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Volumn 4, Issue 2, 2010, Pages 150-158

Statin Pharmacogenomics: Lipid Response and Cardiovascular Outcomes

Author keywords

Cardiovascular disease; Pharmacogenetics; Pharmacogenomics; Statins

Indexed keywords


EID: 84855531506     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-010-0081-0     Document Type: Review
Times cited : (3)

References (48)
  • 1
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Published erratum appears in Lancet 2005, 366:1358 and Lancet 2008, 371:2084
    • Baigent C, Keech A, Kearney PM, et al.: Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 2005, 366: 1267-1278. (Published erratum appears in Lancet 2005, 366: 1358 and Lancet 2008, 371: 2084.).
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 2
    • 62649086172 scopus 로고    scopus 로고
    • The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis
    • Blum A, Shamburek R: The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis. Atherosclerosis 2009, 203: 325-330.
    • (2009) Atherosclerosis , vol.203 , pp. 325-330
    • Blum, A.1    Shamburek, R.2
  • 3
    • 33746799030 scopus 로고    scopus 로고
    • Clinical implications of pharmacogenomics of statin treatment
    • Mangravite LM, Thorn CF, Krauss RM: Clinical implications of pharmacogenomics of statin treatment. Pharmacogenomics J 2006, 6: 360-374.
    • (2006) Pharmacogenomics J , vol.6 , pp. 360-374
    • Mangravite, L.M.1    Thorn, C.F.2    Krauss, R.M.3
  • 5
    • 55449097874 scopus 로고    scopus 로고
    • Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease
    • This is a recent review on apoE function and pharmacogenomics
    • • Nieminen T, Kähönen M, Viiri LE, et al.: Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease. Pharmacogenomics 2008, 9: 1475-1486. This is a recent review on apoE function and pharmacogenomics.
    • (2008) Pharmacogenomics , vol.19 , pp. 1475-1486
    • Nieminen, T.1    Kähönen, M.2    Viiri, L.E.3
  • 6
    • 8644269701 scopus 로고    scopus 로고
    • Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management
    • Kajinami K, Takekoshi N, Brousseau ME, Schaefer EJ: Pharmacogenetics of HMG-CoA reductase inhibitors: exploring the potential for genotype-based individualization of coronary heart disease management. Atherosclerosis 2004, 177: 219-234.
    • (2004) Atherosclerosis , vol.177 , pp. 219-234
    • Kajinami, K.1    Takekoshi, N.2    Brousseau, M.E.3    Schaefer, E.J.4
  • 7
    • 49949088790 scopus 로고    scopus 로고
    • Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER
    • This is a recent article regarding the genes LDLR and HMGCR within the PROSPER study. It is the first LDLR study with disease end points
    • • Polisecki E, Muallem H, Maeda N, et al.: Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER. Atherosclerosis 2008, 200: 109-114. This is a recent article regarding the genes LDLR and HMGCR within the PROSPER study. It is the first LDLR study with disease end points.
    • (2008) Atherosclerosis , vol.200 , pp. 109-114
    • Polisecki, E.1    Muallem, H.2    Maeda, N.3
  • 8
    • 0023878396 scopus 로고
    • Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism
    • Boerwinkle E, Utermann G: Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism. Am J Hum Genet 1988, 42: 104-112.
    • (1988) Am J Hum Genet , vol.42 , pp. 104-112
    • Boerwinkle, E.1    Utermann, G.2
  • 9
    • 0023393613 scopus 로고
    • Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype
    • Kesäniemi YA, Ehnholm C, Miettinen TA: Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype. J Clin Invest 1987, 80: 578-581.
    • (1987) J Clin Invest , vol.80 , pp. 578-581
    • Kesäniemi, Y.A.1    Ehnholm, C.2    Miettinen, T.A.3
  • 10
    • 34548736492 scopus 로고    scopus 로고
    • Association of apolipoprotein E genotypes with lipid levels and coronary risk
    • Bennet AM, Di Angelantonio E, Ye Z, et al.: Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 2007, 298: 1300-1311.
    • (2007) Jama , vol.298 , pp. 1300-1311
    • Bennet, A.M.1    Di Angelantonio, E.2    Ye, Z.3
  • 11
    • 48349102185 scopus 로고    scopus 로고
    • Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis
    • Abboud S, Viiri LE, Lutjohann D, et al.: Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis. Eur J Hum Genet 2008, 16: 955-960.
    • (2008) Eur J Hum Genet , vol.16 , pp. 955-960
    • Abboud, S.1    Viiri, L.E.2    Lutjohann, D.3
  • 12
    • 0033543116 scopus 로고    scopus 로고
    • Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study
    • Ilveskoski E, Perola M, Lehtimäki T, et al.: Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study. Circulation 1999, 100: 608-613.
