Modeling the onset and offset of dental pain relief by ibuprofen

Journal of Clinical Pharmacology

Volumn 52, Issue 1, 2012, Pages 89-101

  Li, Hanbin ^a   Mandema, Jaap ^a   Wada, Russell ^a   Jayawardena, Shyamalie ^b   Desjardins, Paul ^b   Doyle, Geraldine ^b   Kellstein, David ^b  

^a Quantitative Solutions Inc   (United States)

^b Pfizer Consumer Healthcare   (United States)

Author keywords

analgesia; dental pain; hazard model; Ibuprofen effervescent; nomogram; offset; onset; third molar extraction

Indexed keywords

IBUPROFEN; PLACEBO;

ADOLESCENT; ADULT; ANALGESIA; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG EFFICACY; FEMALE; HUMAN; LINEAR HAZARD MODEL; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NOMOGRAM; PAIN ASSESSMENT; PAIN RELIEF MODEL; PHARMACODYNAMICS; PROCESS MODEL; RANDOMIZED CONTROLLED TRIAL; REMEDICATION HAZARD MODEL; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TOOTH ANALGESIA;

ADOLESCENT; ADULT; ANALGESICS, NON-NARCOTIC; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IBUPROFEN; MALE; MODELS, BIOLOGICAL; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TOOTHACHE; YOUNG ADULT;

EID: 84855447305     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270010389470     Document Type: Article

References (29)

