A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage

Epilepsia

Volumn 53, Issue 1, 2012, Pages 134-146

  White, H Steve ^a   Alex, Anitha B ^a   Pollock, Amanda ^a   Hen, Naama ^b   Shekh Ahmad, Tawfeeq ^b   Wilcox, Karen S ^a   McDonough, John H ^c   Stables, James P ^d   Kaufmann, Dan ^b   Yagen, Boris ^b,e   Bialer, Meir ^b,e  

^a UNIVERSITY OF UTAH   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

New anticonvulsant drug; Pharmacokinetic pharmacodynamic correlation; Pilocarpine induced SE rat model; Soman induced SE rat model; Status epilepticus

Indexed keywords

ANTICONVULSIVE AGENT; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; ORGANOPHOSPHATE; PILOCARPINE; SEC BUTYL PROPYLACETAMIDE; SOMAN; UNCLASSIFIED DRUG; VALNOCTAMIDE; VALPROMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; ELECTRIC SHOCK; EPILEPTIC STATE; EXCITOTOXICITY; EXPERIMENTAL GUINEA PIG; HIPPOCAMPUS; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MAZE TEST; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMIDES; ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HIPPOCAMPUS; MALE; MICE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STATUS EPILEPTICUS; TIME FACTORS; TREATMENT OUTCOME; VALPROIC ACID;

EID: 84855441268     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03338.x     Document Type: Article

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