Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor

Reproductive Sciences

Volumn 19, Issue 1, 2012, Pages 55-63

  Heng, Yujing J ^a,b   Quinzio, Megan K W Di ^a,b   Liong, Stella ^a,b   Permezel, Michael ^a,b   Rice, Gregory E ^a,c   Georgiou, Harry M ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MERCY HOSPITAL FOR WOMEN   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

cervicovaginal fluid; labor; matrix metalloproteinases; pregnancy; tissue inhibitors of matrix metalloproteinases

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANALYTIC METHOD; ARTICLE; BODY FLUID; CERVICOVAGINAL FLUID; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FEMALE; FETUS MEMBRANE; HOMEOSTASIS; HUMAN; LABOR; LABOR ONSET; MAJOR CLINICAL STUDY; MEMBRANE RUPTURE; MULTIPLEX SOLUTION ARRAY; OBSERVATIONAL STUDY; PARITY; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; TERM BIRTH; THIRD TRIMESTER PREGNANCY;

AMNIOTIC FLUID; CERVIX UTERI; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LABOR, OBSTETRIC; MATRIX METALLOPROTEINASE 7; PREGNANCY; RETROSPECTIVE STUDIES; TIME FACTORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; VAGINA;

EID: 84855454270     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111413299     Document Type: Article

References (46)

