Protective effect of ethanolic extract and its ethylacetate and n-butanol fractions of sechium edule fruits against carbon tetrachloride induced hepatic injury in rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue 1, 2012, Pages 354-359

  Firdous, S M ^a   Sravanthi, K ^a   Debnath, R ^a   Neeraja, K ^a  

^a Calcutta Institute of Pharmaceutical Technology and AHS   (India)

Author keywords

Antioxidative; CCl 4; Hepatoprotective activity; Hepatotoxicity; Sechium edule

Indexed keywords

ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BUTANOL; CARBOHYDRATE; CARBON TETRACHLORIDE; CATALASE; CREATININE; FLAVONOID; GLUTATHIONE; LIVER PROTECTIVE AGENT; MALONALDEHYDE; PLANT EXTRACT; PLANT GLYCOSIDE; PROTEIN; SAPONIN; SECHIUM EDULE PLANT EXTRACT; SUPEROXIDE DISMUTASE; TANNIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL PROTECTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG SCREENING; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FRUIT; HISTOPATHOLOGY; LD 50; LIPID PEROXIDATION; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MEDICINAL PLANT; NONHUMAN; PHYTOCHEMISTRY; PROTEIN BLOOD LEVEL; RAT; SECHIUM EDULE; SINGLE DRUG DOSE; TOXICITY TESTING;

