Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and reperfusion

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 378-383

  Karlsson, Lars O ^a   Bergh, Niklas ^a   Li, Lizhen ^a   Bissessar, Erik ^b   Bobrova, Irina ^b   Gross, Garrett J ^c   Akyürek, Levent M ^d   Grip, Lars ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Eribis Pharmaceuticals AB   (Sweden)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Myocardial ischemia; Opioid receptors; Porcine; Reperfusion injury

Indexed keywords

DELTA OPIATE RECEPTOR; ENKEPHALIN DERIVATIVE; ERIBIS PEPTIDE 94; KAPPA OPIATE RECEPTOR; MESSENGER RNA; MU OPIATE RECEPTOR; OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SWINE; UPREGULATION;

ANIMALS; ARRHYTHMIAS, CARDIAC; CARDIOTONIC AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALINS; FEMALE; GENE EXPRESSION REGULATION; HEMODYNAMICS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RECEPTORS, OPIOID; RISK; RNA, MESSENGER; SWINE;

EID: 84855532329     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.012     Document Type: Article

References (26)

1. Barron, B.A., 1999. Opioid peptides and the heart. Cardiovasc. Res. 43, 13-16.
2. Barron, B.A., 2000. Cardiac opioids. Proc. Soc. Exp. Biol. Med. 224, 1-7.
3. Bell, S.P., Sack,M.N., Patel, A., Opie, L.H., Yellon, D.M., 2000. Delta opioid receptor stimulation mimics ischemic preconditioning in human heartmuscle. J. Am. Coll. Cardiol. 36, 2296-2302.
4. Bolling, S.F., Tramontini, N.L., Kilgore, K.S., Su, T.P., Oeltgen, P.R., Harlow, H.H., 1997. Use of "natural" hibernation induction triggers for myocardial protection. Ann. Thorac. Surg. 64, 623-627.
5. Cao, Z., Liu, L., VanWinkle, D.M., 2005. Met5-enkephalin-induced cardioprotection occurs via transactivation of EGFR and activation of PI3K. Am. J. Physiol. Heart Circ. Physiol. 288, H1955-H1964. (Pubitemid 40418026)
6. Ela, C., Barg, J., Vogel, Z., Hasin, Y., Eilam, Y., 1997. Distinct components ofmorphine effects on cardiacmyocytes aremediated by the kappa and delta opioid receptors. J.Mol. Cell. Cardiol. 29, 711-720. (Pubitemid 27192877)
7. Forster, K., Kuno, A., Solenkova, N., Felix, S.B., Krieg, T., 2007. The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation. Am. J. Physiol. Heart Circ. Physiol. 293, H1604-H1608. (Pubitemid 47367206)
8. Gross, E.R., Gross, G.J., 2006. Ligand triggers of classical preconditioning and postconditioning. Cardiovasc. Res. 70, 212-221.
9. Gross, G.J., Peart, J.N., 2007. Opioids and myocardial reperfusion injury. Arch. Mal. Coeur Vaiss. 100, 231-237. (Pubitemid 46648954)
10. Gross, E.R., Hsu, A.K., Gross, G.J., 2004. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ. Res. 94, 960-966. (Pubitemid 38490074)
11. Gross, E.R., Peart, J.N., Hsu, A.K., Auchampach, J.A., Gross, G.J., 2005. Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway. Am. J. Physiol. Heart Circ. Physiol. 288, H2744-H2749. (Pubitemid 40720653)
12. Jin-Cheng, L., Wen, Y., Zhao, Y., Quan-Yu, Z., Shu-Miao, Z., Hai-Tao, G., Hui, B., Yue-Min, W., Xin, S., Liang, C., Qin, C., Shi-Qiang, Y., Kaye, A.D., Ding-Hua, Y., Jian-Ming, P., 2008. Anti-arrhythmic effects of kappa-opioid receptor and its changes in ischemia and reperfusion. Arch. Med. Res. 39, 483-488.
13. Karlsson, L.O., Grip, L., Bissessar, E., Bobrova, I., Gustafsson, T., Kavianipour, M., Odenstedt, J.,Wikstrom, G., Gonon, A.T., 2011. Opioid receptor agonist Eribis peptide 94 reduces infarct size in different porcinemodels for myocardial ischaemia and reperfusion. Eur. J. Pharmacol. 651, 146-151.
14. Krumins, S.A., Faden, A.I., Feuerstein, G., 1985. Opiate binding in rat hearts: modulation of binding after hemorrhagic shock. Biochem. Biophys. Res. Commun. 127, 120-128. (Pubitemid 15146940)
15. Martin, W.R., 1983. Pharmacology of opioids. Pharmacol. Rev. 35, 283-323. (Pubitemid 14163214)
16. Peart, J.N., Gross, E.R., Gross, G.J., 2005. Opioid-induced preconditioning: recent advances and future perspectives. Vascul. Pharmacol. 42, 211-218. (Pubitemid 40726324)
17. Pugsley, M.K., 2002. The diverse molecular mechanisms responsible for the actions of opioids on the cardiovascular system. Pharmacol. Ther. 93, 51-75. (Pubitemid 34246441)
18. Rasakham, K., Liu-Chen, L.Y., 2011. Sex differences in kappa opioid pharmacology. Life Sci. 88, 2-16.
19. Saeed, R.W., Stefano, G.B., Murga, J.D., Short, T.W., Qi, F., Bilfinger, T.V., Magazine, H.I., 2000. Expression of functional delta opioid receptors in vascular smooth muscle. Int. J. Mol. Med. 6, 673-677.
20. Sigg, D.C., Coles Jr., J.A., Gallagher, W.J., Oeltgen, P.R., Iaizzo, P.A., 2001. Opioid preconditioning: myocardial function and energy metabolism. Ann. Thorac. Surg. 72, 1576-1582. (Pubitemid 33049766)
21. Ventura, C., Bastagli, L., Bernardi, P., Caldarera, C.M., Guarnieri, C., 1989. Opioid receptors in rat cardiac sarcolemma: effect of phenylephrine and isoproterenol. Biochim. Biophys. Acta 987, 69-74. (Pubitemid 20008999)
22. Villemagne, P.S., Dannals, R.F., Ravert, H.T., Frost, J.J., 2002. PET imaging of human cardiac opioid receptors. Eur. J. Nucl. Med. Mol. Imaging 29, 1385-1388. (Pubitemid 44392222)
23. Wittert, G., Hope, P., Pyle, D., 1996. Tissue distribution of opioid receptor gene expression in the rat. Biochem. Biophys. Res. Commun. 218, 877-881. (Pubitemid 26050757)
24. Zhou, X., Tian, F., Sandzen, J., Cao, R., Flaberg, E., Szekely, L., Cao, Y., Ohlsson, C., Bergo, M.O., Boren, J., Akyurek, L.M., 2007. Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc. Natl. Acad. Sci. U.S.A. 104, 3919-3924. (Pubitemid 47181554)
25. Zhou, A.X., Toylu, A., Nallapalli, R.K., Nilsson, G., Atabey, N., Heldin, C.H., Boren, J., Bergo, M.O., Akyurek, L.M., 2011. Filamin a mediates HGF/c-MET signaling in tumor cell migration. Int. J. Cancer 128, 839-846.
26. Zimlichman, R., Gefel, D., Eliahou, H., Matas, Z., Rosen, B., Gass, S., Ela, C., Eilam, Y., Vogel, Z., Barg, J., 1996. Expression of opioid receptors during heart ontogeny in normotensive and hypertensive rats. Circulation 93, 1020-1025. (Pubitemid 26074838)