "Up & Go": A test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39, 142-148.
34. Pondal M, del Ser T (2008) Normative data and determinants for the timed "up and go" test in a population-based sample of elderly individuals without gait disturbances. J Geriatr Phys Ther 31, 57-63.
35. Martinez-Martin P, Garcia Urra D, del Ser Quijano T, Balseiro Gomez J, Gomez Utrero E, Pineiro R, Andres MT (1997) A new clinical tool for gait evaluation in Parkinsons disease. Clin Neuropharmacol 20, 183-194. (Pubitemid 27242356)
36. Alonso Frech A, Ĺopez Pousa S, Mart́nez Mart́n P. (2000) Clinical assessment of gait in Alzheimers disease]. Barcelona: LII Meeting of the Spanish Neurological Society. Congress abstract, in Spanish].
37. Volicer L (2007) Goals of care in advanced dementia: Quality of life, dignity and comfort. J Nutr Health Aging 11, 481. (Pubitemid 350247018)
38. Brooks R (1996) EuroQol: The current state of play. Health Policy 37, 53-72. (Pubitemid 26191458)
39. Badia X, Roset M, Montserrat S, Herdman M, Segura A. (1999) The Spanish version of EuroQol: A description and its applications. European Quality of Life scale]. Med Clin (Barc) 112 (Suppl 1), 79-85. Article in Spanish].
40. Baquero M, Peset V, Burguera JA, Salazar-Cifre A, Bosća-Blasco ME, del Olmo-Rodŕguez A, Valero-Merino C, Mũnoz-LacalleRA(2009) on behalf of ENAE/Valencia node, Quality of life in Alzheimers disease]. Rev Neurol 49, 337-342. Article in Spanish].
41. Logsdon RG, Gibbons LE, McCurry SM, Teri L (2002) Assessing quality of life in older adults with cognitive impairment. Psychosom Med 64, 510-519. (Pubitemid 34556417)
42. Léon-Salas B, Logsdon RG, Olazaŕan J, Mart́nez- Mart́n P, MSU-ADRU (2011) Psychometric properties of the Spanish QoL-AD with institutionalized dementia patients and their family caregivers in Spain. Aging Ment Health 15, 775-783.
43. Hobart JC, Riazi A, Lamping DL, Fitzpatrick R, Thompson AJ (2004) Improving the evaluation of therapeutic interventions in multiple sclerosis: Development of a patient-based measure of outcome. Health Technol Assess 8, 1-48.
44. McHorney CA, Tarlov AR (1995) Individual-patient monitoring in clinical practice: Are available health status surveys adequate? Qual Life Res 4, 293-307.
45. Hays RD, Anderson R, Revicki D (1993) Psychometric considerations in evaluating health-related quality of life measures. Qual Life Res 2, 441-449. (Pubitemid 24035216)
46. Saxton J, Swihart AA (1989) Neuropsychological assessment of the severely impaired elderly patient. Clin Geriatr Med 5, 531-543. (Pubitemid 19207868)
47. Llinàs Regĺa J, Lozano Gallego M, Ĺopez OL, Gudayol Portabella M, Ĺopez-Pousa S, Vilalta Franch J, Saxton J (1995) Validation of the Spanish version of the Severe Impairment Battery]. Neurologia 10, 14-18. Article in Spanish].
48. Agüera-Ortiz LF, Cruz-Ordũna I, Ramos-Garća MI, Valent́-Soler M, Gil-Ruiz N, Osorio-Súarez RM, Dobato JL, Olazaŕan-Rodŕguez J, Léon-Salas B, Mart́nez- Mart́n P (2011) The process of creating the APADEM-NH scale for the measurement of apathy in institutionalised patients with dementia]. Psicogeriatra 3, 29-36. Article in Spanish].
49. Cohen-Mansfield J, Marx MS, Rosenthal AS (1989) A description of agitation in a nursing home. J Gerontol 44, M77-M84. (Pubitemid 19130580)
50. Cervilla JA, Rodriguez Cano T, Gurpegui M (1995) Prevalence of agitated behaviour in old people]. Anales de Psiquiatra 11 (Suppl 1), 5-6. Article in Spanish].
51. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA (1988) Cornell scale for depression in dementia. Biol Psychiatry 23, 271-284. (Pubitemid 18047596)
52. Pujol J, De Azpiazu P, Salamero M, CuevasR(2001) Depressive symptoms in dementia. The cornell scale: Validation of the Spanish version]. Rev Neurol 33, 397-398. Article in Spanish]. (Pubitemid 32971544)
53. Mohamed S, Rosenheck R, Lyketsos CG, Schneider LS (2010) Caregiver burden in Alzheimer disease: Crosssectional and longitudinal patient correlates. Am J Geriatr Psychiatry 18, 917-927.
54. Banerjee S, Murray J, Foley B, Atkins L, Schneider J, MannA (2003) Predictors of institutionalisation in people with dementia. J Neurol Neurosurg Psychiatry 74, 1315-1316.
55. Osborne H, Simpson J, Stokes G (2010) The relationship between pre-morbid personality and challenging behaviour in people with dementia: A systematic review. Aging Ment Health 14, 503-515.
56. Costa PTJ, McCrae RR (1992) Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual, Psychological Assessment Resources, Odessa, FL.
57. Costa PTJ, McCrae RR (2002) NEO Five-Factor Inventory (NEO-FFI) professional manual], TEA Ediciones, Madrid. Spanish Manual].
58. Mahoney FI, Barthel DW (1965) Functional evaluation: The Barthel Index. Md State Med J 14, 61-65.
59. Cid-Ruzafa J, Damían-Moreno J (1997) Disability evaluation: Barthels index]. Rev Esp Salud Publica 71, 127-137. Article in Spanish].
60. Lawton MP, Brody EM (1969) Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 9, 179-186.
61. Olazaŕan J, Mouronte P, Bermejo F (2005) Clinical validity of two scales of instrumental activities in Alzheimers disease]. Neurologia 20, 395-401. Article in Spanish]. (Pubitemid 41640923)
62. Rolland Y, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, Riviere D, Vellas B (2007) Exercise program for nursing home residents with Alzheimers disease: A 1-year randomized, controlled trial. J Am Geriatr Soc 55, 158-165. (Pubitemid 46184389)
63. Tinetti ME (1986) Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc 34, 119-126. (Pubitemid 16159911)
64. Salv́a A, Bolibar I, Lucas R, Rojano-Luque X (2005) Use of the POMA for the assessment of balance and gait in community-dwelling old people]. Rev Esp Geriatr Gerontol (Suppl 2) 36-44. Article in Spanish]. (Pubitemid 43035811)
65. Santana-Sosa E, Barriopedro MI, Ĺopez-Mojares LM, Ṕerez M, Lucia A (2008) Exercise training is beneficial for Alzheimers patients. Int J Sports Med 29, 845-850.
66. Weiner MF, Martin-Cook K, Svetlik DA, Saine K, Foster B, Fontaine CS (2000) The quality of life in late-stage dementia (QUALID) scale. J Am Med Dir Assoc 1, 114-116.
67. Garre-Olmo J, Planas-Pujol X, Ĺopez-Pousa S, Weiner MF, Turon-Estrada A, Juvinyà D, Ballester D, Vilalta-Franch J (2010) Cross-cultural adaptation and psychometric validation of a Spanish version of the Quality of Life in Late-Stage Dementia Scale. Qual Life Res 19, 445-453.
68. Jeste DV, Blazer D, Casey D, Meeks T, Salzman C, Schneider L, Tariot P, Yaffe K (2008) ACNP white paper: Update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology 33, 957-970. (Pubitemid 351367549)
69. Moniz-Cook E, Vernooij-Dassen M, Woods R, Verhey F, Chattat R, De Vugt M, Mountain G, OConnell M, Harrison J, Vasse E, Droes RM, Orrell M (2008) A European consensus on outcome measures for psychosocial intervention research in dementia care. Aging Ment Health 12, 14-29. (Pubitemid 351302403)
70. Venturato L (2010) Dignity, dining and dialogue: Reviewing the literature on quality of life for people with dementia. Int J Older People Nurs 5, 228-234.
71. Ettema TP, Dröes RM, de Lange J, Ooms ME, Mellenbergh GJ, RibbeMW(2005) The concept of quality of life in dementia in the different stages of the disease. Int Psychogeriatr 17, 353-370. (Pubitemid 41391682)
72. Weintraub S, Salmon D, Mercaldo N, Ferris S, Graff-Radford NR, Chui H, Cummings J, DeCarli C, Foster NL, Galasko D, Peskind E, Dietrich W, Beekly DL, Kukull WA, Morris JC (2009) The Alzheimers disease centers Uniform Data Set (UDS): The neuropsychologic test battery. Alzheimer Dis Assoc Disord 23, 91-101.