Interocular suppression in strabismic amblyopia results in an attenuated and delayed hemodynamic response function in early visual cortex

Journal of Vision

Volumn 11, Issue 14, 2011, Pages 1-12

  Farivar, Reza ^a,b   Thompson, Benjamin ^c   Mansouri, Behzad ^d   Hess, Robert F ^e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY OF MANITOBA   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

Functional imaging; Hemodynamic modulation; Hemodynamic response; Visual cortex; Visual development

Indexed keywords

ADULT; AMBLYOPIA; ARTICLE; BRAIN CIRCULATION; COMPARATIVE STUDY; EYE DOMINANCE; FEMALE; HEMODYNAMICS; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; STRABISMUS; VASCULARIZATION; VISUAL CORTEX; YOUNG ADULT;

ADULT; AMBLYOPIA; CEREBROVASCULAR CIRCULATION; DOMINANCE, OCULAR; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; STRABISMUS; VISUAL CORTEX; YOUNG ADULT;

EID: 84855454805     PISSN: None     EISSN: 15347362     Source Type: Journal    
DOI: 10.1167/11.14.16     Document Type: Article

References (43)

1. Algaze, A., Roberts, C., Leguire, L., Schmalbrock, P., & Rogers, G. (2002). Functional magnetic resonance imaging as a tool for investigating amblyopia in the human visual cortex: A pilot study. Journal of the American Association for Pediatric Ophthalmology and Strabismus, 6, 300-308.
2. Anderson, S. J., & Swettenham, J. B. (2006). Neuroimaging in human amblyopia. Strabismus, 14, 21-35.
3. Baker, D. H., Meese, T. S., Mansouri, B., & Hess, R. F. (2007). Binocular summation of contrast remains intact in strabismic amblyopia. Investigative Ophthalmology & Visual Science, 48, 5332-5338.
4. Barnes, G. R., Hess, R. F., Dumoulin, S. O., Achtman, R. L., & Pike, G. B. (2001). The cortical deficit in humans with strabismic amblyopia. The Journal of Physiology, 533, 281-297.
5. Brainard, D. H. (1997). The psychophysics toolbox. Spatial Vision, 10, 433-436.
6. Choi, M. Y., Lee, K. M., Hwang, J. M., Choi, D. G., Lee, D. S., Park, K. H., et al. (2001). Comparison between anisometropic and strabismic amblyopia using functional magnetic resonance imaging. British Journal of Ophthalmology, 85, 1052-1056.
7. Conner, I. P., Odom, J. V., Schwartz, T. L., & Mendola, J. D. (2007a). Monocular activation of V1 and V2 in amblyopic adults measured with functional magnetic resonance imaging. Journal of the American Association for Pediatric Ophthalmology and Strabismus, 11, 341-350.
8. Conner, I. P., Odom, J. V., Schwartz, T. L., & Mendola, J. D. (2007b). Retinotopic maps and foveal suppression in the visual cortex of amblyopic adults. The Journal of Physiology, 583, 159-173.
9. de Belsunce, S., & Sireteanu, R. (1991). The time course of interocular suppression in normal and amblyopic subjects. Investigative Ophthalmology & Visual Science, 32, 2645-2652.
10. Friston, K. J., Fletcher, P., Josephs, O., Holmes, A., Rugg, M. D., & Turner, R. (1998). Event-related fMRI: Characterizing differential responses. Neuroimage, 7, 30-40.
11. Goodyear, B. G., Nicolle, D. A., Humphrey, G. K., & Menon, R. S. (2000). BOLD fMRI response of early visual areas to perceived contrast in human amblyopia. Journal of Neurophysiology, 84, 1907-1913.
12. Goodyear, B. G., Nicolle, D. A., & Menon, R. S. (2002). High resolution fMRI of ocular dominance columns within the visual cortex of human amblyopes. Strabismus, 10, 129-136.
13. Harrad, R., Sengpiel, F., & Blakemore, C. (1996). Physiology of suppression in strabismic amblyopia. British Journal of Ophthalmology, 80, 373-377.
14. Hess, R. F. (1979). Contrast sensitivity assessment of functional amblyopia in humans. Transactions of the Ophthalmological Societies of the United Kingdom, 99, 391-397.
15. Hess, R. F. (2001). Amblyopia: Site unseen. Clinical and Experimental Optometry, 84, 321-336.
16. Hess, R. F., & Howell, E. R. (1977). The threshold contrast sensitivity function in strabismic amblyopia: Evidence for a two type classification. Vision Research, 17, 1049-1055.
17. Hess, R. F., Li, X., Lu, G., Thompson, B., & Hansen, B. C. (2010). The contrast dependence of the cortical fMRI deficit in amblyopia; a selective loss at higher contrasts. Human Brain Mapping, 31, 1233-1248.