1. Weiss A, Goldman S, Shalev E. The matrix metalloproteinases (MMPS) in the decidua and fetal membranes. Front Biosci. 2007 ; 12: 649-659 (Pubitemid 46860207)
2. Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem. 1999 ; 274 (31). 21491-21494 (Pubitemid 129519680)
3. Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim Biophys Acta. 2010 ; 1803 (1). 55-71
4. Sennström MB, Brauner A, Byström B, Malmström A, Ekman G. Matrix metalloproteinase-8 correlates with the cervical ripening process in humans. Acta Obstet Gynecol Scand. 2003 ; 82 (10). 904-911 (Pubitemid 37159557)
5. Stygar D, Wang H, Vladic YS, et al. Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix. Biol Reprod. 2002 ; 67 (3). 889-894 (Pubitemid 34925209)
6. Watari M, Watari H, DiSanto ME, et al. Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells. Am J Pathol. 1999 ; 154 (6). 1755-1762 (Pubitemid 29262857)
7. Yoshida M, Sagawa N, Itoh H, et al. Nitric oxide increases matrix metalloproteinase-1 production in human uterine cervical fibroblast cells. Mol Hum Reprod. 2001 ; 7 (10). 979-985 (Pubitemid 32952180)
8. Ledingham MA, Denison FC, Riley SC, Norman JE. Matrix metalloproteinases-2 and -9 and their inhibitors are produced by the human uterine cervix but their secretion is not regulated by nitric oxide donors. Hum Reprod. 1999 ; 14 (8). 2089-2096 (Pubitemid 29381250)
9. Xu P, Alfaidy N, Challis JR. Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human placenta and fetal membranes in relation to preterm and term labor. J Clin Endocrinol Metab. 2002 ; 87 (3). 1353-1361 (Pubitemid 36121108)
10. Nishihara S, Someya A, Yonemoto H, et al. Evaluation of the expression and enzyme activity of matrix metalloproteinase-7 in fetal membranes during premature rupture of membranes at term in humans. Reprod Sci. 2008 ; 15 (2). 156-165 (Pubitemid 351903532)
11. Fortunato SJ, Menon R. Screening of novel matrix metalloproteinases (MMPs) in human fetal membranes. J Assist Reprod Genet. 2002 ; 19 (10). 483-486 (Pubitemid 35231181)
12. Moore RM, Mansour JM, Redline RW, Mercer BM, Moore JJ. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta. 2006 ; 27 (11-12). 1037-1051 (Pubitemid 44400517)
13. Roh CR, Oh WJ, Yoon BK, Lee JH. Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Mol Hum Reprod. 2000 ; 6 (1). 96-102
14. Maymon E, Romero R, Pacora P, et al. Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. Am J Obstet Gynecol. 2000 ; 183 (1). 94-99 (Pubitemid 30626034)
15. Fortunato SJ, Menon R, Lombardi SJ. Presence of four tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -3 and -4) in human fetal membranes. Am J Reprod Immunol. 1998 ; 40 (6). 395-400 (Pubitemid 29004945)
16. Becher N, Hein M, Danielsen CC, Uldbjerg N. Matrix metalloproteinases and their inhibitor in the cervical mucus plug at term of pregnancy. Am J Obstet Gynecol. 2004 ; 191 (4). 1232-1239 (Pubitemid 39421576)
17. Becher N, Hein M, Danielsen CC, Uldbjerg N. Matrix metalloproteinases in the cervical mucus plug in relation to gestational age, plug compartment, and preterm labor. Reprod Biol Endocrinol. 2010 ; 113: 8
18. Becher N, Hein M, Uldbjerg N, Danielsen CC. Balance between matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in the cervical mucus plug estimated by determination of free non-complexed TIMP. Reprod Biol Endocrinol. 2008 ; 45: 6
19. Choi SJ, Jung KL, Oh SY, Kim JH, Roh CR. Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition. Eur J Obstet Gynecol Reprod Biol. 2009 ; 142 (1). 43-47
20. Rahkonen L, Rutanen EM, Nuutila M, et al. Matrix metalloproteinase-8 in cervical fluid in early and mid pregnancy: relation to spontaneous preterm delivery. Prenat Diagn. 2010 ; 30 (11). 1079-1085
21. Di Quinzio MK, Oliva K, Holdsworth SJ, et al. Proteomic analysis and characterisation of human cervico-vaginal fluid proteins. Aust N Z J Obstet Gynaecol. 2007 ; 47 (1). 9-15 (Pubitemid 46152463)
22. Heng YJ, Di Quinzio MK, Permezel M, Rice GE, Georgiou HM. Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor. Am J Obstet Gynecol. 2008 ; 199 (6). e1 - e7
23. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991 ; 29 (2). 297-301
24. Kolkenbrock H, Orgel D, Hecker-Kia A, Noack W, Ulbrich N. The complex between a tissue inhibitor of metalloproteinases (TIMP-2) and 72-kDa progelatinase is a metalloproteinase inhibitor. Eur J Biochem. 1991 ; 198 (3). 775-781
25. Crabbe T, Willenbrock F, Eaton D, et al. Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases. Biochemistry.. 1992 ; 31 (36). 8500-8507
26. Miyazaki K, Funahashi K, Numata Y, et al. Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein. J Biol Chem. 1993 ; 268 (19). 14387-14393 (Pubitemid 23195566)
27. Maymon E, Romero R, Pacora P, et al. Matrilysin (matrix metalloproteinase 7) in parturition, premature rupture of membranes, and intrauterine infection. Am J Obstet Gynecol. 2000 ; 182 (6). 1545-1553 (Pubitemid 30437428)
28. Woessner JF. Matrix metalloproteinase inhibition. From The jurassic to the third millennium. Ann N Y Acad Sci. 1999 ; 878: 388-403
29. Murphy G, Cockett MI, Ward RV, Docherty AJ. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan: a quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP). Biochem J. 1991 ; 277 (pt 1). 277-279
30. Heng YJ, Di Quinzio MK, Permezel M, et al. Temporal proteomic analysis of human cervicovaginal fluid with impending term labor. J Proteome Res. 2010 ; 9 (3). 1344-1350
31. Goldman S, Weiss A, Eyali V, Shalev E. Differential activity of the gelatinases (matrix metalloproteinases 2 and 9) in the fetal membranes and decidua, associated with labour. Mol Hum Reprod. 2003 ; 9 (6). 367-373 (Pubitemid 36748842)
32. McLaren J, Taylor DJ, Bell SC. Increased concentration of pro-matrix metalloproteinase 9 in term fetal membranes overlying the cervix before labor: implications for membrane remodeling and rupture. Am J Obstet Gynecol. 2000 ; 182 (2). 409-416 (Pubitemid 30127356)
33. Agrez M, Gu X, Giles W. Matrix metalloproteinase 9 activity in urine of patients at risk for premature delivery. Am J Obstet Gynecol. 1999 ; 181 (2). 387-388 (Pubitemid 29409919)
34. Romero R, Chaiworapongsa T, Espinoza J, et al. Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. Am J Obstet Gynecol. 2002 ; 187 (5). 1125-1130 (Pubitemid 35397444)
35. Maymon E, Romero R, Pacora P, et al. A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection. J Perinat Med. 2001 ; 29 (4). 308-316 (Pubitemid 32802532)
36. Ota A, Yonemoto H, Someya A, et al. Changes in matrix metalloproteinase 2 activities in amnionchorions during premature rupture of membranes. J Soc Gynecol Investig. 2006 ; 13 (8). 592-597 (Pubitemid 44908992)
37. Riley SC, Leask R, Denison FC, et al. Secretion of tissue inhibitors of matrix metalloproteinases by human fetal membranes, decidua and placenta at parturition. J Endocrinol. 1999 ; 162 (3). 351-359 (Pubitemid 29447428)
38. Pentland AP, Shapiro SD, Welgus HG. Agonist-induced expression of tissue inhibitor of metalloproteinases and metalloproteinases by human macrophages is regulated by endogenous prostaglandin E2 synthesis. J Invest Dermatol. 1995 ; 104 (1). 52-57
39. Leppert PC. Cervical softening, effacement and dilatation: a complex biochemical cascade. J Matern Fetal Med. 1992 ; 1: 213-223
40. Winkler M, Oberpichler A, Tschesche H, et al. Collagenolysis in the lower uterine segment during parturition at term: correlations with stage of cervical dilatation and duration of labor. Am J Obstet Gynecol. 1999 ; 181 (1). 153-158 (Pubitemid 29343347)
41. Athayde N, Romero R, Gomez R, et al. Matrix metalloproteinases-9 in preterm and term human parturition. J Matern Fetal Med. 1999 ; 8 (5). 213-219 (Pubitemid 29383351)
42. Leitich H, Egarter C, Kaider A, et al. Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta-analysis. Am J Obstet Gynecol. 1999 ; 180 (5). 1169-1176 (Pubitemid 29259012)
43. Honest H, Bachamann LM, Gupta JK, Kleijnen J, Khan KS. Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review. BMJ. 2002 ; 325 (7359). 301
44. Sanchez-Ramos L, Delke I, Zamora J, Kaunitz AM. Fetal fibronectin as a short-term predictor of preterm birth in symptomatic patients: a meta-analysis. Obstet Gynecol. 2009 ; 114 (3). 631-640
45. Imai M, Tani A, Saito M, et al. Significance of fetal fibronectin and cytokine measurement in the cervicovaginal secretions of women at term in predicting term labor and post-term pregnancy. Eur J Obstet Gynaecol Reprod Biol. 2001 ; 97 (1). 53-58 (Pubitemid 32619118)
46. Timmons BC, Mahendroo M. Processes regulating cervical ripening differ from cervical dilation and postpartum repair: insights from gene expression studies. Reprod Sci. 2007 ; 14 (8 suppl). 53-62