메뉴 건너뛰기




Volumn 46, Issue 11, 2011, Pages 1374-1379

Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration

Author keywords

Metabolite; Sinisan; UPLC Q TOF MS

Indexed keywords

AURANTIIN; DRUG METABOLITE; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; HESPERIDIN; LIQUIRITIGENIN; LIQUIRITIN; NEOHESPERIDIN; SAIKOSAPONIN A; SAIKOSAPONIN D; SINISAN EXTRACT; UNCLASSIFIED DRUG;

EID: 84855678610     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (20)

References (15)
  • 1
    • 57249113708 scopus 로고    scopus 로고
    • Possible therapeutic effect of a traditional Chinese medicine, Sinisan, on chronic restraint stress related disorders
    • [J]
    • Wang YT, Tan QR, Sun LL, et al. Possible therapeutic effect of a traditional Chinese medicine, Sinisan, on chronic restraint stress related disorders [J]. Neurosci Lett, 2009, 449: 215-219.
    • (2009) Neurosci Lett , vol.449 , pp. 215-219
    • Wang, Y.T.1    Tan, Q.R.2    Sun, L.L.3
  • 2
    • 0037165568 scopus 로고    scopus 로고
    • Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS
    • DOI 10.1021/jf011384v
    • Fang N, Yu S, Bader TM. Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS [J]. J Agric Food Chem, 2002, 50: 2700-2707. (Pubitemid 34437390)
    • (2002) Journal of Agricultural and Food Chemistry , vol.50 , Issue.9 , pp. 2700-2707
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 3
    • 78651331250 scopus 로고    scopus 로고
    • Identification of flavonoid metabolites of Fructus Aurantii Immaturus in rat biological samples by liquid chromatography-tandem mass spectrometry
    • [J]
    • Li Z, Song R, Xu FG, et al. Identification of flavonoid metabolites of Fructus Aurantii Immaturus in rat biological samples by liquid chromatography-tandem mass spectrometry [J]. J China Pharm Univ, 2010, 41: 539-547.
    • (2010) J China Pharm Univ , vol.41 , pp. 539-547
    • Li, Z.1    Song, R.2    Xu, F.G.3
  • 4
    • 79551503789 scopus 로고    scopus 로고
    • In vitro metabolism of glycyrrhetic acid by human cytochrome P450
    • [J]
    • Liu L, Xiao J, Peng ZH, et al. In vitro metabolism of glycyrrhetic acid by human cytochrome P450 [J]. Acta Pharm Sin, 2011, 46: 81-87.
    • (2011) Acta Pharm Sin , vol.46 , pp. 81-87
    • Liu, L.1    Xiao, J.2    Peng, Z.H.3
  • 5
    • 70350063681 scopus 로고    scopus 로고
    • Influence of glycyrrhizin on paeoniflorin pharmacokinetic fate in unrestrained conscious rats by intravenous administration
    • [J]
    • Li N, Chen XJ, Han D, et al. Influence of glycyrrhizin on paeoniflorin pharmacokinetic fate in unrestrained conscious rats by intravenous administration [J]. China J Chin Mater, 2009, 34: 1720-1723.
    • (2009) China J Chin Mater , vol.34 , pp. 1720-1723
    • Li, N.1    Chen, X.J.2    Han, D.3
  • 6
    • 77956809378 scopus 로고    scopus 로고
    • UPLC-Q-TOF/MS analysis of naringin and naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri Grandis
    • [J]
    • Sun GL, Qian DW, Duan JA, et al. UPLC-Q-TOF/MS analysis of naringin and naringenin and its metabolites in rat urine and feces after intragastric administration of alcohol extract of Exocarpium Citri Grandis [J]. Acta Pharm Sin, 2010, 45: 761-766.
    • (2010) Acta Pharm Sin , vol.45 , pp. 761-766
    • Sun, G.L.1    Qian, D.W.2    Duan, J.A.3
  • 7
    • 11944251471 scopus 로고    scopus 로고
    • Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS
    • DOI 10.1039/b412577k
    • Zhang JM, Brodbelt JS. Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS [J]. Analyst, 2004, 129: 1227-1233. (Pubitemid 40100999)
    • (2004) Analyst , vol.129 , Issue.12 , pp. 1227-1233
    • Zhang, J.1    Brodbelt, J.S.2
  • 8
    • 33748902567 scopus 로고    scopus 로고
    • Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data
    • DOI 10.1124/dmd.106.009241
    • Zhu MS, Ma L, Zhang DL, et al. Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data [J]. Drug Metab Dispos, 2006, 34: 1722-1733. (Pubitemid 44427475)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1722-1733
    • Zhu, M.1    Ma, L.2    Zhang, D.3    Ray, K.4    Zhao, W.5    Humphreys, W.G.6    Skiles, G.7    Sanders, M.8    Zhang, H.9
  • 9
    • 6344291786 scopus 로고    scopus 로고
    • Identification and quantification of the conjugated metabolites derived from orally administered besperidin in rat plasma
    • [J]
    • Matsumoto H, Ikorna Y, Sugiura M, et al. Identification and quantification of the conjugated metabolites derived from orally administered besperidin in rat plasma [J]. J Agric Food Chem, 2004, 52: 6653-6659.
    • (2004) J Agric Food Chem , vol.52 , pp. 6653-6659
    • Matsumoto, H.1    Ikorna, Y.2    Sugiura, M.3
  • 11
    • 0025022724 scopus 로고
    • Metabolism of glycyrrhetic acid by rat liver microsomes: Glycyrrhetinate dehydrogenase
    • DOI 10.1016/0005-2760(90)90015-P
    • Akao T, Akao T, Kobashi K. Metabolism of glycyrrhetic acid by rat liver microsomes: glycyrrhetinate dehydrogenase [J]. Biochim biophys Acta, 1990, 1042: 241-246. (Pubitemid 20043455)
    • (1990) Biochimica et Biophysica Acta - Lipids and Lipid Metabolism , vol.1042 , Issue.2 , pp. 241-246
    • Akao, T.1    Akao, T.2    Kobashi, K.3
  • 12
    • 0022406943 scopus 로고
    • Structural transformation of saikosaponins by gastric juice and intestinal flora
    • Shimizu K, Amagaya A, Ogihara Y. Structural transformation of saikosaponins by gastric juice and intestinal flora [J]. J Pharmacobiodyn, 1985, 8: 718-725. (Pubitemid 16232605)
    • (1985) Journal of Pharmacobio-Dynamics , vol.8 , Issue.9 , pp. 718-725
    • Shimizu, K.1    Amagaya, S.2    Ogihara, Y.3
  • 13
    • 76049105665 scopus 로고    scopus 로고
    • Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs
    • [J]
    • Xie T, Liang Y, Hao HP, et al. Advances in study of metabolic activation of carboxyl-acid containing drugs by UGTs [J]. Acta Pharm Sin, 2009, 44: 1193-1199.
    • (2009) Acta Pharm Sin , vol.44 , pp. 1193-1199
    • Xie, T.1    Liang, Y.2    Hao, H.P.3
  • 15
    • 79958783273 scopus 로고    scopus 로고
    • Absorption of flavonoids from Abelmoschus manihot extract by in situ intestinal perfusion
    • [J]
    • Xue CF, Guo JM, Qian DW, et al. Absorption of flavonoids from Abelmoschus manihot extract by in situ intestinal perfusion [J]. Acta Pharm Sin, 2011, 46: 454-459.
    • (2011) Acta Pharm Sin , vol.46 , pp. 454-459
    • Xue, C.F.1    Guo, J.M.2    Qian, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.