1. Moore N. Ibuprofen: a journey from prescription to over-the-counter use. J R Soc Med. 2007 ; 48: 2-6 (Pubitemid 351204439)
2. Moore N. Forty years of ibuprofen use. Int J Clin Pract Suppl. 2003 ; 135: 28-31 (Pubitemid 36458875)
3. Cooper SA, Schachtel BP, Goldman E, Gelb S, Cohn P. Ibuprofen and acetaminophen in the relief of acute pain: a randomized, double-blind, placebo-controlled study. J Clin Pharmacol. 1989 ; 29: 1026-1030 (Pubitemid 20038084)
4. Schachtel BP, Furey SA, Thoden WR. Nonprescription ibuprofen and acetaminophen in the treatment of tension-type headache. J Clin Pharmacol. 1996 ; 36: 1120-1125
5. Braun RP, Lockhart EA, Bruno P. Delayed onset muscle soreness (DOMS)-a new pain model to compare OTC analgesics [abstract]. Med Sci Sports Exerc. 1994 ; 14: 26
6. Schachtel BP, Fillingim JM, Thoden WR, Lane AC, Baybutt RI. Sore throat pain in the evaluation of mild analgesics. Clin Pharmacol Ther. 1988 ; 44: 704-711 (Pubitemid 19036624)
7. Schachtel BP, Thoden WR, Baybutt RI. Ibuprofen and acetaminophen in the relief of postpartum episiotomy pain. J Clin Pharmacol. 1989 ; 29: 550-553 (Pubitemid 19179686)
8. Cooper SA, Needle SE, Kruger GO. Comparative analgesic potency of aspirin and ibuprofen. J Oral Surg. 1977 ; 35: 898-903 (Pubitemid 8217919)
9. Laska EM, Sunshine A, Marrero I, Olson N, Siegel C, McCormick N. The correlation between blood levels of ibuprofen and clinical analgesic response. Clin Pharmacol Ther. 1986 ; 40: 1-7 (Pubitemid 16057974)
10. Schettler T, Paris S, Pellett M, Kidner S, Wilkinson D. Comparative pharmacokinetics of 2 fast-dissolving oral ibuprofen formulations and a regular-release ibuprofen tablet in healthy volunteers. Clin Drug Investig. 2001 ; 21 (6). 73-78 (Pubitemid 32128500)
11. Hersh EV, Levin LM, Cooper SA, et al. Ibuprofen liquigel for oral surgery pain. Clin Ther. 2000 ; 22: 1306-1318
12. Packman B, Packman E, Doyle G, et al. Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache. Headache. 2000 ; 40: 561-567 (Pubitemid 30497414)
13. Olson NZ, Otero AM, Marrero I, et al. Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. J Clin Pharmacol. 2001 ; 41: 1238-1247 (Pubitemid 32983223)
14. Black P, Max MB, Desjardins P, Norwood T, Ardia A, Pallotta T. A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, and tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clin Ther. 2002 ; 24: 1072-1089 (Pubitemid 34833231)
15. Desjardins P, Black P, Papageorge M, et al. Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen. Eur J Clin Pharmacol. 2002 ; 58: 387-394
16. Mehlisch DR, Ardia A, Pallotta T. A controlled comparative study of ibuprofen arginate versus conventional ibuprofen in the treatment of postoperative dental pain. J Clin Pharmacol. 2002 ; 42: 904-911 (Pubitemid 34803854)
17. Schleier P, Prochnau A, Schmidt-Westhausen AM, et al. Ibuprofen sodium dihydrate, an ibuprofen formulation with improved absorption characteristics, provides faster and greater pain relief than ibuprofen acid. Int J Clin Pharmacol Ther. 2007 ; 45: 89-97 (Pubitemid 46344140)
18. Sharma NK, Kindelan JD, Hutchinson D, Lancaster L. A study to compare ibuprofen effervescent granules with ibuprofen tablets in the treatment of acute dental pain. Prim Dent Care. 1994 ; 1: 5-8
19. Saano V, Paronen P, Peura P, Vidgren M. Relative pharmacokinetics of three oral 400 mg ibuprofen dosage forms in healthy volunteers. Int J Clin Pharmacol Ther Toxicol. 1991 ; 29: 381-385
20. Altomare E, Vendemiale G, Benvenuti C, Andreatta P. Bioavailability of a new effervescent tablet of ibuprofen in healthy volunteers. Eur J Clin Pharmacol. 1997 ; 52: 505-506 (Pubitemid 27395653)
21. Lemmens H, Stanski DR, Cooper S, Karpow S. Pharmacokinetic- Pharmacodynamics (PK/PD) of Ibuprofen in dental pain. J Clin Pharmacol. 1996 ; 36: 856
22. Bramlage P, Goldis A. Bioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers. BMC Pharmacol. 2008 ; 8: 18
23. Sorgel F, Fuhr U, Minic M, et al. Pharmacokinetics of ibuprofen sodium dihydrate and gastrointestinal tolerability of short-term treatment with a novel, rapidly absorbed formulation. Int J Clin Pharmacol Ther. 2005 ; 43: 140-149 (Pubitemid 40424747)
24. Beringer P, Aminimanizani A, Synold T, Scott C. Development of population pharmacokinetic models and optimal sampling times for ibuprofen tablet and suspension formulations in children with cystic fibrosis. Ther Drug Monit. 2002 ; 24: 315-321 (Pubitemid 34246560)
25. Albert KS, Gernaat CM. Pharmacokinetics of ibuprofen. Am J Med. 1984 ; 77: 40-46 (Pubitemid 14050196)
26. Troconiz IF, Armenteros S, Planelles MV, Benitez J, Calvo R, Dominguez R. Pharmacokinetic-Pharmacodynamic Modelling of the antipyretic effect of two oral formulations of ibuprofen. Clin Pharmacokinet. 2000 ; 38: 505-518 (Pubitemid 30394315)
27. Wagner JG, Albert KS, Szpunar GJ, Lockwood GF. Pharmacokinetics of ibuprofen in man IV: absorption and disposition. J Pharmacokinet Biopharm. 1984 ; 12: 381-399 (Pubitemid 15193433)
28. Mandema JW, Stanski DR. Population pharmacodynamic model for ketorolac analgesia. Clin Pharmacol Ther. 1996 ; 60: 619-635 (Pubitemid 27025909)
29. Rohatagi S, Kastrissios H, Sasahara K, et al. Pain relief model for a COX-2 inhibitor in patients with postoperative dental pain. Br J Clin Pharmacol. 2008 ; 66: 60-70 (Pubitemid 351822165)