Clinical significance of MUC1, MUC2 and CK17 expression patterns for diagnosis of pancreatobiliary arcinoma

Biotechnic and Histochemistry

Volumn 87, Issue 2, 2012, Pages 126-132

  Yang, H S ^a   Tamayo, R ^a   Almonte, M ^a   Horten, B ^a   Dasilva, M ^a   Gangi, M ^a   Vazquez, E ^a   Joseph, D ^a   Okamoto, P ^a   Scholl, T ^a  

^a Genzyme Genetics   (United States)

Author keywords

CK17; Immunohistochemistry; MUC1; MUC2; Pancreatobiliary carcinoma

Indexed keywords

CA 19-9 ANTIGEN; CYTOKERATIN 17; MUCIN 1; MUCIN 2; TUMOR MARKER;

ADENOCARCINOMA; ARTICLE; CHEMISTRY; HUMAN; IMMUNOHISTOCHEMISTRY; METASTASIS; PANCREAS TUMOR; PATHOLOGY; SENSITIVITY AND SPECIFICITY;

ADENOCARCINOMA; CA-19-9 ANTIGEN; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-17; MUCIN-1; MUCIN-2; PANCREATIC NEOPLASMS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84855443390     PISSN: 10520295     EISSN: 14737760     Source Type: Journal    
DOI: 10.3109/10520295.2011.570276     Document Type: Article

References (17)

1. Burdick MD, Harris A, Reid CJ, Iwamura T, Hollingsworth MA (1997) Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J. Biol. Chem. 272: 24198-24202. (Pubitemid 27418619)
2. Chu PG, Weiss LM (2002) Keratin expression in human tissues and neoplasms. Histopathology 40: 403-439. (Pubitemid 34535443)
3. Goldstein NS, Bassi D (2001) Cytokeratins 7, 17, and 20 reactivity in pancreatic and ampulla of vater adenocarcinomas. Percentage of positivity and distribution is affected by the cut-point threshold. Am. J. Clin. Pathol. 115: 695-702. (Pubitemid 33051536)
4. Higashi M, Yonezawa S, Ho JJ, Tanaka S, Irimura T, Kim YS, Sato E (1999) Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma. Hepatology 30: 1347-1355.
5. Ho JJ, Kim YS (1994) Serological pancreatic tumor markers and the MUC1 apomucin. Pancreas 9: 674-691. (Pubitemid 24317817)
6. Hollingsworth MA, Swanson BJ (2004) Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer 4: 45-60. (Pubitemid 38082153)
7. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer statistics, 2008. CA Cancer J. Clin. 58: 71-96. (Pubitemid 351521864)
8. Kurzen H, Esposito L, Langbein L, Hartschuh W (2001) Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma. Am. J. Dermatopathol. 23: 501-509. (Pubitemid 33086477)
9. Levi E, Klimstra DS, Andea A, Basturk O, Adsay NV (2004) MUC1 and MUC2 in pancreatic neoplasia. J. Clin. Pathol. 57: 456-462. (Pubitemid 38621788)
10. Masaki Y, Oka M, Ogura Y, Ueno T, Nishihara K, Tangoku A, Takahashi M, Yamamoto M, Irimura T (1999) Sialylated MUC1 mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma. Hepatogastroenterology 46: 2240-2245. (Pubitemid 29454075)
11. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31: 11-24. (Pubitemid 13215192)
12. Nakamura A, Horinouchi M, Goto M, Nagata K, Sakoda K, Takao S, Imai K, Kim YS, Sato, E, Yonezawa S (2002) New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy. J. Pathol. 197: 201-210. (Pubitemid 34567608)
13. Qu CF, Li Y, Song YJ, Rizvi SM, Raja C, Zhang D, Samra J, Smith R, Perkins AC, Apostolidis C, Allen BJ (2004) MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by (213)Bi-C595 radioimmunoconjugate. Br. J. Cancer 91: 2086-2093. (Pubitemid 40128776)
14. SafiF, Schlosser W, Falkenreck S, Beger HG (1998) Prognostic value of CA 19-9 serum course in pancreatic cancer. Hepatogastroenterology 45: 253-259. (Pubitemid 28067563)
15. Stathis A, Moore MJ (2010) Advanced pancreatic carcinoma: current treatment and future challenges. Nat. Rev. Clin. Oncol. 7: 163-172.
16. Yonezawa S, Sato E (1997) Expression of mucin antigens in human cancers and its relationship with malignancy potential. Pathol. Int. 47: 813-830. (Pubitemid 28087380)
17. Yonezawa S, Sueyoshi K, Nomoto M, Kitamura H, Nagata K, Arimura Y, Tanaka S, Hollingsworth MA, Siddiki B, Kim YS, Sato E (1997) MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum. Pathol. 28: 344-352. (Pubitemid 27106088)