Detection and identification of diterpenoid alkaloids, isoflavonoids and saponins in Qifu decoction and rat plasma by liquid chromatography-time-of-flight mass spectrometry

Biomedical Chromatography

Volumn 26, Issue 2, 2012, Pages 178-191

  Tan, Guangguo ^a,c   Jing, Jing ^a,c   Zhu, Zhenyu ^a   Lou, Ziyang ^a   Li, Wuhong ^a   Zhao, Liang ^b   Zhang, Guoqing ^b   Chai, Yifeng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c EASTERN HEPATOBILIARY SURGERY HOSPITAL   (China)

Author keywords

Diterpenoid alkaloids; Isoflavonoids; LC TOFMS; Qifu decoction; Saponins

Indexed keywords

ALKALOIDS; BODY FLUIDS; FLAVONOIDS; LIPIDS; MASS SPECTROMETRY; METABOLITES; RATS;

DITERPENOID ALKALOID; DITERPENOIDS; ISOFLAVONOIDS; LIQUID CHROMATOGRAPHY-TIME-OF-FLIGHT MASS SPECTROMETRIC; ORAL ADMINISTRATION; QIFU DECOCTION; RADIX ASTRAGALI; RAT PLASMA; SAPONIN; TIME-OF FLIGHT;

LIQUID CHROMATOGRAPHY;

ALKALOID; DITERPENOID; ION; ISOFLAVONOID; PLANT MEDICINAL PRODUCT; QIFU DECOCTION; SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CHEMICAL COMPOSITION; CHINESE HERB; DRUG ACTIVITY; DRUG DETERMINATION; DRUG STRUCTURE; FRAGMENTATION REACTION; LIQUID CHROMATOGRAPHY; NONHUMAN; RAT; TIME OF FLIGHT MASS SPECTROMETRY;

RATTUS;

EID: 84855448296     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1644     Document Type: Article

References (29)