    • (1999) Circulation , vol.100 , pp. 608-613
    • Ilveskoski, E.1    Perola, M.2    Lehtimäki, T.3
  • 13
    • 33646545683 scopus 로고    scopus 로고
    • The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness
    • Nieminen T, Kähönen M, Lehtimäki T: The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness. Future Cardiol 2006, 2: 179-186.
    • (2006) Future Cardiol , vol.2 , pp. 179-186
    • Nieminen, T.1    Kähönen, M.2    Lehtimäki, T.3
  • 14
  • 15
    • 69849094785 scopus 로고    scopus 로고
    • Identification of genetic variants associated with response to statin therapy
    • Mega JL, Morrow DA, Brown A, et al.: Identification of genetic variants associated with response to statin therapy. Arterioscler Thromb Vasc Biol 2009, 29: 1310-1315.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1310-1315
    • Mega, J.L.1    Morrow, D.A.2    Brown, A.3
  • 16
    • 40549130372 scopus 로고    scopus 로고
    • Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study
    • Donnelly LA, Palmer CN, Whitley AL, et al.: Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study. Pharmacogenet Genomics 2008, 18: 279-287.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 279-287
    • Donnelly, L.A.1    Palmer, C.N.2    Whitley, A.L.3
  • 17
    • 0034724089 scopus 로고    scopus 로고
    • The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study
    • Gerdes LU, Gerdes C, Kervinen K, et al.: The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study. Circulation 2000, 101: 1366-1371.
    • (2000) Circulation , vol.101 , pp. 1366-1371
    • Gerdes, L.U.1    Gerdes, C.2    Kervinen, K.3
  • 18
    • 12244296189 scopus 로고    scopus 로고
    • The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype
    • Maitland-van der Zee AH, Stricker BH, Klungel OH, et al.: The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype. Pharmacogenetics 2002, 12: 647-653.
    • (2002) Pharmacogenetics , vol.12 , pp. 647-653
    • Maitland-van der Zee, A.H.1    Stricker, B.H.2    Klungel, O.H.3
  • 19
    • 33745747548 scopus 로고    scopus 로고
    • Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS)
    • Maitland-van der Zee AH, Jukema JW, Zwinderman AH, et al.: Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS). Acta Cardiol 2006, 61: 327-331.
    • (2006) Acta Cardiol , vol.61 , pp. 327-331
    • Maitland-van der Zee, A.H.1    Jukema, J.W.2    Zwinderman, A.H.3
  • 20
    • 35348847274 scopus 로고    scopus 로고
    • Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study
    • Chiodini BD, Franzosi MG, Barlera S, et al.: Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study. Eur Heart J 2007, 28: 1977-1983.
    • (2007) Eur Heart J , vol.28 , pp. 1977-1983
    • Chiodini, B.D.1    Franzosi, M.G.2    Barlera, S.3
  • 21
    • 0034061148 scopus 로고    scopus 로고
    • Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study
    • Ordovas JM, Cupples LA, Corella D, et al.: Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol 2000, 20: 1323-1329.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1323-1329
    • Ordovas, J.M.1    Cupples, L.A.2    Corella, D.3
  • 22
    • 45349105911 scopus 로고    scopus 로고
    • Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
    • Thompson A, Di Angelantonio E, Sarwar N, et al.: Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA 2008, 299: 2777-2788.
    • (2008) Jama , vol.299 , pp. 2777-2788
    • Thompson, A.1    Di Angelantonio, E.2    Sarwar, N.3
  • 23
    • 19944431793 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13, 677 subjects
    • Boekholdt SM, Sacks FM, Jukema JW, et al.: Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13, 677 subjects. Circulation 2005, 111: 278-287.
    • (2005) Circulation , vol.111 , pp. 278-287
    • Boekholdt, S.M.1    Sacks, F.M.2    Jukema, J.W.3
  • 24
    • 56449118071 scopus 로고    scopus 로고
    • CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction
    • Regieli JJ, Jukema JW, Grobbee DE, et al.: CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction. Eur Heart J 2008, 29: 2792-2799.
    • (2008) Eur Heart J , vol.29 , pp. 2792-2799
    • Regieli, J.J.1    Jukema, J.W.2    Grobbee, D.E.3
  • 25
    • 33745913001 scopus 로고    scopus 로고
    • Plasma cholesteryl ester transfer protein concentrations predict cardiovascular events in patients with coronary artery disease treated with pravastatin
    • Marschang P, Sandhofer A, Ritsch A, et al.: Plasma cholesteryl ester transfer protein concentrations predict cardiovascular events in patients with coronary artery disease treated with pravastatin. J Intern Med 2006, 260: 151-159.
    • (2006) J Intern Med , vol.260 , pp. 151-159
