메뉴 건너뛰기




Volumn 122, Issue 1, 2012, Pages 16-19

The flip-flop HuR: Part of the problem or the solution in fighting cancer?

Author keywords

[No Author keywords available]

Indexed keywords

HUR PROTEIN; MESSENGER RNA;

EID: 84855431997     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61677     Document Type: Note
Times cited : (4)

References (23)
  • 1
    • 68449087605 scopus 로고    scopus 로고
    • Inflammation, microenvironment, and the immune system in cancer progression
    • Keibel A, Singh V, Sharma MC. Inflammation, microenvironment, and the immune system in cancer progression. Curr Pharm Des. 2009; 15(17):1949-1955.
    • (2009) Curr Pharm Des , vol.15 , Issue.17 , pp. 1949-1955
    • Keibel, A.1    Singh, V.2    Sharma, M.C.3
  • 2
    • 84855465218 scopus 로고    scopus 로고
    • Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
    • Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis DL. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest. 2012; 122(1):48-61.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 48-61
    • Yiakouvaki, A.1    Dimitriou, M.2    Karakasiliotis, I.3    Eftychi, C.4    Theocharis, S.5    Kontoyiannis, D.L.6
  • 3
    • 34547651351 scopus 로고    scopus 로고
    • Posttranscriptional orchestration of an anti-apoptotic program by HuR
    • Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle. 2007;6(11):1288-1292. (Pubitemid 47327958)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1288-1292
    • Abdelmohsen, K.1    Lal, A.2    Hyeon, H.K.3    Gorospe, M.4
  • 5
    • 2342573011 scopus 로고    scopus 로고
    • HuR in the mammalian genotoxic response: Post-transcriptional multitasking
    • Gorospe M. HuR in the mammalian genotoxic response: post-transcriptional multitasking. Cell Cycle. 2003;2(5):412-414.
    • (2003) Cell Cycle , vol.2 , Issue.5 , pp. 412-414
    • Gorospe, M.1
  • 7
    • 58149172080 scopus 로고    scopus 로고
    • Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    • Hostetter C, et al. Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Cancer Biol Ther. 2008;7(9):1496-1506.
    • (2008) Cancer Biol Ther , vol.7 , Issue.9 , pp. 1496-1506
    • Hostetter, C.1
  • 8
    • 53849124668 scopus 로고    scopus 로고
    • Diverse molecular functions of Hu proteins
    • Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci. 2008; 65(20):3168-3181.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.20 , pp. 3168-3181
    • Hinman, M.N.1    Lou, H.2
  • 11
    • 59849105830 scopus 로고    scopus 로고
    • Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR
    • Tong X, Pelling JC. Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR. Mol Carcinog. 2009;48(2):118-129.
    • (2009) Mol Carcinog , vol.48 , Issue.2 , pp. 118-129
    • Tong, X.1    Pelling, J.C.2
  • 12
    • 4544312897 scopus 로고    scopus 로고
    • Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity
    • Lopez de Silanes I, Fan J, Galban CJ, Spencer RG, Becker KG, Gorospe M. Global analysis of HuR regulated gene expression in colon cancer systems of reducing complexity. Gene Expr. 2004;12(1):49-59. (Pubitemid 39238136)
    • (2004) Gene Expression , vol.12 , Issue.1 , pp. 49-59
    • Lopez, D.S.I.1    Fan, J.2    Galban, C.J.3    Spencer, R.G.4    Becker, K.G.5    Gorospe, M.6
  • 13
    • 16744361844 scopus 로고    scopus 로고
    • Role of the RNA-binding protein HuR in colon carcinogenesis
    • Lopez de Silanes I, et al. Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene. 2003;22(46):7146-7154.
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7146-7154
    • Lopez De Silanes, I.1
  • 14
    • 27744520451 scopus 로고    scopus 로고
    • HuR: Posttranscriptional paths to malignancy
    • Lopez de Silanes I, Lal A, Gorospe M. HuR: posttranscriptional paths to malignancy. RNA Biol. 2005;2(1):11-13.
    • (2005) RNA Biol , vol.2 , Issue.1 , pp. 11-13
    • Lopez De Silanes, I.1    Lal, A.2    Gorospe, M.3
  • 15
    • 77951030151 scopus 로고    scopus 로고
    • HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells
    • Rhee WJ, Ni CW, Zheng Z, Chang K, Jo H, Bao G. HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010;107(15):6858-6863.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.15 , pp. 6858-6863
    • Rhee, W.J.1    Ni, C.W.2    Zheng, Z.3    Chang, K.4    Jo, H.5    Bao, G.6
  • 16
    • 58549107584 scopus 로고    scopus 로고
    • Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: High expression of HuR predicts poor survival
    • Yoo PS, et al. Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival. Ann Surg Oncol. 2009;16(1):200-207.
    • (2009) Ann Surg Oncol , vol.16 , Issue.1 , pp. 200-207
    • Yoo, P.S.1
  • 18
    • 9144266290 scopus 로고    scopus 로고
    • Overexpression of the Embryonic-Lethal Abnormal Vision-like Protein HuR in Ovarian Carcinoma Is a Prognostic Factor and Is Associated with Increased Cyclooxygenase 2 Expression
    • DOI 10.1158/0008-5472.CAN-03-1987
    • Denkert C, et al. Overexpression of the embryoniclethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res. 2004;64(1):189-195. (Pubitemid 38114097)
    • (2004) Cancer Research , vol.64 , Issue.1 , pp. 189-195
    • Denkert, C.1    Weichert, W.2    Pest, S.3    Koch, I.4    Licht, D.5    Kobel, M.6    Reles, A.7    Sehouli, J.8    Dietel, M.9    Hauptmann, S.10
  • 19
    • 77955750366 scopus 로고    scopus 로고
    • Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
    • Gubin MM, et al. Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis. Cell Cycle. 2010;9(16):3337-3346.
    • (2010) Cell Cycle , vol.9 , Issue.16 , pp. 3337-3346
    • Gubin, M.M.1
  • 20
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    • Costantino CL, et al. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res. 2009;69(11):4567-4572.
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4567-4572
    • Costantino, C.L.1
  • 21
    • 43049181690 scopus 로고    scopus 로고
    • Immune cells in colorectal cancer: Prognostic relevance and therapeutic strategies
    • DOI 10.1586/14737140.8.4.561
    • Atreya I, Neurath MF. Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies. Expert Rev Anticancer Ther. 2008;8(4):561-572. (Pubitemid 351818351)
    • (2008) Expert Review of Anticancer Therapy , vol.8 , Issue.4 , pp. 561-572
    • Atreya, I.1    Neurath, M.F.2
  • 22
    • 77957171606 scopus 로고    scopus 로고
    • Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer
    • Lim SJ, Lee SH, Joo SH, Song JY, Choi SI. Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer. Cancer Res Treat. 2009;41(2):87-92.
    • (2009) Cancer Res Treat , vol.41 , Issue.2 , pp. 87-92
    • Lim, S.J.1    Lee, S.H.2    Joo, S.H.3    Song, J.Y.4    Choi, S.I.5
  • 23
    • 65349120262 scopus 로고    scopus 로고
    • The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis
    • Young LE, Sanduja S, Bemis-Standoli K, Pena EA, Price RL, Dixon DA. The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology. 2009;136(5):1669-1679.
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1669-1679
    • Young, L.E.1    Sanduja, S.2    Bemis-Standoli, K.3    Pena, E.A.4    Price, R.L.5    Dixon, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.