EID: 84855488893     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Rafel lira saade. CHAYOTE, sechium edule (jacq), IPGRI 1996: 28-9.
2. Kim S. Sechium edule (jacq). Oct 2009 [cited on 11 Dec 2009]. Available at URL: http://en.wikipedia.org/wiki/Chayote.
3. Vozari-Hampe MM, Viegas C, Saucedo C, Rosseto S, Manica GG, Hampe OG. A lectin from Sechium edule fruit exudates. Phytochemistry 1992 May 1; 31(5): 1477-80.
4. Siciliano T, De Tommasi N. Study of Flavonoids of Sechium edule (Jacq) swartz (Cucurbitaceae) different edible organs by liquid chromatography photodiode array mass spectrometry. J Agric Food Chem 2004; 52 (21):6510-15.
5. Albone KS, Gaskin P, MacMillan J, Sponsel VM. Identification and localization of gibberlins in maturing seed of cucurbit sechium edule, and a comparison between this cucurbit and the legume Phaseolus coccineus. Planta springer-verla 1984; 162: 560-65.
6. Kamble MB, Dumbre RK, Rangari VD. Hepatoprotective activity studies of herbal formulations. Int J Green Pharm 2008; 2:147-51.
7. Gordon EA, Guppy LJ, Nelson M. The antihypertensive effects of the Jamaican Cho- Cho (Sechium edule). West Ind Med J 2000; 49(1): 27-31.
8. Ordonez AA, Gomez JD, Isla MA. Antioxidant activities of Sechium edule (Jacq.) Swartz extracts. Food Chem 2006; 97(3): 452-8.
9. Khandelwal KR. Practical Pharmacognosy. 11th ed. Nirali Prakashan, Pune. 2004. p. 149-56.
10. OECD, 2002. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals organisation for economics co-operation, development, Paris, June, 2000.
11. Sanjay J, Vinod KD, Neelzesh M, Vijay A. Antioxidant and hepatopraotective activity of ethanolic and aqueous extracts of Amorphophallus campanulatus roxb. tubers. Acta Poloniac Pharmaceutica Drug Res 2009; 66(4): 423-8.
12. Rajib A, Monirul I, Israt JB. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. Eur J Sci Res 2009; 37(2): 302-10.
13. Wilson JS, Ganesan K, Palanisamy M. Effect of sinapic acid on biochemical markers and histopathological studies in normal and streptozotocin -induced diabetes in wistar rats Int J Pharm Pharm Sci 2011; 3, suppl 4: 115-20.
14. Okhawa H, ohisini N, Yagi K. Assay for lipid peroxidation in animals tissue by thiobarbituric acid reaction, Anal Biochem 1979; 95: 351.
15. Ellman GL. Tissue sulphgahydryl groups. Arch Biochem Biophys 1959; 82: 70.
16. Kakkar P, Das B, Viswanathan PN. A modified sphectrophotometric assay of superoxide dismutase, Ind J Biochem Biophys 1984; 21: 131.
17. Hugo EB. Oxidoreductase activity on groups other than CHOH: Catalase. In: Colowick SP, Kaplan NO, Packer L ed. Methods in Enzymalogy. vol 105. Academic Press, London. 1984. p.121-25
18. Krishna KL, Mruthunjaya. Antioxidant and hepatoprotective activity of leaf extract of Justica gendrerussa. Int J Biol Chem 2009; 3(3): 99-110.
19. Bipin BP, Kzalpesh G, Nema RK, Sharma CS, Abhishek K J, Jain CP. Hepatoprotective activity of Jatropha gossypifolia against carbon tetrachloride- induced hepatic injury in rats. Asian J Pharmaceutical & Clin Res 2009; (2)1: 50-4.
20. Kaplowitz N, Aw TY, Simon FR, Stolz A. Drug induced hepatotoxicity. Ann Intern Med 1986; 104: 826.
21. Gupta M, Mazumder UK, Kumar ST, Gomathi P. Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbontetrachloride induced liver damage in rats. Iran J Pharmacol Ther 2004; 3: 12-20.
22. AL-Howiriny TA, AL-Sohaibani MO, AL-Said MS, Rafatullah S. Hepatoprotective properties of Commiphora opobalsamum (Balessan), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin Res 2004; 30 (5/6): 213-20.
23. Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J. Hepatoprotective activity of Aerva lanata Linn. against Paracetamol induced hepatotoxicity in rats. Res J Pharm & Tech 2008 Oct; 1(4): 398-400.
24. Wahid AM, Vijay RS, Satish BB. Hepatoprotective activity of hydroalcoholic extract leaves of Alocassie indica. Ind J Exp Biol 2009; 47: 816-2.
25. Firdous, Raju K, Pallab H. Evaluation of hepatoprotective activity of saponin of Momordica dioica roxb. Against CCl4 induced hepatic injury in rats. Pharmacologyonline 2008; 3: 487-94.
26. Muriel P. Peroxidation of lipids damage in antioxidants, oxidants and free radicals, Edited by S I Baskin, H Salem. Taylor and Francis, Washington DC. 1997. p 237.
27. Savides MC and Woheme F. Acteaminophen and its toxicity. J Appl Toxicol. 1983; 3: 36.
28. Meister A. New aspects of glutathione biochemistry and transport selective alterations of glutathione metabolism. Nutr Rev 1984; 42(12): 397-410.
29. Comporti M, Mellaro E, Del BB, Casini AF. Glutathione depletion, its effects on other antioxidant systems and hepatocellular damage. Xenobiotica 1991; 21: 1067.
30. Bhakta T, Pulok KM, Kakali M, Banerjee S. Evaluation of hepatoprotective activity of Cassia fistula leaf extract, J Ethnopharmacol 1999; 66: 227.
31. Karunakar H, Arun BJ, Hepatoprotective activity of Carissa carandas root extract against ccl4 and paracetamol induced hepatic oxidative stress. Ind J Exp Biol 2009; 47: 660-7.
32. Raj Narayan K, Sripal Reddy M, Krishna DR. Bioflavanoids classification, pharmacological, biochemical effects and therapeutic potential. Ind J Pharmacol 2001; 33: 2-16.
33. Nitin D, Sanjula B, Kanchana K. Silymarin: A review of pharmacological aspects and bioavailability enhancemant approaches. Ind J Pharmacol Aug 2007; 39(4): 172-9.
34. Miroljub B, Sladana P. Biologically active components of Soybeans and Soy protein products - a review. APTEFF. 2005; 36: 155-68.
35. Junei K, Masahiro H, Ryota T. Hepatoprotective constituents in plants 15: protective effects of natural-occurring flavonoids and miscellaneous phenolic compounds as determined in a HepG2 cell cytotoxicity assay. J Nat Med 2006; 6: 36-41.
36. Tiwari BK, Khosa RL. Evaluation of the hepatoprotective and antioxidant effect of berberis asiatica against experimentally induced liver injury in rats. Int J Pharm Pharm Sci 2010; 2, suppl 1: 92-7.