    • Marschang, P.1    Sandhofer, A.2    Ritsch, A.3
  • 26
    • 21744456077 scopus 로고    scopus 로고
    • TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia
    • Mohrschladt MF, van der Sman-de Beer F, Hofman MK, et al.: TaqIB polymorphism in CETP gene: the influence on incidence of cardiovascular disease in statin-treated patients with familial hypercholesterolemia. Eur J Hum Genet 2005, 13: 877-882.
    • (2005) Eur J Hum Genet , vol.13 , pp. 877-882
    • Mohrschladt, M.F.1    van der Sman-de Beer, F.2    Hofman, M.K.3
  • 27
    • 38349118892 scopus 로고    scopus 로고
    • Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    • This article gives the KIF6 results from the CARE and WOSCOPS studies
    • •• Iakoubova OA, Tong CH, Rowland CM, et al.: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol 2008, 51: 435-443. This article gives the KIF6 results from the CARE and WOSCOPS studies.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 435-443
    • Iakoubova, O.A.1    Tong, C.H.2    Rowland, C.M.3
  • 28
    • 38349171836 scopus 로고    scopus 로고
    • Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study
    • This article gives the KIF6 results from the PROVE-IT TIMI 22 study
    • •• Iakoubova OA, Sabatine MS, Rowland CM, et al.: Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol 2008, 51: 449-455. This article gives the KIF6 results from the PROVE-IT TIMI 22 study.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 449-455
    • Iakoubova, O.A.1    Sabatine, M.S.2    Rowland, C.M.3
  • 29
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P: Inflammation in atherosclerosis. Nature 2002, 420: 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 30
    • 2442681602 scopus 로고    scopus 로고
    • Proteoglycans in atherosclerosis and restenosis: key roles for versican
    • Wight TN, Merrilees MJ: Proteoglycans in atherosclerosis and restenosis: key roles for versican. Circ Res 2004, 94: 1158-1167.
    • (2004) Circ Res , vol.94 , pp. 1158-1167
    • Wight, T.N.1    Merrilees, M.J.2
  • 31
    • 40749099845 scopus 로고    scopus 로고
    • Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy
    • Matrix metalloproteinase gene variation was linked to coronary events in CARE and WOSCOPS and pravastatin was particularly beneficial in the high-risk group
    • •• Sabatine MS, Ploughman L, Simonsen KL, et al.: Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy. Arterioscler Thromb Vasc Biol 2008, 28: 562-567. Matrix metalloproteinase gene variation was linked to coronary events in CARE and WOSCOPS and pravastatin was particularly beneficial in the high-risk group.
    • (2008) Arterioscler Thromb Vasc Biol , vol.8 , pp. 562-567
    • Sabatine, M.S.1    Ploughman, L.2    Simonsen, K.L.3
  • 32
    • 33847288267 scopus 로고    scopus 로고
    • Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts
    • Goodarzi MO, Taylor KD, Scheuner MT, et al.: Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts. Pharmacogenomics J 2007, 7: 66-73.
    • (2007) Pharmacogenomics J , vol.7 , pp. 66-73
    • Goodarzi, M.O.1    Taylor, K.D.2    Scheuner, M.T.3
  • 33
    • 34548442912 scopus 로고    scopus 로고
    • Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients
    • Singer JB, Holdaas H, Jardine AG, et al.: Genetic analysis of fluvastatin response and dyslipidemia in renal transplant recipients. J Lipid Res 2007, 48: 2072-2078.
    • (2007) J Lipid Res , vol.48 , pp. 2072-2078
    • Singer, J.B.1    Holdaas, H.2    Jardine, A.G.3
  • 34
    • 57149124098 scopus 로고    scopus 로고
    • A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study
    • Donnelly LA, Doney AS, Dannfald J, et al.: A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study. Pharmacogenet Genomics 2008, 18: 1021-1026.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 1021-1026
    • Donnelly, L.A.1    Doney, A.S.2    Dannfald, J.3
  • 35
    • 41149174566 scopus 로고    scopus 로고
    • Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment
    • Krauss RM, Mangravite LM, Smith JD, et al.: Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment. Circulation 2008, 117: 1537-1544.
    • (2008) Circulation , vol.117 , pp. 1537-1544
    • Krauss, R.M.1    Mangravite, L.M.2    Smith, J.D.3
  • 36
    • 10744223821 scopus 로고    scopus 로고
    • Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men
    • Lehtimäki T, Laaksonen R, Janatuinen T, et al.: Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men. Pharmacogenetics 2003, 13: 633-639.
    • (2003) Pharmacogenetics , vol.13 , pp. 633-639
    • Lehtimäki, T.1    Laaksonen, R.2    Janatuinen, T.3
  • 37
    • 0036460053 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study
