Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells

Clinical and Experimental Immunology

Volumn 167, Issue 2, 2012, Pages 252-260

  Adar, T ^a   Ben Ya'acov, A ^a   Lalazar, G ^a   Lichtenstein, Y ^a   Nahman, D ^a   Mizrahi, M ^a   Wong, V ^b   Muller, B ^b   Rawlin, G ^b   Ilan, Y ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b Immuron Limited   (Australia)

Author keywords

Colostrum; NASH; NKT cells; TNF ; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLESTEROL; GLUCOSE; IMMUNOGLOBULIN G; LIVER ENZYME; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; COLOSTRUM; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIVER INJURY; MOUSE; NATURAL KILLER CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CATTLE; COLOSTRUM; DRUG EVALUATION, PRECLINICAL; ENTEROTOXIGENIC ESCHERICHIA COLI; FATTY LIVER; FEMALE; GLUCOSE INTOLERANCE; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; IMMUNOTHERAPY; INFLAMMATION; INSULIN RESISTANCE; LIPOPOLYSACCHARIDES; LYMPHOCYTE COUNT; MALE; MICE; MICE, OBESE; NATURAL KILLER T-CELLS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855777705     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04511.x     Document Type: Article

References (35)

1. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003; 27 (Suppl. 3):S53-5.
2. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444:860-7.
3. Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006; 131:934-45.
4. Gabriely I, Ma XH, Yang XM etal. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 2002; 51:2951-8.
5. Xu H, Barnes GT, Yang Q etal. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-30.
6. Ouchi N, Kihara S, Arita Y etal. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 1999; 100:2473-6.
7. Hotta K, Funahashi T, Arita Y etal. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000; 20:1595-9.
8. Trujillo ME, Scherer PE. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005; 257:167-75.
9. Kudo H, Takahara T, Yata Y, Kawai K, Zhang W, Sugiyama T. Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. J Hepatol 2009; 51:168-75.
10. Verdam FJ, Rensen SS, Driessen A, Greve JW, Buurman WA. Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis. J Clin Gastroenterol 2011; 45:149-52.
11. Ruiz AG, Casafont F, Crespo J etal. Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis. Obes Surg 2007; 17:1374-80.
12. Miele L, Valenza V, La Torre G etal. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 2009; 49:1877-87.
13. Day CP, James OF. Steatohepatitis: a tale of two 'hits'. Gastroenterology 1998; 114:842-5.
14. Guebre-Xabier M, Yang S, Lin HZ, Schwenk R, Krzych U, Diehl AM. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. Hepatology 2000; 31:633-40.
15. Li Z, Oben JA, Yang S etal. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 2004; 40:434-41.
16. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A. A thymic precursor to the NK T cell lineage. Science 2002; 296:553-5.
17. Li Z, Lin H, Yang S, Diehl AM. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology 2002; 123:1304-10.
18. Struff WG, Sprotte G. Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment. Int J Clin Pharmacol Ther 2007; 45:193-202.
19. Struff WG, Sprotte G. Bovine colostrum as a biologic in clinical medicine: a review-Part II: clinical studies. Int J Clin Pharmacol Ther 2008; 46:211-25.
20. Loimaranta V, Tenovuo J, Virtanen S etal. Generation of bovine immune colostrum against Streptococcus mutans and Streptococcus sobrinus and its effect on glucose uptake and extracellular polysaccharide formation by mutans streptococci. Vaccine 1997; 15:1261-8.
21. Loimaranta V, Nuutila J, Marnila P, Tenovuo J, Korhonen H, Lilius EM. Colostral proteins from cows immunised with Streptococcus mutans/S. sobrinus support the phagocytosis and killing of mutans streptococci by human leucocytes. J Med Microbiol 1999; 48:917-26.
22. Golay A, Ferrara JM, Felber JP, Schneider H. Cholesterol-lowering effect of skim milk from immunized cows in hypercholesterolemic patients. Am J Clin Nutr 1990; 52:1014-19.
23. Mero A, Miikkulainen H, Riski J, Pakkanen R, Aalto J, Takala T. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol 1997; 83:1144-51.
24. Severin S, Wenshui X. Milk biologically active components as nutraceuticals: review. Crit Rev Food Sci Nutr 2005; 45:645-56.
25. Buescher ES, McWilliams-Koeppen P. Soluble tumor necrosis factor-alpha (TNF-alpha) receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivity. Pediatr Res 1998; 44:37-42.
26. Garofalo RP, Goldman AS. Cytokines, chemokines, and colony-stimulating factors in human milk: the 1997 update. Biol Neonate 1998; 74:134-42.
27. Neville MC. Anatomy and physiology of lactation. Pediatr Clin North Am 2001; 48:13-34.
28. Korhonen H, Marnila P, Gill HS. Milk immunoglobulins and complement factors. Br J Nutr 2000; 84 (Suppl. 1):S75-80.
29. Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. J Infect Dis 1987; 156:158-66.
30. Dohm GL, Elton CW, Raju MS etal. IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM. Diabetes 1990; 39:1028-32.
31. Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS. Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Diabetes 2002; 51:1876-83.
32. Feldstein AE, Werneburg NW, Canbay A etal. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004; 40:185-94.
33. Lira FS, Rosa JC, Pimentel GD etal. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects. Lipids Health Dis 2010; 9:82.
34. Ewaschuk J, Endersby R, Thiel D etal. Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis. Hepatology 2007; 46:841-50.
35. de Rham O, Isliker H. Proteolysis of bovine immunoglobulins. Int Arch Allergy Appl Immunol 1977; 55:61-9.