PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 67, Issue 2, 2012, Pages 175-182

  Obiri, D D ^a   Flink, N ^a   Maier, J V ^a   Neeb, A ^a   Maddalo, D ^a   Thiele, W ^a   Menon, A ^a   Stassen, M ^b   Kulkarni, R A ^c   Garabedian, M J ^d   Barrios, A M ^c   Cato, A C B ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY OF UTAH   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

calcium influx; degranulation; dexamethasone; mast cells; PTPN22

Indexed keywords

DEXAMETHASONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; PEST DOMAIN ENRICHED TYROSINE PHOSPHATASE; PHOSPHOLIPASE C GAMMA1; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; CROSS LINKING; DEGRANULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE DELETION; HEMATOPOIETIC CELL; MAST CELL; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANAPHYLAXIS; ANIMALS; CALCIUM SIGNALING; CELL DEGRANULATION; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; IMMUNOLOGIC FACTORS; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOLIPASE C GAMMA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12;

EID: 84855764414     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2011.02731.x     Document Type: Article

References (24)

1. Galli SJ, Grimbaldeston M, Tsai M,. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008; 8: 478-486. (Pubitemid 351733419)
2. Gilfillan AM, Rivera J,. The tyrosine kinase network regulating mast cell activation. Immunol Rev 2009; 228: 149-169.
3. Arimura Y, Yagi J,. Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells. Sci Signal 2010; 3: rs1.
4. Maier JV, Brema S, Tuckermann J, Herzer U, Klein M, Stassen M, et al., Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids. Mol Endocrinol 2007; 21: 2663-2671. (Pubitemid 350035149)
5. Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato AC,. Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 2001; 20: 7108-7116. (Pubitemid 34062302)
6. Matthews RJ, Bowne DB, Flores E, Thomas ML,. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. Mol Cell Biol 1992; 12: 2396-2405.
7. Gjorloff-Wingren A, Saxena M, Williams S, Hammi D, Mustelin T,. Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP. Eur J Immunol 1999; 29: 3845-3854.
8. Cloutier JF, Veillette A,. Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 1999; 189: 111-121. (Pubitemid 29047031)
9. Vang T, Miletic AV, Bottini N, Mustelin T,. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity 2007; 40: 453-461. (Pubitemid 47343357)
10. Mustelin T, Vang T, Bottini N,. Protein tyrosine phosphatases and the immune response. Nat Rev Immunol 2005; 5: 43-57. (Pubitemid 40070330)
11. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB,. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002; 297: 1689-1692. (Pubitemid 35000781)
12. Benoist C, Mathis D,. Mast cells in autoimmune disease. Nature 2002; 420: 875-878. (Pubitemid 36019641)
13. Secor VH, Secor WE, Gutekunst CA, Brown MA,. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J Exp Med 2000; 191: 813-822.
14. Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC,. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 2004; 303: 685-689. (Pubitemid 38141637)
15. Karver MR, Krishnamurthy D, Bottini N, Barrios AM,. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. J Inorg Biochem 2010; 104: 268-273.
16. Furuichi T, Yoshikawa S, Miyawaki A, Wada K, Maeda N, Mikoshiba K,. Primary structure and functional expression of the inositol 1,4,5-trisphosphate- binding protein P400. Nature 1989; 342: 32-38. (Pubitemid 19271115)
17. Peavy RD, Metcalfe DD,. Understanding the mechanisms of anaphylaxis. Curr Opin Allergy Clin Immunol 2008; 8: 310-315.
18. Gilfillan AM, Tkaczyk C,. Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 2006; 6: 218-230. (Pubitemid 43290991)
19. Metcalfe DD, Peavy RD, Gilfillan AM,. Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol 2009; 124: 639-646; quiz 647-648.
20. Cissel DS, Beaven MA,. Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells. J Biol Chem 2000; 275: 7066-7070. (Pubitemid 30146253)
21. Andrade MV, Hiragun T, Beaven MA,. Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. J Immunol 2004; 172: 7254-7262. (Pubitemid 38747584)
22. Hiragun T, Peng Z, Beaven MA,. Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Mol Pharmacol 2005; 67: 598-603. (Pubitemid 40365306)
23. Hiragun T, Peng Z, Beaven MA,. Cutting edge: dexamethasone negatively regulates Syk in mast cells by up-regulating SRC-like adaptor protein. J Immunol 2006; 177: 2047-2050. (Pubitemid 44200960)
24. Rider LG, Hirasawa N, Santini F, Beaven MA,. Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells. J Immunol 1996; 157: 2374-2380. (Pubitemid 126450447)