    • Kunnas TA, Lehtimäki T, Laaksonen R, et al.: Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study. J Mol Med 2002, 80: 802-807.
    • (2002) J Mol Med , vol.80 , pp. 802-807
    • Kunnas, T.A.1    Lehtimäki, T.2    Laaksonen, R.3
  • 38
    • 34547113361 scopus 로고    scopus 로고
    • Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy
    • Nieminen T, Knuuti J, Hämelahti P, et al.: Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy. Vascul Pharmacol 2007, 47: 113-117.
    • (2007) Vascul Pharmacol , vol.47 , pp. 113-117
    • Nieminen, T.1    Knuuti, J.2    Hämelahti, P.3
  • 39
    • 10744232085 scopus 로고    scopus 로고
    • Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men
    • Maitland-van der Zee AH, Klungel OH, Stricker BH, et al.: Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men. Pharmacogenetics 2004, 14: 53-60.
    • (2004) Pharmacogenetics , vol.14 , pp. 53-60
    • Maitland-van der Zee, A.H.1    Klungel, O.H.2    Stricker, B.H.3
  • 40
    • 54949084597 scopus 로고    scopus 로고
    • A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle
    • Laaksonen R, Katajamaa M, Paiva H, et al.: A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One 2006, 1: e97.
    • (2006) PLoS One , vol.1
    • Laaksonen, R.1    Katajamaa, M.2    Paiva, H.3
  • 41
    • 67149122437 scopus 로고    scopus 로고
    • The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13) on the effectiveness of statins: the GenHAT study
    • Maitland-van der Zee AH, Peters BJ, Lynch AI, et al.: The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13) on the effectiveness of statins: the GenHAT study. Pharmacogenet Genomics 2009, 19: 338-344.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 338-344
    • Maitland-van der Zee, A.H.1    Peters, B.J.2    Lynch, A.I.3
  • 42
    • 49949100564 scopus 로고    scopus 로고
    • Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    • Polisecki E, Peter I, Robertson M, et al.: Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis 2008, 200: 95-101.
    • (2008) Atherosclerosis , vol.200 , pp. 95-101
    • Polisecki, E.1    Peter, I.2    Robertson, M.3
  • 43
    • 33845299191 scopus 로고    scopus 로고
    • Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study
    • Maitland-van der Zee AH, Boerwinkle E, Arnett DK, et al.: Absence of an interaction between the angiotensin-converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Am Heart J 2007, 153: 54-58.
    • (2007) Am Heart J , vol.153 , pp. 54-58
    • Maitland-van der Zee, A.H.1    Boerwinkle, E.2    Arnett, D.K.3
  • 44
    • 55749089900 scopus 로고    scopus 로고
    • Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study
    • Maitland-van der Zee AH, Lynch A, Boerwinkle E, et al.: Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C> T, MTHFR 1298 A> C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study. Pharmacogenet Genomics 2008, 18: 651-656.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 651-656
    • Maitland-van der Zee, A.H.1    Lynch, A.2    Boerwinkle, E.3
  • 45
    • 55749100167 scopus 로고    scopus 로고
    • Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke
    • Hindorff LA, Lemaitre RN, Smith NL, et al.: Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke. Pharmacogenet Genomics 2008, 18: 677-682.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 677-682
    • Hindorff, L.A.1    Lemaitre, R.N.2    Smith, N.L.3
  • 46
    • 34249667780 scopus 로고    scopus 로고
    • Lectin-like oxidized-LDL receptor-1 (LOX-1) polymorphisms influence cardiovascular events rate during statin treatment
    • Puccetti L, Pasqui AL, Bruni F, et al.: Lectin-like oxidized-LDL receptor-1 (LOX-1) polymorphisms influence cardiovascular events rate during statin treatment. Int J Cardiol 2007, 119: 41-47.
    • (2007) Int J Cardiol , vol.119 , pp. 41-47
    • Puccetti, L.1    Pasqui, A.L.2    Bruni, F.3
  • 47
    • 37349021357 scopus 로고    scopus 로고
    • Genetic influence in antithrombotic actions of atorvastatin in hypercholesterolaemia
    • Puccetti L, Bruni F, Pasqui AL, et al.: Genetic influence in antithrombotic actions of atorvastatin in hypercholesterolaemia. Eur J Clin Invest 2008, 38: 11-16.
    • (2008) Eur J Clin Invest , vol.38 , pp. 11-16
    • Puccetti, L.1    Bruni, F.2    Pasqui, A.L.3
  • 48
    • 55449085527 scopus 로고    scopus 로고
    • Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy
    • Couvert P, Giral P, Dejager S, et al.: Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy. Pharmacogenomics 2008, 9: 1217-1227.
    • (2008) Pharmacogenomics , vol.9 , pp. 1217-1227
    • Couvert, P.1    Giral, P.2    Dejager, S.3


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