A randomized trial of ovulation induction with two different doses of Letrozole in women with PCOS

Archives of Gynecology and Obstetrics

Volumn 284, Issue 4, 2011, Pages 1029-1034

  Ramezanzadeh, Fatemeh ^a   Nasiri, Roya ^b   Yazdi, Mohammad Sarafraz ^b   Baghrei, Maryam ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Follicle; Letrozole; Ovulation; Polycystic ovary syndrome; Pregnancy

Indexed keywords

LETROFEM; LETROZOLE; PROGESTERONE; TESTOSTERONE; UNCLASSIFIED DRUG; FERTILITY PROMOTING AGENT; NITRILE; TRIAZOLE DERIVATIVE;

ADULT; ARTICLE; CLINICAL EFFECTIVENESS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; FEMALE INFERTILITY; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OUTCOME ASSESSMENT; OVARY FOLLICLE MATURATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; CLINICAL TRIAL; COITUS; CONTROLLED CLINICAL TRIAL; DRUG ADMINISTRATION; OVARY FOLLICLE; PREGNANCY; TREATMENT OUTCOME;

ADULT; COITUS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; MENSTRUAL CYCLE; NITRILES; OVARIAN FOLLICLE; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TRIAZOLES;

EID: 84855741525     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-011-1951-5     Document Type: Article

References (34)

