Complement activation on platelets correlates with a decrease in circulating immature platelets in patients with immune thrombocytopenic purpura

British Journal of Haematology

Volumn 148, Issue 4, 2010, Pages 638-645

  Peerschke, Ellinor I B ^a,b   Andemariam, Biree ^c   Yin, Wei ^a   Bussel, James B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Complement; Immune thrombocytopenic purpura; Platelet count

Indexed keywords

AZATHIOPRINE; CD40 LIGAND MONOCLONAL ANTIBODY; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C4D; DANAZOL; GMA 161; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; RHESUS D ANTIBODY; RITUXIMAB; STEROID; THROMBOPOIETIN; UNCLASSIFIED DRUG; VINCRISTINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; COMPLEMENT FIXATION; CONTROLLED STUDY; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MAJOR CLINICAL STUDY; MALE; MEGAKARYOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; TREATMENT RESPONSE;

ADOLESCENT; ADULT; AGED; BLOOD PLATELETS; CHILD; CHILD, PRESCHOOL; COMPLEMENT ACTIVATION; COMPLEMENT FIXATION TESTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PREDICTIVE VALUE OF TESTS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SENSITIVITY AND SPECIFICITY; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 75149140433     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07995.x     Document Type: Article

References (32)

1. Ault, K.A., Rinder, H.M., Mitchell, J., Carmody, M.B., Vary, C.P. Hillman, R.S. (1992) The significance of platelets with increased RNA content (reticulated platelets). A measure of the rate of thrombopoiesis. American Journal of Clinical Pathology, 98, 637 646.
2. Beardsley, D.S. Ertem, M. (1998) Platelet autoantibodies in immune thrombocytopenic purpura. Transfusion Science, 19, 237 244.
3. Briggs, C., Kunka, S., Hart, D., Oguni, S. Machin, S.J. (2004) Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia. British Journal of Haematology, 126, 93 99.
4. Cines, D.B., Bussel, J.B., Liebman, H.A. Luning Prak, E.T. (2009) The ITP syndrome: pathogenic and clinical diversity. Blood, 113, 6511.
5. Del Conde, I., Cruz, M.A., Zhang, H., Lopez, J.A. Afshar-Kharghan, V. (2005) Platelet activation leads to activation and propagation of the complement system. Journal of Experimental Medicine, 201, 871 879.
6. Forster, J., Katzikadamos, Z. Zinn, P. (1989) Platelet-associated IgG, IgM, and C3 in paediatric infectious disease. Helvetica Paediatrica Acta, 43, 415 422.
7. George, J.N., El-Harake, M.A. Aster, R.H. (1995) Thrombocytopenia due to enhanced platelet destruction by immunologic mechanisms. In : Williams Hematology, 5th edn eds by E. Beutler, M.A. Lichtman, B.S. Coller T.J. Kipps pp. 1315 1355. McGraw-Hill, New York.
8. Hamad, O.A., Ekdahl, K.N., Nilsson, P.H., Andersson, J., Magotti, P., Lambris, J.D. Nilsson, B. (2008) Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis, 6, 1413 1421.
9. He, R., Reid, D.M., Jones, C.E. Shulman, N.R. (1994) Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood, 83, 1024 1032.
10. Huber-Lang, M., Sarma, J.V., Zetoune, F.S., Rittirsch, D., Neff, T.A., McGuire, S.T., Lambris, J.D., Warner, R.L., Flierl, M.A., Hoesel, L.M., Bebhard, F., Younger, J.G., Drouin, S.M., Wetsel, R.A. Ward, P.A. (2006) Generation of C5a in the absence of C3: a new complement activation pathway. Nature Medicine, 12, 682 687.
11. Kayser, W., Mueller-Eckhardt, C., Bhakdi, S. Ebert, K. (1983) Platelet associated complement C3 in thrombocytopenic states. British Journal of Haematology, 54, 353 363.
12. Kurata, Y., Hayashi, S., Aochi, H., Nagamine, K., Oshida, M., Mizutani, H., Tomiyama, Y., Tsubakio, T., Yonezawa, T. Tarui, S. (1987) Analysis of antigen involved in circulating immune complexes in patients with idiopathic thrombocytopenic purpura. Clinical and Experimental Immunology, 67, 293 299.
