Elevated serum epidermal growth factor receptor level is correlated with lymph node metastasis in lung cancer

International Journal of Clinical Oncology

Volumn 8, Issue 2, 2003, Pages 79-82

  Sasaki, Hidefumi ^a   Yukiue, Haruhiro ^a   Mizuno, Kotaro ^a   Sekimura, Atsushi ^a   Konishi, Akimitsu ^a   Yano, Motoki ^a   Kaji, Masahiro ^a   Kiriyama, Masanobu ^a   Fukai, Ichiro ^a   Yamakawa, Yosuke ^a   Fujii, Yoshitaka ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

EGFR; Lung cancer; Lymph node metastasis

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER DIAGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; ENZYME IMMUNOASSAY; HUMAN; LUNG CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS;

AGED; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LINEAR MODELS; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROBABILITY; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REFERENCE VALUES; RISK ASSESSMENT; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0038336158     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s101470300014     Document Type: Article

References (21)

1. Rusch V, Mendelsohn, J, Dmitrovsky E (1996) The epidermal growth factor receptor and its ligands as therapeutic targets in human tumors. Cytokine Growth Factor Rev 7:133-141
2. Rusch V, Baselga J, Cordon-Cardo C, et al. (1993) Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 53:2379-2385
3. Fujino S, Enokibori T, Tezuka N, et al. (1996) A comparison of epidermal growth factor receptor levels and other prognositc parameters in non-small cell lung cancer. Eur J Cancer 32:2070-2074
4. Fontanini G, De Laurentiis M, Vignati S, et al. (1998) Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 4:241-249
5. Salomon DS, Brandt R, Ciardiello F, et al. (1995) Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232
6. Volm M, Rottgen W, Drings P (1998) Prognostic value of ERBB-1, VEGF, cyclin A, Fos, JUN and MYC in patients with squamous cell lung carcinomas. Br J Cancer 77:663-669
7. Rusch V, Klimstra D, Venkatraman E, et al. (1997) Over-expression of the epidermal growth factor receptor and its ligand transforming growth factor alpha is frequent in resectable non-small cell lung cancer but does not predict tumor progression. Clin Cancer Res 2:515-522
8. Pastorino U, Andreola S, Tagliabue E, et al. (1997) Immunocytochemical markers in stage I lung cancer: relevance to prognosis. J Clin Oncol 15:2858-2865
9. Fontanini G, Vignati S, Bigini D, et al. (1995) Epidermal growth factor receptor (EGFR) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur J Cancer 31A:178-183
10. Pfeiffer P, Clausen PP, Andersen K, et al. (1996) Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections. Br J Cancer 74:86-91
11. Parsons JT, Parsons SJ (1993) Protein-tyrosine kinase, oncogenes and cancer. In: DeVita VT, Hellmann S, Rosenberg SA (eds) Important advances in oncology. Lippincott-Raven, Philadelphia, pp 3-18
12. Gill G, Bertics P, Santon J (1994) Epidermal growth factor and its receptor. Mol Cell Endocrinol 51:169-186
13. Carpenter G, Cohen S (1979) Epidermal growth factor. Ann Rev Biochem 48:193-216
14. Ambs KE, Takahashi A, Hering F, et al. (1989) Epidermal growth factor receptor in adenocarcinoma of the kidney. Urol Res 17:251-254
15. Choi JH, Oh JY, Ruy SK, et al. (1997) Detection of epidermal growth factor in the serum of gastric carcinoma patients. Cancer 79:1879-1893
16. Schneider J, Presek P, Braun A, et al. (1999) p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer. Am J Ind Med 36:602-609
17. Japan Lung Cancer Society (1999) General rules for clinical and pathological records of lung cancer, 5th edn. Kanehara, Tokyo, pp 1-177
18. Haeder M, Rotsch M, Bepler G, et al. (1988) Epidermal growth factor receptor expression in human lung cancer cell lines. Cancer Res 48:1132-1136
19. Sozzi G, Miozzo M, Tagliabue E, et al. (1991) Catogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients. Cancer Res 51:400-404
20. Birrer MJ, Brown PH (1992) Application of molecular genetics to the early diagnosis and screening of lung cancer. Cancer Res 52:2658s-2664s
21. Pavelic K, Banjac Z, Pavelic J, Spaventi S (1993) Evidence for a role of EGF receptor in the progression of human lung carcinoma. Anticancer Res 14:1133-1137