18. Hess, R. F., Li, X., Mansouri, B., Thompson, B., & Hansen, B. C. (2009). Selectivity as well as sensitivity loss characterizes the cortical spatial frequency deficit in amblyopia. Human Brain Mapping, 30, 4054-4069.
19. Hess, R. F., Thompson, B., Gole, G., & Mullen, K. T. (2009). Deficient responses from the lateral geniculate nucleus in humans with amblyopia. European Journal of Neuroscience, 29, 1064-1070.
20. Holmes, J. M., & Clarke, M. P. (2006). Amblyopia. Lancet, 367, 1343-1351.
21. Jampolsky, A. (1955). Characteristics of suppression in strabismus. AMA Archives of Ophthalmology, 54, 683-696.
22. Joosse, M. V., Simonsz, H. J., van Minderhout, E. M., Mulder, P. G., & de Jong, P. T. (1999). Quantitative visual fields under binocular viewing conditions in primary and consecutive divergent strabismus. Graefe's Archive for Clinical and Experimental Ophthalmology, 237, 535-545.
23. Joosse, M. V., Simonsz, H. J., van Minderhout, H. M., de Jong, P. T., Noordzij, B., & Mulder, P. G. (1997). Quantitative perimetry under binocular viewing conditions in microstrabismus. Vision Research, 37, 2801-2812.
24. Lerner, Y., Hendler, T., Malach, R., Harel, M., Leiba, H., Stolovitch, C., et al. (2006). Selective fovea-related deprived activation in retinotopic and high-order visual cortex of human amblyopes. Neuroimage, 33, 169-179.
25. Lerner, Y., Pianka, P., Azmon, B., Leiba, H., Stolovitch, C., Loewenstein, A., et al. (2003). Area-specific amblyopic effects in human occipitotemporal object representations. Neuron, 40, 1023-1029.
26. Levi, D. M., Klein, S. A., & Yap, Y. L. (1987). Positional uncertainty in peripheral and amblyopic vision. Vision Research, 27, 581-597.
27. Li, X., Dumoulin, S. O., Mansouri, B., & Hess, R. F. (2007). The fidelity of the cortical retinotopic map in human amblyopia. European Journal of Neuroscience, 25, 1265-1277.
28. Lv, B., He, H., Li, X., Zhang, Z., Huang, W., Li, M., et al. (2008). Structural and functional deficits in human amblyopia. Neuroscience Letters, 437, 5-9.
29. Mansouri, B., Thompson, B., & Hess, R. F. (2008). Measurement of suprathreshold binocular interactions in amblyopia. Vision Research, 48, 2775-2784.
30. Pelli, D. G. (1997). The VideoToolbox software for visual psychophysics: Transforming numbers into movies. Spatial Vision, 10, 437-442.
31. Sengpiel, F., & Blakemore, C. (1994). Interocular control of neuronal responsiveness in cat visual cortex. Nature, 368, 847-850.
32. Sengpiel, F., & Blakemore, C. (1996). The neural basis of suppression and amblyopia in strabismus. Eye, 10, 250-258.
33. Sengpiel, F., Blakemore, C., Kind, P. C., & Harrad, R. (1994). Interocular suppression in the visual cortex of strabismic cats. Journal of Neuroscience, 14, 6855-6871.
34. Sengpiel, F., Jirmann, K. U., Vorobyov, V., & Eysel, U. T. (2006). Strabismic suppression is mediated by inhibitory interactions in the primary visual cortex. Cerebral Cortex, 16, 1750-1758.
35. Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. K. (2006). Negative functional MRI response correlates with decreases in neuronal activity inmonkey visual area V1. Nature Neuroscience, 9, 569-577.
36. Shmuel, A., Yacoub, E., Pfeuffer, J., Van deMoortele, P. F., Adriany, G., Hu, X., et al. (2002). Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron, 36, 1195-1210.
37. Simmers, A. J., Ledgeway, T., Hess, R. F., & McGraw, P. V. (2003). Deficits to global motion processing in human amblyopia. Vision Research, 43, 729-738.
38. Sireteanu, R. (2000). The binocular visual system in amblyopia. Strabismus, 8, 39-51.
39. Thompson, B., Farivar, R., Hansen, B. C., & Hess, R. F. (2008). A dichoptic projection system for visual psychophysics in fMRI scanners. Journal of Neuroscience Methods, 168, 71-75.
40. Tong, F., Meng, M., & Blake, R. (2006). Neural bases of binocular rivalry. Trends in Cognitive Sciences, 10, 502-511.
41. Travers, T. A. (1938). Suppression of vision in squint and its association with retinal correspondence and amblyopia. British Journal of Ophthalmology, 22, 577-604.
42. Tsuchiya, N., & Koch, C. (2005). Continuous flash suppression reduces negative afterimages. Nature Neuroscience, 8, 1096-1101.
43. Wiesel, T. N., & Hubel, D. H. (1965). Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. Journal of Neurophysiology, 28, 1029-1040.