13. Kuwana, M., Kaburaki, J., Kitasato, H., Kato, M., Kawai, S., Kawakami, Y. Ikeda, Y. (2001) Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura. Blood, 98, 130 139.
14. Lurhuma, A.Z., Riccomi, H. Masson, P.L. (1977) The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura. Clinical and Experimental Immunology, 28, 49 55.
15. McMillan, R. (2000) Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Seminars in Hematology, 37, 239 248. (Pubitemid 30612902)
16. Ohali, M., Maizlish, Y., Abramov, H., Schlesinger, M., Bransky, D. Lugassy, G. (2005) Complement profile in childhood immune thrombocytopenic purpura: a prospective pilot study. Annals of Hematology, 84, 812 815.
17. Panzer, S., Szamait, S., Boedeker, R.H., Haas, O.A., Haubenstock, A. Mueller-Eckhardt, C. (1986) Platelet associated immunoglobulin IgG, IgM, IgA and complement C3 in immune thrombocytopenic disorders. American Journal of Hematology, 23, 89 99.
18. Parker, C. (2009) Eculizumab for paroxysmal nocturnal hemoglobinuria. Lancet, 373, 759 767.
19. Peerschke, E.I.B., Yin, W., Grigg, S.E. Ghebrehiwet, B. (2006) Blood platelets activate the classical pathway of human complement. Journal of Thrombosis and Haemostasis, 4, 2035 2042.
20. Peerschke, E.I.B., Yin, W., Alpert, D.R., Roubey, R.A.S., Salmon, J.E. Ghebrehiwet, B. (2009) Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies. Lupus, 18, 530 538.
21. Richards, E.M. Baglin, T.P. (1995) Quantitation of reticulated platelets: methodology and clinical application. British Journal of Haematology, 91, 445 451.
22. Ricklin, D. Lambris, J.D. (2008) Compstatin: a complement inhibitor on its way to clinical application. Advances in Experimental Medicine and Biology, 632, 273 292.
23. Rinder, H.M., Munz, U.J., Ault, K.A., Bonan, J.L. Smith, B.R. (1993) Reticulated platelets in the evaluation of thrombopoietic disorders. Archives of Pathology and Laboratory Medicine, 117, 606 610.
24. Rodeghiero, F., Stasi, R., Gernsheimer, T., Michel, M., Provan, D., Arnold, D.M., Bussel, J.B., Cines, D.B., Chong, B.H., Cooper, N., Godeau, B., Lechner, K., Mazzucconi, M.G., McMillan, R., Sanz, M.A., Imbach, P., Blanchette, V., Kuehne, T., Ruggeri, M. George, J.N. (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood, 113, 2386 2393.
25. Ruiz-Delgado, G.J., Vasquez-Garza, E., Mendez-Ramirez, N. Gomez-Almaguer, D. (2009) Abnormalities in the expression of CD55 and CD59 surface molecules on peripheral blood cells are not specific to paroxysmal nocturnal hemoglobinuria. Hematology, 14, 33 37.
26. Semple, J.W., Milev, Y., Cosgrave, D., Mody, M., Hornstein, A., Blanchette, V. Freedman, J. (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood, 87, 4245 4254.
27. Shattil, S.J., Cunningham, M., Wiedmer, T., Zhao, J., Sims, P.J. Brass, L.F. (1992) Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. Journal of Biological Chemistry, 267, 18424 18431.
28. Takami, A., Shibayama, M., Orito, M., Omote, M., Okumura, H., Yamashita, T., Shimadoi, S., Yoshida, T., Nakao, S. Asakura, H. (2007) Immature platelet fraction for prediction of platelet engraftment after allogeneic stem cell transplantation. Bone Marrow Transplantation, 39, 501 507.
29. Trent, R.J., Clancy, R.L., Danis, V. Basten, A. (1980) Immune complexes in thrombocytopenic patients: cause or effect? British Journal of Haematology, 44, 645 654.
30. Venneker, G.T. Asghar, S.S. (1992) CD59: a molecule involved in antigen presentation as well as down regulation of membrane attack complex. Experimental and Clinical Immunogenetics, 9, 33 47.
31. Wiedmer, T., Esmon, C.T. Sims, P.J. (1986) Complement proteins C5b-9 stimulate procoagulant activity through prothrombinase. Blood, 68, 875 880. (Pubitemid 17183846)
32. Yin, W., Ghebrehiwet, B. Peerschke, E.I.B. (2008) Expression of complement components and inhibitors on platelet microparticles. Platelets, 19, 225 233.