Pharmacokinetic effects of bariatric surgery;Efectos Farmacocinéticos de la Cirugía Bariátrica

Annals of Pharmacotherapy

Volumn 46, Issue 1, 2012, Pages 130-136

  Edwards, Allan ^a   Ensom, Mary H H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Bariatric surgery; Gastric bypass; Pharmacokinetics; Stomach bypass

Indexed keywords

ALCOHOL; AMOXICILLIN; ATORVASTATIN; CAFFEINE; LEVOTHYROXINE; METFORMIN; MIDAZOLAM; MORPHINE; MYCOPHENOLIC ACID; OMEPRAZOLE; PARACETAMOL; RAPAMYCIN; SERTRALINE; TACROLIMUS; TALINOLOL; TOLBUTAMIDE;

AREA UNDER THE CURVE; BARIATRIC SURGERY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG EXPOSURE; DRUG METABOLISM; GASTROINTESTINAL TRACT; HUMAN; INCIDENCE; JEJUNOILEAL BYPASS; MAXIMUM PLASMA CONCENTRATION; OBESITY; PRIORITY JOURNAL; REVIEW; STOMACH BYPASS; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; BARIATRIC SURGERY; GASTROINTESTINAL TRACT; HUMANS; OBESITY; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 84855666566     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1Q414     Document Type: Review

References (16)

1. World Health Organization. Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/index.html (accessed 2011 Apr 8).
2. Tsoi E, Shaikh H, Robinson S, Teoh TG. Obesity in pregnancy: a major healthcare issue. Postgrad Med J 2010;86:617-23.
3. American Society for Metabolic and Bariatric Surgery. Fact sheet. http://www.asmbs.org/Newsite07/media/ASMBS_Metabolic_Bariatric_Surgery_Overview_FINAL_09.pdf (accessed 2011 Apr 8).
4. Miller AD, Smith KM. Medication and nutrient administration considerations after bariatric surgery. Am J Health Syst Pharm 2006;63:1852-7.
5. Skottheim IB, Stormark K, Christensen H, et al. Significantly altered systemic exposure to atorvastatin acid following gastric bypass surgery in morbidly obese patients. Clin Pharmacol Ther 2009;86:311-8.
6. Skottheim IB, Jakobsen GS, Stormark K, et al. Significant increase in systemic exposure of atorvastatin after biliopancreatic diversion with duodenal switch. Clin Pharmacol Ther 2010;87:699-705.
7. Padwal RS, Gabr RQ, Sharma AM, et al. Effect of gastric bypass surgery on the absorption and bioavailability of metformin. Diabetes Care 2011;34:1295-300.
8. Roerig JL, Steffen K, Zimmerman C, Mitchell JE, Crosby RD, Cao L. Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort. Surg Obes Relat Dis. Epub 15 Dec 2010.
9. Rogers CC, Alloway RR, Alexander JW, et al. Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study. Clin Transplant 2008;22:281-91.
10. Klockhoff H, Näslund I, Jones AW. Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br J Clin Pharmacol 2002;54:587-91.
11. Lloret Linares C, Bardin C, Chanat C, et al. Oral morphine exposure in obese patients before and after bariatric surgery (abstract). Presented at: Obesity Reviews. 11th International Congress on Obesity, Stockholm, Sweden, July 11, 2010.
12. Rubio IG, Galrao AL, Santo MA, Zanini AC, Medeiros-Neto G. L-Thyroxine absorption is not affected by Roux-in-Y bariatric surgery in morbid obese patient (abstract). Presented at: Thyroid. 80th Annual Meeting of the American Thyroid Association, Palm Beach, FL, Sept 23, 2009.
13. Peters J, Oswald S, Haenisch S, et al. Influence of Roux-en-Y gastric bypass surgery on the pharmacokinetics of paracetamol, talinolol and amoxicillin in obese patients (abstract). Presented at: Drug Metabolism Reviews. 9th International ISSX Meeting, Istanbul, Turkey, September 4, 2010.
14. Oswald S, Haenisch S, Ludwig K, et al. Influence of Roux-en-Y gastric bypass surgery on the disposition of paracetamol, talinolol and amoxicillin in obese patients (abstract). Presented at: Clinical Pharmacology and Therapeutics. American Society for Clinical Pharmacology and Therapeutics, Dallas, TX, March 2, 2011.
15. Tandra S, Masters AR, Jones DR, et al. Effect of Roux-en-Y gastric bypass surgery on the metabolism of the orally administered medications (abstract). Presented at: Digestive Disease Week 2011, Chicago, IL, May5-7, 2011.
16. Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clinical Pharmacokinet 2002;41:343-70.