Administration of edaravone, a free radical scavenger, during t-PA infusion can enhance early recanalization in acute stroke patients - A preliminary study

Journal of the Neurological Sciences

Volumn 313, Issue 1-2, 2012, Pages 132-136

  Kimura, Kazumi ^a   Aoki, Juya ^a   Sakamoto, Yuki ^a   Kobayashi, Kazuto ^a   Sakai, Kenichi ^a   Inoue, Takeshi ^a   Iguchi, Yasuyuki ^a   Shibazaki, Kensaku ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Edaravone; MRA; Recanalization; Tissue plasminogen activator

Indexed keywords

NORPHENAZONE; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BRAIN HEMORRHAGE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; MULTICENTER STUDY; NEUROMONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECANALIZATION; SINGLE BLIND PROCEDURE; STROKE;

AGED; AGED, 80 AND OVER; ANTIPYRINE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; SINGLE-BLIND METHOD; STROKE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84855573081     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.09.006     Document Type: Article

References (27)

1. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA stroke study group N Engl J Med 333 1995 1581 1587
2. G.J. del Zoppo, K. Poeck, M.S. Pessin, S.M. Wolpert, A.J. Furlan, and A. Ferbert Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke Ann Neurol 32 1992 78 86
3. R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabin, M. Ribo, J. Munuera, and M. Rubiera Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke Stroke 38 2007 955 960 (Pubitemid 46568458)
4. Y.S. Kim, Z. Garami, R. Mikulik, C.A. Molina, and A.V. Alexandrov Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion Stroke 36 2005 869 871
5. C.A. Molina, A.V. Alexandrov, A.M. Demchuk, M. Saqqur, K. Uchino, and J. Alvarez-Sabin Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator Stroke 35 2004 151 156 (Pubitemid 38057610)
6. M. Rubiera, J. Alvarez-Sabin, M. Ribo, J. Montaner, E. Santamarina, and J.F. Arenillas Predictors of early arterial reocclusion after tissue plasminogen activator-induced recanalization in acute ischemic stroke Stroke 36 2005 1452 1456 (Pubitemid 40967511)
7. A. Zangerle, S. Kiechl, M. Spiegel, M. Furtner, M. Knoflach, and P. Werner Recanalization after thrombolysis in stroke patients: predictors and prognostic implications Neurology 68 2007 39 44 (Pubitemid 46058549)
8. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters Cerebrovasc Dis 15 2003 222 229
9. J.J. Emeis Regulation of the acute release of tissue-type plasminogen activator from the endothelium by coagulation activation products Ann N Y Acad Sci 667 1992 249 258 (Pubitemid 23061588)
10. T. Yamashita, T. Kamiya, K. Deguchi, T. Inaba, H. Zhang, and J. Shang Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain J Cereb Blood Flow Metab 29 2009 715 725
11. T. Watanabe, I. Morita, H. Nishi, and S. Murota Preventive effect of MCI-186 on 15-hpete induced vascular endothelial cell injury in vitro Prostaglandins Leukot Essent Fatty Acids 33 1988 81 87
12. T. Yamaguchi, E. Mori, K. Minematsu, J. Nakagawara, K. Hashi, and I. Saito Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT) Stroke 37 2006 1810 1815 (Pubitemid 44297734)
13. P.A. Barber, M.D. Hill, M. Eliasziw, A.M. Demchuk, J.H. Pexman, and M.E. Hudon Imaging of the brain in acute ischaemic stroke: comparison of computed tomography and magnetic resonance diffusion-weighted imaging J Neurol Neurosurg Psychiatry 76 2005 1528 1533 (Pubitemid 41531700)
14. K. Kimura, Y. Iguchi, K. Shibazaki, M. Watanabe, T. Iwanaga, and J. Aoki M1 susceptibility vessel sign on T2* as a strong predictor for no early recanalization after iv-t-PA in acute ischemic stroke Stroke 40 2009 3130 3132
15. A.M. Demchuk, R.A. Felburg, and A.V. Alexandrov Clinical recovery from acute ischemic stroke after early reperfusion of the brain with intravenous thrombolysis N Engl J Med 340 1999 894 895 (Pubitemid 29142641)
16. M.A. Albanese, W.R. Clarke, H.P. Adams Jr., and R.F. Woolson Ensuring reliability of outcome measures in multicenter clinical trials of treatments for acute ischemic stroke. The program developed for the Trial of Org 10172 in Acute Stroke Treatment (TOAST) Stroke 25 1994 1746 1751 (Pubitemid 24274965)
17. Y. Shinohara, I. Saito, S. Kobayashi, and S. Uchiyama Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial) Cerebrovasc Dis 27 2009 485 492
18. K. Abe, S. Yuki, and K. Kogure Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger Stroke 19 1988 480 485
19. H. Kawai, H. Nakai, M. Suga, S. Yuki, T. Watanabe, and K.I. Saito Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model J Pharmacol Exp Ther 281 1997 921 927 (Pubitemid 27203828)
20. A. Mizuno, K. Umemura, and M. Nakashima Inhibitory effect of MCI-186, a free radical scavenger, on cerebral ischemia following rat middle cerebral artery occlusion Gen Pharmacol 30 1998 575 578 (Pubitemid 28102837)
21. H. Nishi, T. Watanabe, H. Sakurai, S. Yuki, and A. Ishibashi Effect of MCI-186 on brain edema in rats Stroke 20 1989 1236 1240 (Pubitemid 19226920)
22. T. Yamamoto, S. Yuki, T. Watanabe, M. Mitsuka, K.I. Saito, and K. Kogure Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia Brain Res 762 1997 240 242 (Pubitemid 27315958)
23. M. Uno, K.T. Kitazato, A. Suzue, K. Matsuzaki, M. Harada, and H. Itabe Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction Free Radic Biol Med 39 2005 1109 1116 (Pubitemid 41356601)
24. K. Yagi, K.T. Kitazato, M. Uno, Y. Tada, T. Kinouchi, and K. Shimada Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator Stroke 40 2009 626 631
25. J. Nakagawara, K. Minematsu, Y. Okada, N. Tanahashi, S. Nagahiro, E. Mori, Y. Shinohara, and T. Yamaguchi Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: The Japan post-Marketing Alteplase Registration Study (J-MARS) Stroke 41 2010 1984 1989
26. E. Mori, K. Minematsu, J. Nakagawara, T. Yamaguchi, M. Sasaki, and T. Hirano Effects of 0.6 mg/kg intravenous alteplase on vascular and clinical outcomes in middle cerebral artery occlusion: Japan Alteplase Clinical Trial II (J-ACT II) Stroke 41 2010 461 465
27. G. Furst, A. Saleh, F. Wenserski, J. Malms, M. Cohnen, and A. Aulich Reliability and validity of noninvasive imaging of internal carotid artery pseudo-occlusion Stroke 30 1999 1444 1449 (Pubitemid 29296075)