Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy

Cancer

Volumn 118, Issue 2, 2012, Pages 528-535

  Yin, Ming ^a   Liao, Zhongxing ^a   Liu, Zhensheng ^a   Wang, Li E ^a   O'Reilly, Michael ^a   Gomez, Daniel ^a   Li, Minghuan ^b   Komaki, Ritsuko ^a   Wei, Qingyi ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

DNA ligase4; Nonsmall cell lung cancer; Polymorphism; Radiation pneumonitis

Indexed keywords

ADENINE; CYTOSINE; GUANINE; THYMINE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CANCER RADIOTHERAPY; CASE CONTROL STUDY; CONTROLLED STUDY; DNA END JOINING REPAIR; DNA LIGASE IV GENE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; RADIATION PNEUMONIA; SINGLE NUCLEOTIDE POLYMORPHISM; X RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELL 4 GENE; X RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELL 5 GENE; X RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELL 6 GENE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NUCLEAR; CARCINOMA, NON-SMALL-CELL LUNG; DNA HELICASES; DNA LIGASES; DNA-BINDING PROTEINS; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RADIATION PNEUMONITIS; RADIOTHERAPY; RISK FACTORS;

EID: 84855485731     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26214     Document Type: Article

References (21)

1. Roach M 3rd, Gandara DR, Yuo HS, et al. Radiation pneumonitis following combined modality therapy for lung cancer: analysis of prognostic factors. J Clin Oncol. 1995;13: 2606-2612.
2. Provatopoulou X, Athanasiou E, Gounaris A. Predictive markers of radiation pneumonitis. Anticancer Res 28(4C): 2421-2432, 2008.
3. Yuan X, Liao Z, Liu Z, et al. Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy. J Clin Oncol. 2009;27:3370-3378.
4. Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res. 2001; 156(5 pt 2):577-583. (Pubitemid 33027531)
5. Ward JF. The yield of DNA double-strand breaks produced intracellularly by ionizing radiation: a review. Int J Radiat Biol. 1990;57:1141-1150. (Pubitemid 20177786)
6. Yano K, Morotomi-Yano K, Adachi N, Akiyama H. Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway. J Radiat Res (Tokyo). 2009;50:97-108.
7. Ayene IS, Ford LP, Koch CJ. Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol Cancer Ther. 2005;4:529-536. (Pubitemid 40601833)
8. Bertolini LR, Bertolini M, Anderson GB, Maga EA, Madden KR, Murray JD. Transient depletion of Ku70 and Xrcc4 by RNAi as a means to manipulate the non-homologous end-joining pathway. J Biotechnol. 2007;128:246-257. (Pubitemid 46074194)
9. Chistiakov DA, Voronova NV, Chistiakov AP. Ligase IV syndrome. Eur J Med Genet. 2009;52:373-378.
10. Wang S, Liao Z, Wei X, et al. Analysis of clinical and dosimetric factors associated with treatment-related pneumonitis (TRP) in patients with non-small-cell lung cancer (NSCLC) treated with concurrent chemotherapy and 3-dimensional conformal radiotherapy (3D-CRT). Int J Radiat Oncol Biol Phys. 2006;66:1399-1407.
11. Jin H, Tucker SL, Liu HH, et al. Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy. Radiother Oncol. 2009;91:427-432.
12. Cancer Therapy Evaluation Program (CTEP). Common Terminology Criteria for Adverse Events, version 3. Bethesda, MD: National Cancer Institute; 2003.
13. Tseng RC, Hsieh FJ, Shih CM, Hsu HS, Chen CY, Wang YC. Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study. Cancer. 2009; 115:2939-2948.
14. Hsu NY, Wang HC, Wang CH, et al. Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan. Cancer Biomarkers. 2009;5:159-165.
15. Willems P, Claes K, Baeyens A, et al. Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity. Genes Chromosomes Cancer. 2008;47:137-148.
16. Bau DT, Yang MD, Tsou YA, et al. Colorectal cancer and genetic polymorphism of DNA double-strand break repair gene XRCC4 in Taiwan. Anticancer Res. 2010;30:2727-2730.
17. Chiu CF, Tsai MH, Tseng HC, et al. A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients. Oral Oncol. 2008;44:898-902.
18. Jeggo PA. DNA breakage and repair. Adv Genet. 1998;38: 185-218.
19. Grawunder U, Zimmer D, Leiber MR. DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains. Curr Biol. 1998;8:873-876. (Pubitemid 28356047)
20. Girard PM, Kysela B, Harer CJ, Doherty AJ, Jeggo PA. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of 2 linked polymorphisms. Hum Mol Genet. 2004;13:2369-2376. (Pubitemid 39377841)
21. O'Driscoll M, Cerosaletti KM, Girard PM, et al. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol Cell. 2001;8:1175-1185. (Pubitemid 34084990)