1. Young SL, Opsahl MS, Fritz MA (1999) Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women. Fertil Steril 71(4):639-644 (Pubitemid 29149412)
2. Mikkelson TJ, Kroboth PO, Cameron WJ, Dittert LW, Chungi Y, Manberg PJ (1986) Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril 46(3):392-396 (Pubitemid 16025583)
3. Gonen Y, Casoer RF (1990) Sonographic determination of an adverse effect of clomiphene citrate on endometrial growth. Hum Reprod 5(6):670-674 (Pubitemid 20308440)
4. Sereepapong W, Triratanachat S, Sampatanukul P, Pruksananonda K, Boonkasemsanti K, Reinprayoon D (2000) Effects of clomiphene citrate on the endometrium of regularly cycling women. Fertil Steril 73(2):287-291 (Pubitemid 30060361)
5. Homburg R (2005) Clomiphene citrate-end of an era? a minireview. Hum Reprod 20(8):2043-2051 Epub 2005 May 5
6. Al-Fozan H, Al-Khadouri M, Tan SL, Tulandi T (2004) A randomized trial of Letrozole versus clomiphene citrate in women undergoing superovulation. Fertil Steril 82(6):1561-1563 (Pubitemid 39611383)
7. Franks S, Adams J, Mason H, Polson D (1985) Ovulatory disorders in women with polycystic ovary syndrome. Clin Obstet Gynecol 12(3):605-632 (Pubitemid 16214244)
8. Kistner RW (1965) Induction of ovulation with clomiphene citrate (clomid). Obstet Gynecol Survey 20(6):873-900
9. Mitwally M, Biljan M, Casper R (2005) Pregnancy outcome after the use of an aromatase inhibitor for ovarian stimulation. Am J Obstet Gynecol 192(2):381-386 (Pubitemid 40214968)
10. Mitwally M, Casper RF (2000) Aromatase inhibition: a novel method of ovulation induction in women with polycystic ovarian syndrome. Reprod Technol 10:244-247
11. Mitwally M, Casper R (2001) Use of aromatase inhibitor for ovulation induction in patients with an inadequate response to clomiphene citrate. Fertil Steril 75(2):305-309 (Pubitemid 32112106)
12. Casper RF (2003) Letrozole: ovulation or superovulation? Fertil Steril 80(6):1335-1337 discussion 1339 (Pubitemid 37532443)
13. Casper RF, Mitwally MF (2006) Review: aromatase inhibitors for ovulation induction. J Clin Endocrinol Metab 91(3):760-771 Epub 2005 Dec 29 (Pubitemid 43361917)
14. Baruah J, Roy kk, Rahman SM, Kumar S, Sharma JB, Karmakar D (2009) Endometrial effects of Letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler. Arch Gynecol Obstet 279(3):311-314 Epub 2008 Jul 3
15. Badawy A, Aal IA, Abulatta M (2009) Clomiphene citrate or Letrozole for ovulation induction in women with polycysiic ovarian syndrome: a prospective rundomized trial. Fertil Steril 92(3):849-852
16. Begum MR, Ferdous J, Begum A, Quadir E (2009) Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulaltion in polycystic ovarian syndrome. Fertil Steril 92(3):853-857
17. Sohrabvand F, Ansari Sh, Bagheri M (2006) Efficacy of combined metformin-Letrozole in comparison with metformin- clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. Hum Reprod 21(6):1432-1435 (Pubitemid 44445018)
18. Atay V, Cam C, Muhcu M, Cam M, Karateke A (2006) Comparison of Letrozole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation. J Int Med Res 34(1):73-76
19. Ganesh A, Goswami SK, Chattopadhyay R, Chaudhury K, Chakravarty B (2009) Comparison of Letrozole with continuous gonadotropins and clomiphene- gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial. J Assist Reprod Genet 26(1):19-24 Epub 2009 Jan 7
20. Bayar U, Basaran M, Kiran S, Coskun A, Gezer S (2006) Use of an aromatase inhibitor in patients with polycystic ovary syndrome: a prospective randomized trial. Fertil Steril 86(5): 1447-1451 (Pubitemid 44602052)
21. Zeinalzadeh M, Basirat Z, Esmailpour M (2010) Efficacy of Letrozole in ovulation induction compared to that of clomiphene citrate in patients with polycystic ovarian syndrome. J Reprod Med 55(1-2):36-40
22. Abu Hashim H, Shokeir T, Badawy A (2010) Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. Fertil Steril 94(4):1405-1409 Epub 2009 Sep 3
23. Yang MQ, Quan S, Li H, Song YL, Xing FQ (2008) Effect of two different doses of Letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome. Nan Fang Yi Ke Da Xue Xue Bao 28(11):2060-2061
24. Al-Fadhli R, Sylvestre C, Buckett W, Tan SL, Tulandi T (2006) A randomized trial of superovulation with two different doses of Letrozole. Fertil Steril 85(1):161-164 (Pubitemid 43063440)
25. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (2004) Fertil Steril 81(1):19-25
26. Guzick D (1998) Polycystic ovary syndrome.symptomatology, pathophysiology and epidemiology. Am J Obstet Gynecol 179(6 Pt 2):S89-S93 (Pubitemid 29022148)
27. Casper RF (2009) Letrozole versus clomiphene citrate: which is better for ovulation induction? Fertil Steril 92(3):858-859 (Epub 2007 Jun 27)
28. Tulandi T, Martin J, Al-Fadhli R, Kabli N, Forman R, Hitkari J et al (2006) Congenital malformations among 911 newborns conceived after infertility treatment with Letrozole or clomiphene citrate. Fertil Steril 85(6):1761-1765 (Epub 2006 May 2) (Pubitemid 43816444)
29. Badawy A, Shokeir T, Allam AF, Abdelhady H (2009) Pregnancy outcome after ovulalion induction with aromatase inhibitors or clomiphene citrate in unexplained infertility. Acta Obstet Gynecol Scand 88(2):187-191
30. Badawy A, Mosbah A, Tharwat A, Eid M (2009) Extended Letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol. Fertil Steril 92(1):236-239 (Epub 2008 Aug 15)
31. Ramezanzadeh F, Seifi J, Masumi M, Jafarabadi M (2007) Single dose Letrozole versus 5 day course in ovulation induction for in vivo fertilization. Hum Reprod 22(Suppl 1):IJ36
32. Badawy A, Mitwally M, Fawzy M (2007) Randomized controlled trial of three doses of Letrozole for ovulation induction in patients with unexplained inferlilily. Reprod Biomed Online 14(5):559-562
33. Messinis IE (2005) Ovulation induction: a mini review. Hum Reprod 20(10):2688-2697 (Pubitemid 41487621)
34. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome (2008). Fertil Steril 89(3):505-5022. (Epub 2008 Feb 20)