Fighting a resistant organism with modern weapons: Biology of mycobacteria and new molecular targets;Einen widerstandsfähigen Organismus mit modernen Waffen bekämpfen: Biologie der Mykobakterien und neue molekulare Targets

Pharmazie in Unserer Zeit

Volumn 41, Issue 1, 2012, Pages 19-26

  Koch, Oliver ^a   Selzer, Paul M ^b  

^a Intervet Innovation GmbH   (Germany)

^b Molisa GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; DRUG TARGETING; MICROBIOLOGY; MYCOBACTERIUM; NONHUMAN;

ANTI-BACTERIAL AGENTS; ANTITUBERCULAR AGENTS; DRUG DISCOVERY; HUMANS; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; PEROXIDES; TUBERCULOSIS;

EID: 84855479244     PISSN: 00483664     EISSN: 16151003     Source Type: Journal    
DOI: 10.1002/pauz.201100449     Document Type: Article

References (12)

1. Madigan, M.T., Martinko, J.M.: Brock Mikrobiologie, 11. Auflage, Pearson Studium, München (2009).
2. Wang, Y.N., Chi, C.Q., Cai, M., Lou, Z.Y., Tang, Y.Q., et al., Amycolicicoccus subflavus gen. nov., sp. nov., an actinomycete isolated from a saline soil contaminated by crude oil. Int. J. Syst. Evol. Microbiol. (2010) 60, 638-643.
3. Wirth, T., Hildebrand, F., Allix-Béguec, C., Wölbeling, F., Kubica, T., et al., Origin, spread and demography of the Mycobacterium tuberculosis complex. PLoS Pathog. (2008) 19, e1000160.
4. Kazda, J., Pavlik, I., Falkinham III, J.O., Hruska, K.: The Ecology of Mycobacteria: Impact on Animal's and Human's Health, Springer, Netherlands (2009).
5. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., et al., Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 393, 537-544. (Pubitemid 28319235)
6. Dartois, V., Leong, F.J., Dick, T.: Tuberculosis Drug Discovery: Issues, Gaps and the way forward (2009). In Selzer, P. (ed): Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates. Wiley VCH Verlag, Weinheim, pp. 415-44.
7. Janin, Y.L., Antituberculosis drugs: ten years of research. Bioorg. Med. Chem. (2007) 15, 2479-2513. (Pubitemid 46367698)
8. Lamichhane, G., Novel targets in M. tuberculosis: search for new drugs. Trends Mol. Med. (2011) 17, 25-33.
9. Jaeger T.: Peroxiredoxin systems in mycobacteria. In Flohé, L., Harris, J.R. (eds): Peroxiredoxin Systems. Subcell. Biochem. 44 (2007), pp. 207-217.
10. Bryk, R., Gold, B., Venugopal, A., Singh, J., Samy, R., et al., Selective killing of nonreplicating mycobacteria. Cell Host Microbe (2008) 3, 137-145.
11. Koch, O., Doil, N., Heller, K., Stuhlmann, F., Schmitt, S., et al.: A New Player in the Fight against Tuberculosis: Thioredoxin Reductase Inhibitors with High Bioactivity on M. tuberculosis. Vortrag auf der Konferenz "Frontiers in Medicinal Chemistry", 20.-23.März 2011 in Saarbrücken.
12. Shi, W., Zhang, X., Jiang, X., Yuan, H., Lee, J.S., Barry, C.E. 3rd, Wang, H., Zhang, W., Zhang, Y., Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science (2011) 333, 1630-1632.