1. Bessonova IA and Saidkhodzhaeva SA. Hetisane-type diterpenoid alkaloids. Chemistry of Natural Compounds 2000; 36(5): 419-477.
2. Diaz JG, Ruiza JG and Herz W. Norditerpene and diterpene alkaloids from Aconitum variegatum. Phytochemistry 2005; 66(7): 837-846.
3. Dong C, Li JL and Xu QY. Study on the effect of the immune function of Qifu decoction in old age mice. Chinese Journal of Hospital Pharmacy 2002; 22(10): 605-607.
4. Hao H, Cui N, Wang G, Xiang B, Liang Y, Xu X, Zhang H, Yang J, Zheng C, Wu L, Gong P and Wang W. Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy. Analytical Chemistry 2008; 80(21): 8187-8194.
5. Hu R, Zhao J, Qi LW, Li P, Jing SL and Li HJ. Structural characterization and identification of C(19)- and C(20)-diterpenoid alkaloids in roots of Aconitum carmichaeli by rapid-resolution liquid chromatography coupled with time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2009; 23(11): 1619-1635.
6. Huang X, Kong L, Li X, Chen X, Guo M and Zou H. Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines. Journal of Chromatography B 2004; 812(1-2): 71-84.
7. Ito K, Ohyama Y, Konishi Y, Tanaka S and Mizugaki M. Method for the simultaneous determination of Aconitum alkaloids and their hydrolysis products by gas chromatography-mass spectrometry in human serum. Planta Medica 1997; 63(1): 75-79.
8. Konno C, Shirasaka M and Hikino H. Structure of senbusine A, B and C, diterpenie alkaloids of aconitum carmichaeli roots from China. Journal of Natural Products 1982; 45(2): 128-133.
9. Lee MR, Chen CM, Hwang BH and Hsu LM. Analysis of saponins from black bean by electrospray ionization and fast atom bombardment tandem mass spectrometry. Journal of Mass Spectrometry 1999; 34(8): 804-812.
10. Lin LZ, He XG, Lindenmaier M, Nolan G, Yang J, Cleary M, Qiu SX and Cordell GA. Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. Journal of Chromatography A 2000; 876(1-2): 87-95.
11. Liu JH and Chen XF. Structure of guang fu base H. Journal of China Pharmaceutical University 1985; 16(3): 58-60.
12. Rashkes YV, Yunusov MS, Sirotenko EG and Vaisov ZM. Mass spectra of diterpene alkaloids with the hetisine skeleton. Chemistry of Natural Compounds 1987; 23(4): 452-461.
13. Song JZ, Mo SF, Yip YK, Qiao CF, Han QB and Xu HX. Development of microwave assisted extraction for the simultaneous determination of isoflavonoids and saponins in radix astragali by high performance liquid chromatography. Journal of Separation Science 2007; 30(6): 819-824.
14. Song JZ, Yiu HH, Qiao CF, Han QB and Xu HX. Chemical comparison and classification of Radix Astragali by determination of isoflavonoids and astragalosides. Journal of Pharmaceutical and Biomedical Analysis 2008; 47(2): 399-406.
15. Sultankhodzhaev MN, Yunusov MS and Yunusov SY. Alkaloids of Aconitum karakolicum. Chemistry of Natural Compounds 1973; 9(1): 129-130.
16. Tan G, Zhu Z, Zhang H, Zhao L, Liu Y, Dong X, Lou Z, Zhang G and Chai Y. Analysis of phenolic and triterpenoid compounds in licorice and rat plasma by high-performance liquid chromatography diode-array detection, time-of-flight mass spectrometry and quadrupole ion trap mass spectrometry. Rapid Communications in Mass Spectrometry 2010; 24(2): 209-218.
17. Vaisov ZM and Yunusov MS. 14-Acetylkarakoline - a new alkaloid from Delphinium confusum. Chemistry of Natural Compounds 1986; 22(6): 744-745.
18. Wang Y, Shi L, Song F, Liu Z and Liu S. Exploring the ester-exchange reactions of diester-diterpenoid alkaloids in the aconite decoction process by electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2003; 17(4): 279-284.
19. Wang Z, Wen J, Xing J and He Y. Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC. Journal of Pharmaceutical and Biomedical Analysis 2006; 40(4): 1031-1034.
20. Wu T, Annie Bligh SW, Gu LH, Wang ZT, Liu HP, Cheng XM, Branford-White CJ and Hu ZB. Simultaneous determination of six isoflavonoids in commercial Radix Astragali by HPLC-UV. Fitoterapia 2005; 76(2): 157-165.
21. Xiao HB, Krucker M, Albert K and Liang XM. Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. Journal of Chromatography A 2004; 1032(1-2): 117-124.
22. Xie Y, Jiang ZH, Zhou H, Xu HX and Liu L. Simultaneous determination of six Aconitum alkaloids in proprietary Chinese medicines by high-performance liquid chromatography. Journal of Chromatography A 2005; 1093(1-2): 195-203.
23. Xu Q, Ma X and Liang X. Determination of astragalosides in the roots of Astragalus spp. using liquid chromatography tandem atmospheric pressure chemical ionization mass spectrometry. Phytochemical Analysis 2007; 18(5): 419-427.
24. Yan G, Sun H, Sun W, Zhao L, Meng X and Wang X. Rapid and global detection and characterization of aconitum alkaloids in Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass spectrometry and automated data analysis. Journal of Pharmaceutical and Biomedical Analysis 2010; 53(3): 421-431.
25. Yuan MS. Analysis on pharmacology and clinical application of Qifu decoction. Chinese Medicine Modern Distance Education of China 2009; 7(12): 6.
26. Yue H, Pi Z, Song F, Liu Z, Cai Z and Liu S. Studies on the aconitine-type alkaloids in the roots of Aconitum carmichaeli Debx. by HPLC/ESIMS/MSn. Talanta 2009; 77(5): 1800-1807.
27. Zhang H, Li XD, Feng SL, Liu X, Hu FD and Li Y. Determination of astragaloside IV and isoflavoniods from Gansu Astragalus membranaceus. Journal of Lanzhou University 2006; 32: 64-66.
28. Zhou JL, Qi LW and Li P. Herbal medicine analysis by liquid chromatography/time-of-flight mass spectrometry. Journal of Chromatography A 2009; 1216(44): 7582-7594.
29. Zhou Y, Hirotani M, Rui H and Furuya T. Two triglycosidic triterpene astragalosides from hairy root cultures of Astragalus membranaceus. Phytochemistry 1995; 38(6): 1407-1410.